Stavros C. Manolagas

High Impact

Distinguished Professor

University of Arkansas for Medical Sciences

faculty

Internal Med, College of Medicine

85 h-index 183 pubs 28,859 cited

Research Areas

Links

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OverviewAI-generated summary

Stavros C. Manolagas, Distinguished Professor in Internal Medicine at the University of Arkansas for Medical Sciences, investigates mechanisms of bone loss and potential therapeutic interventions. His recent work has focused on the role of mitochondrial Sirt3 in age-related and estrogen deficiency-induced bone loss, as well as the effects of neutralizing oxidized phospholipids on bone mass in mice. Manolagas's research group has also explored the function of RANK ligand in osteoclast gene expression and the impact of matrix metalloproteinase 13 (Mmp13) deletion in mesenchymal cells on bone mass and cortical bone loss.

Metrics

h-index: 85
Publications: 183
Citations: 28,859

Selected Publications

OR27-02 The Bone Anabolic Effect Of An Antibody Blocking Oxidized Phospholipids Is Associated With An Increase In Wnt10b In Osteoblasts. (2023) DOI
RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression (2023) DOI
Retraction notice to “Deletion of the scavenger receptor Scarb1 in myeloid cells does not affect bone mass” [Bone 170(2023) 116702] (2023) DOI
RETRACTED: Deletion of the scavenger receptor Scarb1 in myeloid cells does not affect bone mass (2023) DOI
Deletion of the Scavenger Receptor Scarb1 in Myeloid Cells Does Not Affect Bone Mass (2022) DOI
Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency (2022) DOI
Mmp13 deletion in mesenchymal cells increases bone mass and attenuates the cortical bone loss caused by estrogen deficiency (2022) DOI
Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass (2022) DOI
Neutralization of oxidized phospholipids attenuates age‐associated bone loss in mice (2021) DOI
<i>Mmp-13</i> deletion in cells of the mesenchymal lineage increases bone mass, decreases endocortical osteoclast number, and attenuates the cortical bone loss caused by estrogen deficiency in mice (2021) DOI
Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency (2021) DOI

Grants & Funding

Role of FoxOs in Skeletal Homeostasis- Resubmission - Continuation-Continuation - Continuation - Continuation NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases Co-Investigator
ESTROGENS AND OSTEOCLASTOGENESIS NIH Principal Investigator
Center for Musculoskeletal Disease Research (CMDR) NIH/Nat. Inst. of General Medical Sciences Co-Investigator
HORMONAL CONTROL OF CYTOKINES IN BONE AND STROMAL CELLS NIH Principal Investigator
Molecular and Cellular Mechanisms of Osteoporosis NIH Principal Investigator
Androgens, estrogens, and bone loss in males NIH Principal Investigator
OSTEOBLAST COMMITMENT AND DIFFERENTIATION BY ANGELS NIH Co-Principal Investigator
1,25 DIHYDROXY VITAMIN D3 AND CELLULAR IMMUNITY NIH Principal Investigator