Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-20
J
Jinhu Xiong
Federal Grant PI
High Impact
Associate Professor
Also affiliated: University of Arkansas Medical Center (2025); Arkansas Cardiology (2023); Central Arkansas Veterans Healthcare System (2011–2018); Institute for Musculoskeletal Health (2025); Bone Health and Osteoporosis Foundation (2016)
Faculty Researcher
Orthopaedics Surgery, College of Medicine
22 h-index
42 pubs
4,384 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Jinhu Xiong's research focuses on bone biology, specifically investigating the mechanisms of bone loss associated with aging and disease, and exploring potential therapeutic interventions grounded in mechanobiology. He has received NIH funding for a project examining the role of Piezo1 in bone homeostasis and mechanotransduction. His recent publications explore the function of Piezo1 in mature osteocytes and its impact on mitochondrial activity, as well as its potential to counteract age-related bone loss.
Xiong's work also delves into identifying and characterizing mesenchymal cell types involved in bone formation and maintenance. He has investigated strategies to mitigate bone loss induced by aging and chemotherapy in mice, utilizing mechanobiology-based treatments. His scholarship metrics include an h-index of 22, with over 4,300 citations across 40 publications. He collaborates with researchers at the University of Arkansas for Medical Sciences, including Melda Onal, Charles A. O’Brien, and Maria Almeida.
Metrics
- h-index: 22
- Publications: 42
- Citations: 4,384
Selected Publications
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Protocol for the enrichment of endosteal and periosteal mesenchymal cells from murine bone for single-cell transcriptome analysis (2026)
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A transcriptomic-driven segmentation and cell simulation framework for high-resolution spatial transcriptomics and cell-cell communication (2026)
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Dissecting primary versus secondary effects of osteogenesis imperfecta on abnormal lung development and function (2026)
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The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone (2025)
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Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength (2025)
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Different effects of moderate tibial loading and Yoda1 on breast cancer-induced osteolysis in aged mice (2025)
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Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness (2025)
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Piezo1 expression in mature osteocytes is dispensable for the skeletal response to mechanical loading (2024)
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Mitigating aging and doxorubicin induced bone loss in mature mice via mechanobiology based treatments (2024)
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Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone (2024)
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A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone (2023)
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Piezo1 opposes age‐associated cortical bone loss (2023)
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Piezo1 stimulates mitochondrial function via <scp>cAMP</scp> signaling (2022)
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Deletion of a putative promoter-proximal Tnfsf11 regulatory region in mice does not alter bone mass or Tnfsf11 expression in vivo (2021)
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New Advances in Osteocyte Mechanotransduction (2021)
Federal Grants 1 $324,368 total
NIH
Contact PI
Aug 2020 - Jun 2026
The role of Piezo1 in bone homeostasis and mechanotransduction
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Osteocyte Control of Bone Remodeling NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases Co-Investigator
- Center for Musculoskeletal Disease Research (CMDR) NIH/Nat. Inst. of General Medical Sciences Co-Investigator
- The role of Piezo 1 in bone homeostasis and mechanotransduction NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases Principal Investigator
Collaboration Network
Top Collaborators
Melda Onal
University of Arkansas for Medical Sciences
5 shared publications
In database
- Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone
- Deletion of a putative promoter-proximal Tnfsf11 regulatory region in mice does not alter bone mass or Tnfsf11 expression in vivo
- Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness
- The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone
- A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone
Xuehua Li
University of Arkansas for Medical Sciences
4 shared publications
In database
- New Advances in Osteocyte Mechanotransduction
- Piezo1 stimulates mitochondrial function via <scp>cAMP</scp> signaling
- Mitigating aging and doxorubicin induced bone loss in mature mice via mechanobiology based treatments
- Different effects of moderate tibial loading and Yoda1 on breast cancer-induced osteolysis in aged mice
Charles A. O’Brien
University of Arkansas for Medical Sciences
4 shared publications
In database
- Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone
- Deletion of a putative promoter-proximal Tnfsf11 regulatory region in mice does not alter bone mass or Tnfsf11 expression in vivo
- The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone
- A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone
Intawat Nookaew
University of Arkansas for Medical Sciences
4 shared publications
In database
- Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone
- Piezo1 stimulates mitochondrial function via <scp>cAMP</scp> signaling
- The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone
- A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone
Ha‐Neui Kim
University of Arkansas for Medical Sciences
4 shared publications
In database
- Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone
- Piezo1 stimulates mitochondrial function via <scp>cAMP</scp> signaling
- The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone
- A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone
Maria Almeida
University of Arkansas for Medical Sciences
4 shared publications
In database
- Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone
- Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness
- The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone
- A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone
Qiang Fu
University of Arkansas for Medical Sciences
3 shared publications
In database
- Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone
- Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness
- A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone
Jacob Kordsmeier
University of Arkansas for Medical Sciences
2 shared publications
In database
- New Advances in Osteocyte Mechanotransduction
- Piezo1 stimulates mitochondrial function via <scp>cAMP</scp> signaling
Jeff D. Thostenson
University of Arkansas for Medical Sciences
2 shared publications
In database
- Deletion of a putative promoter-proximal Tnfsf11 regulatory region in mice does not alter bone mass or Tnfsf11 expression in vivo
- Dissecting primary versus secondary effects of osteogenesis imperfecta on abnormal lung development and function
Xuehua Li
University of Arkansas for Medical Sciences (US)
2 shared publications
- Piezo1 opposes age‐associated cortical bone loss
- Piezo1 expression in mature osteocytes is dispensable for the skeletal response to mechanical loading
Connie Zhang
University of Arkansas for Medical Sciences (US)
2 shared publications
- Piezo1 opposes age‐associated cortical bone loss
- Piezo1 expression in mature osteocytes is dispensable for the skeletal response to mechanical loading
Cecile Bustamante-Gomez
University of Arkansas for Medical Sciences
2 shared publications
In database
- Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone
- A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone
Visanu Wanchai
University of Arkansas for Medical Sciences
2 shared publications
In database
- Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone
- A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone
Murtaza Wasi
University of Delaware (US)
2 shared publications
- Mitigating aging and doxorubicin induced bone loss in mature mice via mechanobiology based treatments
- Different effects of moderate tibial loading and Yoda1 on breast cancer-induced osteolysis in aged mice
Tiankuo Chu
University of Delaware (US)
2 shared publications
- Mitigating aging and doxorubicin induced bone loss in mature mice via mechanobiology based treatments
- Different effects of moderate tibial loading and Yoda1 on breast cancer-induced osteolysis in aged mice
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