Jeanne Y. Wei
Department Chairperson
Also affiliated: Boston University (1995–1998); Brigham and Women's Hospital (1986–2000); Mount Sinai Beth Israel (1999); National Institutes of Health (1979–1984); Lehigh Valley Hospital-Pocono (2009); Beth Israel Deaconess Medical Center (1983–2002); Cleveland Clinic (2009); United States Department of Veterans Affairs (1986–1991); Harvard University (1983–2001); Dana (United States) (1988–1994); University of Kentucky (2013); Innsbruck Medical University (2009); Johns Hopkins University (1978–1982); University of Illinois Urbana-Champaign (1982); The University of Texas at San Antonio Health Science Center (2002); Illinois College (1979–1982); Washington University in St. Louis (2009); Adventist HealthCare (2009); University of Arkansas Medical Center (2007–2026); Veterans Health Administration (1992); Hadassah Medical Center (1998); MetroWest Medical Center (1999); Roxbury Community College (1990); Signature Healthcare Brockton Hospital (1990); McLean Hospital (1999); Beth Israel Deaconess Hospital (1982–1997); Harvard University Press (1996–2001); Boston Scientific (United States) (2009); University of Massachusetts Boston (1988); University of Illinois Chicago (1979–1982); Donald W. Reynolds Foundation (2012); Central Arkansas Veterans Healthcare System (2004–2019); Hebrew Home (1986); Mercy Hospital (2009); Geriatric Research Education and Clinical Center (1985–2016); National Institute of Nursing Research (2013); Washington Adventist Hospital (2009); Hebrew SeniorLife (1986–1993); Institute on Aging (1986–2026); National Institute on Aging (1980–1981); Taipei Municipal Jen-Ai Hospital (1979–1987); South Texas Veterans Health Care System (2002); Cardiovascular Research Foundation (2009); Johns Hopkins Hospital (1978–1980); Mercy Angiography Unit (2009); Arkansas Department of Agriculture (2013); University of Baltimore (1978–1979); Massachusetts Institute of Technology (1987)
Faculty Researcher
Department Chairs, College of Medicine
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Jeanne Y. Wei, M.D., Ph.D., is the Jackson T. Stephens Professor of Geriatrics and Chair of the Reynolds Department of Geriatrics at the University of Arkansas for Medical Sciences (UAMS). She also serves as Executive Director of the Reynolds Institute on Aging. Dr. Wei's clinical expertise includes internal medicine, geriatrics, and cardiovascular medicine, and she sees patients at the Thomas and Lyon Longevity Clinic.
Dr. Wei's research career spans over three decades, during which she has maintained continuous NIH funding. Her primary research interests lie in the aging cardiovascular system. Her scholarly work includes numerous publications, with a notable h-index of 57 and over 14,000 citations, reflecting a significant impact in her field. She has also contributed to the scientific community through service on NIH peer review study sections and as chairman of the NIA Board of Scientific Counselors.
Prior to her role at UAMS, Dr. Wei held faculty positions at Harvard Medical School and Beth Israel Hospital in Boston, where she directed the Division on Aging and served as chief of the Gerontology Division at Beth Israel Deaconess Medical Center. She earned her M.D. and Ph.D. from the University of Illinois, followed by residency and fellowship training at Johns Hopkins Hospital and a staff fellowship at the NIH/NIA.
Research Overview
Jeanne Y. Wei, M.D., Ph.D., Jackson T. Stephens Professor of Geriatrics, College of Medicine, University of Arkansas for Medical Sciences (UAMS), is Chair, Reynolds Department of Geriatrics & Executive Director of the Reynolds Institute on Aging (RIOA). Dr. Wei is board certified in internal medicine, geriatrics & cardiovascular medicine and sees patients in the Thomas and Lyon Longevity Clinic at RIOA. After obtaining M.D. and Ph.D. degrees from the University of Illinois, Dr. Wei completed an internal medicine residency and cardiology fellowship at the Johns Hopkins Hospital as well as a staff fellowship in Gerontology at NIH/NIA in Baltimore, MD. She then joined the faculty at Harvard Medical School and Beth Israel Hospital in Boston, and became director of the Division on Aging at Harvard and chief of the Gerontology Division Beth Israel Deaconess Medical Center. In 2002, she joined the faculty at UAMS. She has received continuous NIH funding for more than 30 years. Her major research interests include the aging cardiovascular system. Dr. Wei has served on NIH peer review study sections, National Institute on Aging (NIA) and was chairman of the NIA Board of Scientific Counselors. In addition, she has served on advisory boards of research foundations, pharmaceutical companies and the FDA. She has published more than 200 scientific articles, served on multiple editorial boards and is a reviewer of 34 peer-review scientific journals. She has authored six books, including one geriatrics textbook, and AGING WELL: The Complete Guide to Physical and Emotional Health, a health guide for the general public. Jeanne has more than 35 years of experience in caring for patients, training future geriatricians and cardiologists, conducting geriatric and gerontological research, mentoring geriatric fellows and junior faculty members, and developing academic programs and initiatives. A gifted teacher, Dr. Wei received the 'Outstanding Clinical Educator Award' from Harvard Medical School in 2000 and the 'Outstanding Woman Faculty Award' from the UAMS College of Medicine in 2005. She is recognized nationally and internationally for her contributions to aging research.
