Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-06
J
Jin‐Ran Chen
Federal Grant PI
High Impact
Associate Professor
Also affiliated: United States Department of Agriculture (2011); University of Arkansas Medical Center (2023); Central Arkansas Veterans Healthcare System (2002–2005); Arkansas Children's Nutrition Center (2006–2026); California State University, Long Beach (2012); Louisiana State University Health Sciences Center New Orleans (2018); Texas A&M University (2018)
31 h-index
102 pubs
3,447 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Jin-Ran Chen's research group at the University of Arkansas for Medical Sciences investigates molecular mechanisms underlying bone metabolism and diseases, as well as cancer progression. Their work has explored how various factors, including sex steroids, glucocorticoids, and dietary components, influence bone cell activity and density. For example, publications detail the kinase-mediated regulation of transcription factors in bone protection and how dietary phenolic acids promote bone growth via specific signaling pathways. The group has also studied the impact of obesity on bone density, linking it to the activation of certain receptors and suppression of key signaling pathways in rapidly growing male rats. Furthermore, Chen's group examines the role of oxidative stress and ethanol in regulating mesenchymal stromal cell lineage commitment through Wnt/β-catenin signaling. Their research extends to cancer, with federal funding from the NIH/National Cancer Institute supporting their investigation into novel NEK2 signaling pathways in myeloma progression. Chen is recognized as a highly cited researcher, with a publication record of 99 papers and over 3,300 citations.
Metrics
- h-index: 31
- Publications: 102
- Citations: 3,447
Positions
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Associate Professor publications 2002–2026University of Arkansas for Medical Sciences Institution web page
Selected Publications
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Bone mineral density, bone remodeling biomarkers, and hemostatic correlates in hemophilia and von Willebrand disease (2026)
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Soy Isoflavones Prevent Bone Quality Loss Induced by High‐Fat Diet in Rats Through Epigenetic Modifications (2025)
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Sex dependent effects of GPR109A gene deletion in myeloid cells on bone development in mice (2025)
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Soy Isoflavones Prevent Loss of Bone Quality Associated With High Fat Diet in Rats Through Ameliorating Epigenetic Modifications in Bone (2025)
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Acetate derived from metabolism of ethanol affects gene expression in bone and contributes to delays in chondrogenic differentiation (2025)
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Sex-dependent effect of GPR109A gene deletion in myeloid cells on bone development in mice (2025)
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Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption (2025)
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Cystatin M/E ameliorates bone resorption through increasing osteoclastic cell estrogen influx (2024)
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Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice (2024)
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High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma (2023)
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A gene signature can predict risk of MGUS progressing to multiple myeloma (2023)
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Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model (2023)
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A Gene Signature Can Predict Risk of MGUS Progressing to Multiple Myeloma (2023)
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A longitudinal observational study of skeletal development between ages 3 mo and 6 y in children fed human milk, milk formula, or soy formula (2023)
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Exploring GPR109A Receptor Interaction with Hippuric Acid Using MD Simulations and CD Spectroscopy (2022)
Federal Grants 1 $330,316 total
NIH
Contact PI
Jun 2020 - May 2026
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Dietary Soy Proteins During Early Life Program Bone Formation UAMS ACHRI Flow Through
- CUMG UAMS College of Medicine
Collaboration Network
Top Collaborators
Oxana P. Lazarenko
Arkansas Children's Nutrition Center
47 shared publications
In database
- Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
- Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats
- Ethanol Impairs Estrogen Receptor Signaling Resulting in Accelerated Activation of Senescence Pathways, Whereas Estradiol Attenuates the Effects of Ethanol in Osteoblasts
- Feeding Blueberry Diets in Early Life Prevent Senescence of Osteoblasts and Bone Loss in Ovariectomized Adult Female Rats
- Inhibition of fetal bone development through epigenetic down‐regulation of HoxA10 in obese rats fed high‐fat diet
Showing 5 of 47 shared publications
Michael L. Blackburn
Arkansas Children's Nutrition Center
34 shared publications
In database
- Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
- Maternal Obesity Promotes a Proinflammatory Signature in Rat Uterus and Blastocyst
- Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats
- Ethanol Impairs Estrogen Receptor Signaling Resulting in Accelerated Activation of Senescence Pathways, Whereas Estradiol Attenuates the Effects of Ethanol in Osteoblasts
- Feeding Blueberry Diets in Early Life Prevent Senescence of Osteoblasts and Bone Loss in Ovariectomized Adult Female Rats
Showing 5 of 34 shared publications
Martin J. J. Ronis
Louisiana State University Health Sciences Center New Orleans (US)
31 shared publications
- Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
- Maternal Obesity Promotes a Proinflammatory Signature in Rat Uterus and Blastocyst
- Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats
- Ethanol Impairs Estrogen Receptor Signaling Resulting in Accelerated Activation of Senescence Pathways, Whereas Estradiol Attenuates the Effects of Ethanol in Osteoblasts
