Philip J. Breen

High Impact

Researcher

University of Arkansas for Medical Sciences

faculty

20 h-index 49 pubs 1,871 cited

Research Areas

Phytochemicals and Antioxidant Activities Cancer Treatment and Pharmacology Pharmacological Effects and Toxicity Studies Radiology practices and education Health and Medical Research Impacts Neuroscience and Neuropharmacology Research

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OverviewAI-generated summary

Philip J. Breen's research focuses on the development and analysis of compounds with potential therapeutic applications, particularly in the areas of cancer and radiation mitigation. His work includes investigating the mechanisms by which tocotrienols, a form of vitamin E, can protect organ systems from radiation damage through antioxidant and signaling pathways. Breen has also explored plant-derived compounds for their antileukemic properties, examining interactions between plants to identify potent therapeutic agents.

Further research extends into the pharmacokinetic study of specific drugs, such as morphine-6-O-sulfate, analyzing its distribution in biological systems like rat plasma and brain. His group is involved in the development of novel analogs, such as tocoflexol, aiming to enhance radiomitigation effects. Breen leads a research group at the University of Arkansas for Medical Sciences and has a publication record that has led to his designation as a highly cited researcher. His scholarly output includes 49 publications with 1,871 citations and an h-index of 20.

Metrics

  • h-index: 20
  • Publications: 49
  • Citations: 1,871

Selected Publications

  • Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects (2023) DOI
  • 466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator (2023) DOI
  • Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds (2022) DOI
  • A pharmacokinetic study of <scp>morphine‐6‐<i>O</i></scp>‐sulfate in rat plasma and brain (2021) DOI

Grants & Funding

Collaborators

Researchers in the database who share publications

Darin E. Jones University of Arkansas for Medical Sciences 4 shared publications David E. Mery University of Arkansas for Medical Sciences 2 shared publications Edward J. Selvik University of Arkansas for Medical Sciences 2 shared publications Nükhet Aykin‐Burns University of Arkansas for Medical Sciences 2 shared publications Shivangi Shrimali National Center for Toxicological Research 2 shared publications Narsimha Reddy Penthala University of Arkansas for Medical Sciences 1 shared publication Peter A. Crooks University of Arkansas for Medical Sciences 1 shared publication Jai Shankar K. Yadlapalli University of Arkansas for Medical Sciences 1 shared publication

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