Metrics
- h-index: 57
- Publications: 662
- Citations: 14,475
Selected Publications
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Opinions towards Aging in the Marshallese Community residing in Northwest Arkansas (2025)
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RETRACTED: Duloxetine, an SNRI, Targets pSTAT3 Signaling: In-Silico, RNA-Seq and In-Vitro Evidence for a Pleiotropic Mechanism of Pain Relief (2025)
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Mitochondrial Dynamics in Aging Heart (2025)
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Alternative Splicing of Serum Response Factor Reveals Isoform-Specific Remodeling in Cardiac Diseases (2025)
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Differential microRNA profiling of the Marshallese population in Arkansas reveals a higher association with chronic diseases (2025)
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Porphyromonas gingivalis-Lipopolysaccharide Induced Caspase-4 Dependent Noncanonical Inflammasome Activation Drives Alzheimer’s Disease Pathologies (2025)
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Cardiac-specific overexpression of serum response factor regulates age-associated decline in mitochondrial function (2025)
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DIFFERENTIAL EFFECT OF SIRT1 ON MITOCHONDRIAL FUNCTION: INSIGHTS INTO MITOCHONDRIAL RESPIRATORY COMPLEXES (2024)
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P. GINGIVALIS-LPS PROMOTES AD/ADRD VIA CASPASE-4-MEDIATED NONCANONICAL INFLAMMASOME PATHWAY (2024)
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The Long-Term Cardiovascular Risks of Duloxetine Use in Older Adults: A Retrospective Medical Record-Based Adverse Drug Reaction Assessment (2024)
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Missed Insights for Earlier Management of Parkinson’s Disease and the Value of Dopamine Transporter (DAT) Scans (2024)
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Neutrophil Biomarkers Can Predict Cardiotoxicity of Anthracyclines in Breast Cancer (2024)
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The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function (2024)
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RNA sequencing of formalin fixed paraffin-embedded heart tissue provides transcriptomic information about chemotherapy-induced cardiotoxicity (2024)
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Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells (2024)
Grants & Funding
As listed on this researcher's institutional profile.
- Transcription Regulation in the Aging Heart NIH Principal Investigator
- PRagmatic EValuation of evENTS And Benefits of Lipid-lowering in oldEr adults (PREVENTABLE) (IRB 274254) NIH/Nat. Inst. on Aging via Duke University Principal Investigator
- Escitalopram for Agitation in Alzheimer's Disease (S-CitAD) (IRB 274855) NIH/Nat. Inst. on Aging via Johns Hopkins University Principal Investigator
- Predicting CHD Events in Black and White Women NIH Co-Investigator
- Subcontract w/Essential Blends, LLC: UpBeat Phase 2 NIH/Nat. Inst. on Aging via Essential Blends, LLC Co-Investigator
- GLORIA-AF; Global Registry on Long-Term Oral Anti-thrombotic Treatment in Patient Boehringer Ingleheim Pharmaceuticals, Inc. Principal Investigator
- DAABHS SOR III OPAL Narcan Drug Project Substance Abuse & Mental Health Services Administration via Arkansas Department of Human Services Principal Investigator
- Consortium w/Essential: Nutritional Therapy in the Elderly with Heart Failure- Resubmission NIH/Nat. Inst. on Aging via Essential Blends, LLC Co-Investigator
- EFFECT OF AGE ON CARDIOVASCULAR REFLEX FUNCTION NIH Principal Investigator
- State Opioid Response Grant Substance Abuse & Mental Health Services Administration via Arkansas Department of Human Services Principal Investigator
- HARVARD INSTITUTIONAL RESEARCH TRAINING PROGRAM ON AGING NIH Co-Principal Investigator
- Harvard Older Americans Independence Center NIH Co-Principal Investigator
- ORTHOSTATIC HYPOTENSION IN OLDER PERSONS NIH Principal Investigator
- Care Coordination and Home Telehealth Program for Older Adults with Cardiovascular Disease NIH/Nat. Inst. on Aging via Environment and Health Group, Inc. Co-Investigator
- Arkansas Claude Pepper Older Americans Independence Center at UAMS NIH Principal Investigator
- BASIC MECHANISMS OF AGING AND AGE-RELATED DISEASES NIH Principal Investigator
- HARVARD MENTORED CLINICAL SCIENTIST DEVELOPMENT PROGRAM NIH Co-Principal Investigator
- The PREVENTABLE Physical Performance Ancillary Study (Frailty) (IRB 276495) NIH/Nat. Inst. on Aging via Boston VA Research Institute, Inc. Principal Investigator
- GERIATRIC RESEARCH AND TRAINING NIH Principal Investigator
- Sub-Contract with Beth Israel Deaconess Medical Center/Harvard Medical Center: Myocardial Aging and Altered Transcription Regulation (PI Dr. Konstanti NIH/Nat. Inst. on Aging Principal Investigator
- State Targeted Response (STR) No-Cost Extension AR Dept of Human Services/Division of Aging and Adult Services Principal Investigator