- Feeding Blueberry Diets in Early Life Prevent Senescence of Osteoblasts and Bone Loss in Ovariectomized Adult Female Rats
Showing 5 of 31 shared publications
Thomas M. Badger
Arkansas Children's Nutrition Center
29 shared publications
In database
- Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
- Maternal Obesity Promotes a Proinflammatory Signature in Rat Uterus and Blastocyst
- Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats
- Ethanol Impairs Estrogen Receptor Signaling Resulting in Accelerated Activation of Senescence Pathways, Whereas Estradiol Attenuates the Effects of Ethanol in Osteoblasts
- Feeding Blueberry Diets in Early Life Prevent Senescence of Osteoblasts and Bone Loss in Ovariectomized Adult Female Rats
Showing 5 of 29 shared publications
Kartik Shankar
Arkansas Children's Nutrition Center (US)
21 shared publications
- Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
- Maternal Obesity Promotes a Proinflammatory Signature in Rat Uterus and Blastocyst
- Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats
- Feeding Blueberry Diets in Early Life Prevent Senescence of Osteoblasts and Bone Loss in Ovariectomized Adult Female Rats
- Estradiol Protects against Ethanol-Induced Bone Loss by Inhibiting Up-Regulation of Receptor Activator of Nuclear Factor-κB Ligand in Osteoblasts
Showing 5 of 21 shared publications
Dongzheng Gai
Winthrop Rockefeller Foundation
8 shared publications
In database
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma
- A gene signature can predict risk of MGUS progressing to multiple myeloma
- Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model
- Ezh2 mediates epigenetic regulation of osteoclastogenesis and bone remodeling in mice
Showing 5 of 8 shared publications
Teresita Bellido
Central Arkansas Veterans Healthcare System
7 shared publications
In database
- Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids
- Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids
- Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids
- Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids
- Nongenotropic, Anti-Apoptotic Signaling of 1α,25(OH)2-Vitamin D3 and Analogs through the Ligand Binding Domain of the Vitamin D Receptor in Osteoblasts and Osteocytes
Showing 5 of 7 shared publications
Umesh D. Wankhade
Arkansas Children's Nutrition Center
7 shared publications
In database
- Sex-Specific Changes in Gut Microbiome Composition following Blueberry Consumption in C57BL/6J Mice
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- 3‐(3‐Hydroxyphenyl)‐Propionic Acid (PPA) Suppresses Osteoblastic Cell Senescence to Promote Bone Accretion in Mice
- Nox4 Expression Is Not Required for OVX ‐Induced Osteoblast Senescence and Bone Loss in Mice
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
Showing 5 of 7 shared publications
Fenghuang Zhan
Winthrop Rockefeller Foundation
7 shared publications
In database
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- A gene signature can predict risk of MGUS progressing to multiple myeloma
- Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice
- Ezh2 mediates epigenetic regulation of osteoclastogenesis and bone remodeling in mice
Showing 5 of 7 shared publications
Jennifer F. Chen
Arkansas Children's Nutrition Center
7 shared publications
In database
- Nox4 expression in osteo-progenitors controls bone development in mice during early life
- Nox4 expression in osteo-progenitors controls bone development in mice during early life
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice
- Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption
Showing 5 of 7 shared publications
Perry C. Caviness
Arkansas Children's Nutrition Center
7 shared publications
In database
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
- Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice
- Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption
- Soy Isoflavones Prevent Bone Quality Loss Induced by High‐Fat Diet in Rats Through Epigenetic Modifications
Showing 5 of 7 shared publications
Kelly E. Mercer
Arkansas Children's Nutrition Center
6 shared publications
In database
- Effects of Nutrition and Alcohol Consumption on Bone Loss
- Vitamin D Supplementation Protects against Bone Loss Associated with Chronic Alcohol Administration in Female Mice
- p47 -Nox2-dependent ROS Signaling Inhibits Early Bone Development in Mice but Protects against Skeletal Aging
- Loss of Functional NADPH Oxidase 2 Protects Against Alcohol‐Induced Bone Resorption in Female p47phox −/− Mice
- Partial Protection by Dietary Antioxidants Against Ethanol‐Induced Osteopenia and Changes in Bone Morphology in Female Mice
Showing 5 of 6 shared publications
Haijun Zhao
Arkansas Children's Nutrition Center (US)
6 shared publications
- Maternal obesity impairs skeletal development in adult offspring
- Hippuric acid and 3‐(3‐hydroxyphenyl) propionic acid inhibit murine osteoclastogenesis through RANKL‐RANK independent pathway
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- Maternal regulation of SATB2 in osteo‐progeniters impairs skeletal development in offspring
- Nox4 Expression Is Not Required for OVX ‐Induced Osteoblast Senescence and Bone Loss in Mice
Showing 5 of 6 shared publications
Xianli Wu
Arkansas Children's Nutrition Center (US)
5 shared publications
- Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
- Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats
- Phenolic Acids Are in Vivo Atheroprotective Compounds Appearing in the Serum of Rats after Blueberry Consumption
- Differential Effects of Short Term Feeding of a Soy Protein Isolate Diet and Estrogen Treatment on Bone in the Pre-Pubertal Rat
- Lowbush blueberries inhibit scavenger receptors CD36 and SR-A expression and attenuate foam cell formation in ApoE-deficient mice
Fumou Sun
Winthrop Rockefeller Foundation
5 shared publications
In database
- High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma
- A gene signature can predict risk of MGUS progressing to multiple myeloma
- Cystatin M/E ameliorates bone resorption through increasing osteoclastic cell estrogen influx
- Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption
- A Gene Signature Can Predict Risk of MGUS Progressing to Multiple Myeloma
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