Maroof K. Zafar

Research Program Manager

UAMS primary UA Little Rock

Also affiliated: American University of Beirut (2022)

Staff Researcher

Biochemistry & Molecular Biology, College of Medicine

15 h-index 33 pubs 723 cited

Research Areas

Biomedical Subjects

Links

Research Group UAMS TRI Profile

OverviewAI-generated summary

Maroof K. Zafar's research focuses on molecular mechanisms underlying DNA damage, repair, and replication, with a particular emphasis on cancer biology. His work investigates the roles of specific enzymes, such as DNA polymerases and helicases, in cellular processes critical for maintaining genomic stability. Recent publications explore the involvement of DNA Polymerase Kappa in glioblastoma replication and how Dda helicase interacts with DNA. Additionally, his research has examined the impact of inhibiting tryptophan 2,3-dioxygenase on DNA damage tolerance in glioma cells and identified a rare SNP in the HELB gene affecting its cellular function. Zafar also contributes to multi-omics data integration for understanding triple-negative breast cancer and has explored immune system interactions in cancer treatment, as indicated by a publication on anti-PD-L1 induced vision loss. He collaborates with researchers at the University of Arkansas for Medical Sciences and Lyon College.

Metrics

h-index: 15
Publications: 33
Citations: 723

Selected Publications

Rare SNP in the HELB gene interferes with RPA interaction and cellular function of HELB (2025)

NAR Molecular Medicine DOI OpenAlex
Rare SNP in the HELB gene interferes with RPA interaction and cellular function of HELB (2024)

bioRxiv (Cold Spring Harbor Laboratory) DOI OpenAlex
Anti-Programmed Death Ligand-1 Induced Acute Vision Loss in a Patient With Cancer-Associated Retinopathy (2022)

Cureus 15 citations DOI OpenAlex
A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from <scp>DNA</scp> (2021)

Protein Science 8 citations DOI OpenAlex
Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer (2021)

Molecular Omics 17 citations DOI OpenAlex
DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma (2021)

The FASEB Journal 1 citation DOI OpenAlex
Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells (2021)

NAR Cancer 16 citations DOI OpenAlex
A Facile Semisynthesis and Evaluation of Garcinoic Acid and Its Analogs for the Inhibition of Human DNA Polymerase β (2020)

Molecules 6 citations DOI OpenAlex
proteiNorm – A User-Friendly Tool for Normalization and Analysis of TMT and Label-Free Protein Quantification (2020)

ACS Omega 177 citations DOI OpenAlex
Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells (2020)

bioRxiv (Cold Spring Harbor Laboratory) 2 citations DOI OpenAlex
The Expression of Human DNA Helicase B Is Affected by G-Quadruplexes in the Promoter (2020)

Biochemistry 9 citations DOI OpenAlex
Genome Maintenance by DNA Helicase B (2020)

Genes 27 citations DOI OpenAlex
Multi-Omic Analyses of Growth Cones at Different Developmental Stages Provides Insight into Pathways in Adult Neuroregeneration (2020)

iScience 34 citations DOI OpenAlex
Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms (2019)

ACS Chemical Biology 21 citations DOI OpenAlex
A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells (2018)

Biochemistry 35 citations DOI OpenAlex