Match tier
Listed
Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-10-03
M
Maroof Khan Zafar
Research Program Manager
Also affiliated: University of Arkansas Medical Center (2016); American University of Beirut (2022)
Biochemistry & Molecular Biology, College of Medicine
15 h-index
33 pubs
732 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Maroof K. Zafar's research focuses on molecular mechanisms underlying DNA damage, repair, and replication, with a particular emphasis on cancer biology. His work investigates the roles of specific enzymes, such as DNA polymerases and helicases, in cellular processes critical for maintaining genomic stability. Recent publications explore the involvement of DNA Polymerase Kappa in glioblastoma replication and how Dda helicase interacts with DNA. Additionally, his research has examined the impact of inhibiting tryptophan 2,3-dioxygenase on DNA damage tolerance in glioma cells and identified a rare SNP in the HELB gene affecting its cellular function. Zafar also contributes to multi-omics data integration for understanding triple-negative breast cancer and has explored immune system interactions in cancer treatment, as indicated by a publication on anti-PD-L1 induced vision loss. He collaborates with researchers at the University of Arkansas for Medical Sciences and Lyon College.
Metrics
- h-index: 15
- Publications: 33
- Citations: 732
Positions
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Research Program Manager publications 2012–2025University of Arkansas for Medical Sciences Biochemistry & Molecular Biology, College of Medicine Institutional directory
Selected Publications
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Rare SNP in the HELB gene interferes with RPA interaction and cellular function of HELB (2025)
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Rare SNP in the HELB gene interferes with RPA interaction and cellular function of HELB (2024)
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Anti-Programmed Death Ligand-1 Induced Acute Vision Loss in a Patient With Cancer-Associated Retinopathy (2022)
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A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA (2021)
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Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer (2021)
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DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma (2021)
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Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells (2021)
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A Facile Semisynthesis and Evaluation of Garcinoic Acid and Its Analogs for the Inhibition of Human DNA Polymerase β (2020)
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proteiNorm – A User-Friendly Tool for Normalization and Analysis of TMT and Label-Free Protein Quantification (2020)
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Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells (2020)
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The Expression of Human DNA Helicase B Is Affected by G-Quadruplexes in the Promoter (2020)
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Genome Maintenance by DNA Helicase B (2020)
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Multi-Omic Analyses of Growth Cones at Different Developmental Stages Provides Insight into Pathways in Adult Neuroregeneration (2020)
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Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms (2019)
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A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells (2018)
Collaboration Network
Top Collaborators
Robert L. Eoff
University of Arkansas for Medical Sciences
21 shared publications
In database
- Human Rev1 polymerase disrupts G-quadruplex DNA
- Kinetic Analysis of Human PrimPol DNA Polymerase Activity Reveals a Generally Error-Prone Enzyme Capable of Accurately Bypassing 7,8-Dihydro-8-oxo-2′-deoxyguanosine
- Translesion DNA Synthesis in Cancer: Molecular Mechanisms and Therapeutic Opportunities
- Evidence for the Kinetic Partitioning of Polymerase Activity on G-Quadruplex DNA
- Human Translesion Polymerase κ Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA
Showing 5 of 21 shared publications
Amit Ketkar
University of Arkansas for Medical Sciences
18 shared publications
In database
- Human Rev1 polymerase disrupts G-quadruplex DNA
- Kinetic Analysis of Human PrimPol DNA Polymerase Activity Reveals a Generally Error-Prone Enzyme Capable of Accurately Bypassing 7,8-Dihydro-8-oxo-2′-deoxyguanosine
- Evidence for the Kinetic Partitioning of Polymerase Activity on G-Quadruplex DNA
- Human Translesion Polymerase κ Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
Showing 5 of 18 shared publications
Leena Maddukuri
University of Arkansas for Medical Sciences