- HARVARD NATHAN SHOCK CENTER IN BASIC BIOLOGY OF AGING NIH Co-Principal Investigator
- TCIA Sustainment and Scalability - Platforms for Quantitative Imaging Informatics in Precision Medicine NIH Co-Investigator
Collaboration Network
Top Collaborators
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Daily Consumption of a Specially Formulated Essential Amino Acid-Based Dietary Supplement Improves Physical Performance in Older Adults With Low Physical Functioning
- Alternative Splicing Increases Sirtuin Gene Family Diversity and Modulates Their Subcellular Localization and Function
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
Showing 5 of 32 shared publications
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Alternative Splicing Increases Sirtuin Gene Family Diversity and Modulates Their Subcellular Localization and Function
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells
Showing 5 of 19 shared publications
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells
- Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function
Showing 5 of 16 shared publications
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells
- Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function
Showing 5 of 16 shared publications
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- Mitochondrial Dynamics in Aging Heart
Showing 5 of 11 shared publications
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Disparity and Multimorbidity in Heart Failure Patients Over the Age of 80
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- Quality Improvement in Delirium Health Literacy in Older Adult Patients and Their Caregivers Attending a Geriatric Clinic
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
Showing 5 of 7 shared publications
- Daily Consumption of a Specially Formulated Essential Amino Acid-Based Dietary Supplement Improves Physical Performance in Older Adults With Low Physical Functioning
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Quality Improvement in Delirium Health Literacy in Older Adult Patients and Their Caregivers Attending a Geriatric Clinic
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
- Opinions towards Aging in the Marshallese Community residing in Northwest Arkansas
- A qualitative study of older adults' facilitators, barriers, and cues to action to engage in falls prevention using health belief model constructs
- Older Adults’ Perceptions and Recommendations Regarding a Falls Prevention Self-Management Plan Template Based on the Health Belief Model: A Mixed-Methods Study
- Differential microRNA profiling of the Marshallese population in Arkansas reveals a higher association with chronic diseases
- 21083 Perceptions on the Role of Physical Therapy Providers for Falls Prevention: A Qualitative Investigation
- Opinions towards Aging in the Marshallese Community residing in Northwest Arkansas
- Alternative Splicing Increases Sirtuin Gene Family Diversity and Modulates Their Subcellular Localization and Function
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function
- Sirtuin gene isoforms and genomic sequences of mouse and humans: Divergence across species
- Daily Consumption of a Specially Formulated Essential Amino Acid-Based Dietary Supplement Improves Physical Performance in Older Adults With Low Physical Functioning
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Neutrophil Biomarkers Can Predict Cardiotoxicity of Anthracyclines in Breast Cancer
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
- Differential microRNA profiling of the Marshallese population in Arkansas reveals a higher association with chronic diseases
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Neutrophil Biomarkers Can Predict Cardiotoxicity of Anthracyclines in Breast Cancer
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
- The Long-Term Cardiovascular Risks of Duloxetine Use in Older Adults: A Retrospective Medical Record-Based Adverse Drug Reaction Assessment
- Mitochondrial Dynamics in Aging Heart
- Alternative Splicing of Serum Response Factor Reveals Isoform-Specific Remodeling in Cardiac Diseases
- Duloxetine, an SNRI, Targets pSTAT3 Signaling: In-Silico, RNA-Seq and In-Vitro Evidence for a Pleiotropic Mechanism of Pain Relief
- A qualitative study of older adults' facilitators, barriers, and cues to action to engage in falls prevention using health belief model constructs
- Older Adults’ Perceptions and Recommendations Regarding a Falls Prevention Self-Management Plan Template Based on the Health Belief Model: A Mixed-Methods Study
- 21083 Perceptions on the Role of Physical Therapy Providers for Falls Prevention: A Qualitative Investigation
- A qualitative study of older adults' facilitators, barriers, and cues to action to engage in falls prevention using health belief model constructs
- Older Adults’ Perceptions and Recommendations Regarding a Falls Prevention Self-Management Plan Template Based on the Health Belief Model: A Mixed-Methods Study
- 21083 Perceptions on the Role of Physical Therapy Providers for Falls Prevention: A Qualitative Investigation
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