Match tier
Confirmed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-09
T
Tyrone A. Washington
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Federal Grant PI
High Impact
Associate Professor
Also affiliated: National Institutes of Health (2007); University of South Carolina (2001–2014); Iowa State University (2007); Southern Illinois University Edwardsville (2016); Texas A&M University (2015); McMaster University (2023)
27 h-index
167 pubs
2,190 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Tyrone A. Washington's research focuses on the molecular mechanisms underlying skeletal muscle wasting and regeneration, with a particular emphasis on conditions such as cancer cachexia and diet-induced obesity. His work investigates the role of mitochondrial function, protein imbalance, and microRNA regulation in the development and progression of muscle atrophy. He has explored how factors like PGC-1α and Western diet impact mitochondrial quality control and how physical activity can partially restore these processes in mice. His studies have also examined alterations in microRNAs that are important for maintaining muscle size during cancer cachexia.
Washington has also investigated strategies for muscle recovery following injury. His NIH-funded project, "Regenerative and Rehabilitation Strategies to Reduce Inflammation Following Volumetric Muscle Loss Injury," awarded $434,793, examines methods to improve recovery from volumetric muscle loss injuries using decellularized skeletal muscle and minced muscle autografts in a rat model. His research group at the University of Arkansas at Fayetteville includes collaborators such as Eleanor R. Schrems, Franciel Morena da Silva, Ana Regina Cabrera, and Nicholas P. Greene, with whom he has co-authored numerous publications.
With an h-index of 27 and over 171 publications, Washington is recognized as a highly cited researcher. His work contributes to understanding disease models of muscle atrophy, the impact of diet on metabolism and muscle health, and potential therapeutic interventions for musculoskeletal disorders.
Metrics
- h-index: 27
- Publications: 167
- Citations: 2,190
Positions
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Associate Professor 2017–presentUniversity of Arkansas Department of Health, Human Performance and Recreation ORCID
Selected Publications
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Exercise training prior to and during cancer in mice preserves muscle mass, reduces tumour weight and suppresses molecular mediators of cachexia (2026)
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TRAIL: A potential new biomarker for muscle health in anorexia nervosa (2026)
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American College of Sports Medicine Position Stand. Resistance Training Prescription for Muscle Function, Hypertrophy, and Physical Performance in Healthy Adults: An Overview of Reviews (2026)
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Skeletal muscle methylome-transcriptome disruptions during the onset and progression of colorectal cancer-induced cachexia (2025)
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Transcriptomic analysis demonstrates moderators of muscle quality are altered in age-related sarcopenic obesity (2025)
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Unravelling the diversity observed in cancer cachexia (2025)
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Aerobic Exercise Training Does Not Attenuate Fibrosis In Autologous Repaired Vml-injured Skeletal Muscle (2025)
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Skeletal Muscle Damage and Inflammation (2025)
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Promoting mitochondrial fusion is protective against cancer-induced muscle detriments in males and females (2025)
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Global mitophagy inhibition via BNIP3 ablation is not sufficient to alleviate skeletal muscle impairments in male and female tumor-bearing mice (2025)
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Myocellular adaptations to short‐term weighted wheel‐running exercise are largely conserved during C26‐tumour induction in male and female mice (2025)
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Transcriptional analysis of cancer cachexia: conserved and unique features across preclinical models and biological sex (2024)
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Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice (2024)
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Supplemental table 6 (2023)
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Supplemental table 1 (2023)
Federal Grants 1 $434,793 total
NIH
Contact PI
Aug 2024 - Jul 2027
Collaboration Network
Top Collaborators
Nicholas P. Greene
University of Arkansas at Fayetteville
95 shared publications
In database
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
- Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice
- Diet‐induced obesity alters anabolic signalling in mice at the onset of skeletal muscle regeneration
- Cancer cachexia-induced muscle atrophy: evidence for alterations in microRNAs important for muscle size
Showing 5 of 95 shared publications
Jacob L. Brown
University of Arkansas at Fayetteville (US)
60 shared publications
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
- Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice
- Diet‐induced obesity alters anabolic signalling in mice at the onset of skeletal muscle regeneration
- Cancer cachexia-induced muscle atrophy: evidence for alterations in microRNAs important for muscle size
Showing 5 of 60 shared publications
Megan E. Rosa‐Caldwell
University of Arkansas at Fayetteville
60 shared publications
In database
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
- Cancer cachexia-induced muscle atrophy: evidence for alterations in microRNAs important for muscle size
- Hepatic alterations during the development and progression of cancer cachexia
- Transcriptomic analysis of the development of skeletal muscle atrophy in cancer-cachexia in tumor-bearing mice
Showing 5 of 60 shared publications
Richard Perry
Colorado State University (US)
59 shared publications
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
- Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice
- Diet‐induced obesity alters anabolic signalling in mice at the onset of skeletal muscle regeneration
- Cancer cachexia-induced muscle atrophy: evidence for alterations in microRNAs important for muscle size
Showing 5 of 59 shared publications
Lemuel A. Brown
University of Michigan
56 shared publications
In database
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
- Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice
- Codelivery of Infusion Decellularized Skeletal Muscle with Minced Muscle Autografts Improved Recovery from Volumetric Muscle Loss Injury in a Rat Model
- Diet‐induced obesity alters anabolic signalling in mice at the onset of skeletal muscle regeneration
Showing 5 of 56 shared publications
David E. Lee
University of Arkansas at Fayetteville (US)
49 shared publications
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
- Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice
- Cancer cachexia-induced muscle atrophy: evidence for alterations in microRNAs important for muscle size
- microRNA‐16 Is Downregulated During Insulin Resistance and Controls Skeletal Muscle Protein Accretion
Showing 5 of 49 shared publications
Wesley S. Haynie
University of Arkansas at Fayetteville
35 shared publications
In database
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
- Hepatic alterations during the development and progression of cancer cachexia
- Transcriptomic analysis of the development of skeletal muscle atrophy in cancer-cachexia in tumor-bearing mice
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
Showing 5 of 35 shared publications
Eleanor R. Schrems
University of Arkansas at Fayetteville
28 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
Showing 5 of 28 shared publications
Michael P. Wiggs
Baylor University (US)
25 shared publications
- Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
- Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
- Cancer cachexia-induced muscle atrophy: evidence for alterations in microRNAs important for muscle size
- microRNA‐16 Is Downregulated During Insulin Resistance and Controls Skeletal Muscle Protein Accretion
- Hepatic alterations during the development and progression of cancer cachexia
Showing 5 of 25 shared publications
Seongkyun Lim
University of Arkansas at Fayetteville
25 shared publications
In database
- Development and progression of cancer cachexia: Perspectives from bench to bedside
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
Showing 5 of 25 shared publications
Ana Regina Cabrera
University of Arkansas at Fayetteville
25 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
Showing 5 of 25 shared publications
Francielly Morena da Silva
University of Arkansas at Fayetteville
23 shared publications
In database
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
Showing 5 of 23 shared publications
Kevin A. Murach
University of Arkansas at Fayetteville
18 shared publications
In database
- Exercise Counteracts the Deleterious Effects of Cancer Cachexia
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- Transcriptional analysis of cancer cachexia: conserved and unique features across preclinical models and biological sex
- Biological sex divergence in transcriptomic profiles during the onset of hindlimb unloading-induced atrophy
Showing 5 of 18 shared publications
Megan E. Rosa
University of Arkansas at Fayetteville (US)
17 shared publications
- Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice
- microRNA‐16 Is Downregulated During Insulin Resistance and Controls Skeletal Muscle Protein Accretion
- Differential Responses to Leucine Supplementation in Young and Aged Mice at the Onset of Skeletal Muscle Regeneration
- Sarcopenic Obesity Alters Ecm-related Gene Expression In Mouse Skeletal Muscle
- Timecourse Of Alterations In Myofiber CSA And Oxidative Phenotype In Progression Of Cancer-cachexia
Showing 5 of 17 shared publications
Stavroula Tsitkanou
Beth Israel Deaconess Medical Center
14 shared publications
In database
- Exercise Counteracts the Deleterious Effects of Cancer Cachexia
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- Biological sex divergence in transcriptomic profiles during the onset of hindlimb unloading-induced atrophy
- Myocellular adaptations to short‐term weighted wheel‐running exercise are largely conserved during C26‐tumour induction in male and female mice
Showing 5 of 14 shared publications
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