16 shared publications
In database
- Human Rev1 polymerase disrupts G-quadruplex DNA
- Evidence for the Kinetic Partitioning of Polymerase Activity on G-Quadruplex DNA
- Human Translesion Polymerase κ Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
- Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms
Showing 5 of 16 shared publications
Sarah Eddy
University of Arkansas for Medical Sciences (US)
9 shared publications
- Human Rev1 polymerase disrupts G-quadruplex DNA
- Evidence for the Kinetic Partitioning of Polymerase Activity on G-Quadruplex DNA
- Human Translesion Polymerase κ Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
- The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa
Showing 5 of 9 shared publications
Megan R. Reed
University of Arkansas for Medical Sciences
7 shared publications
In database
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
- Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
Showing 5 of 7 shared publications
Alicia K. Byrd
Winthrop Rockefeller Foundation
7 shared publications
In database
- proteiNorm – A User-Friendly Tool for Normalization and Analysis of TMT and Label-Free Protein Quantification
- Genome Maintenance by DNA Helicase B
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- The Expression of Human DNA Helicase B Is Affected by G-Quadruplexes in the Promoter
- A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA
Showing 5 of 7 shared publications
Peter A. Crooks
University of Arkansas for Medical Sciences
5 shared publications
In database
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
- Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms
- Identification and characterization of novel small molecule inhibitors of the human Y‐family DNA polymerases
- Investigation of Structure‐Activity Relationships for Small‐Molecule Inhibitors of Human DNA Polymerase Eta
- A Novel Small Molecule Inhibitor of Human DNA Polymerase Eta Modulates the Efficacy of Cisplatin in Cancer Cells
Muhammad Z. Chauhan
University of Arkansas for Medical Sciences
4 shared publications
In database
- Multi-Omic Analyses of Growth Cones at Different Developmental Stages Provides Insight into Pathways in Adult Neuroregeneration
- Genome Maintenance by DNA Helicase B
- Anti-Programmed Death Ligand-1 Induced Acute Vision Loss in a Patient With Cancer-Associated Retinopathy
- The Expression of Human DNA Helicase B Is Affected by G-Quadruplexes in the Promoter
Lindsey Hazeslip
University of Arkansas for Medical Sciences
4 shared publications
In database
- Genome Maintenance by DNA Helicase B
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- The Expression of Human DNA Helicase B Is Affected by G-Quadruplexes in the Promoter
- A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA
Stephanie D. Byrum
Arkansas Children's Hospital
4 shared publications
In database
- proteiNorm – A User-Friendly Tool for Normalization and Analysis of TMT and Label-Free Protein Quantification
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
Matthew D. Thompson
University of Arkansas for Medical Sciences
4 shared publications
In database
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA
- Rare SNP in the HELB gene interferes with RPA interaction and cellular function of HELB
- Rare SNP in the HELB gene interferes with RPA interaction and cellular function of HELB
Surajit Banerjee
Argonne National Laboratory (US)
3 shared publications
- Leukotriene Biosynthesis Inhibitor MK886 Impedes DNA Polymerase Activity
- A Nucleotide-Analogue-Induced Gain of Function Corrects the Error-Prone Nature of Human DNA Polymerase iota
- Differential Furanose Selection in the Active Sites of Archaeal DNA Polymerases Probed by Fixed-Conformation Nucleotide Analogues
Martin Egli
Vanderbilt University (US)
3 shared publications
- Leukotriene Biosynthesis Inhibitor MK886 Impedes DNA Polymerase Activity
- A Nucleotide-Analogue-Induced Gain of Function Corrects the Error-Prone Nature of Human DNA Polymerase iota
- Differential Furanose Selection in the Active Sites of Archaeal DNA Polymerases Probed by Fixed-Conformation Nucleotide Analogues
Narsimha Reddy Penthala
University of Arkansas for Medical Sciences
3 shared publications
In database
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
- Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms
- Identification and characterization of novel small molecule inhibitors of the human Y‐family DNA polymerases
April C.L. Bostian
Arkansas State University
3 shared publications
In database
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- Inhibition of Kynurenine Signaling Decreases Glioblastoma Multiforme Genomic Instability and Sensitizes Cells to Chemotherapeutic Treatment
Similar Researchers
Based on overlapping research topics
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University of Arkansas for Medical Sciences
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