Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
P
Pankaj Patyal
Assistant Staff Scientist
Also affiliated: Wright State University (2015–2016)
9 h-index
36 pubs
315 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Pankaj Patyal's research focuses on the molecular mechanisms underlying neuroinflammation and mitochondrial dysfunction, particularly in the context of neurodegenerative diseases. His work investigates the role of bacterial components, such as lipopolysaccharides from *Porphyromonas gingivalis*, in initiating inflammatory responses that impact neuronal health. Patyal also explores how metabolic factors, like valine supplementation, can modulate mitochondrial function and protect against oxidative stress.
His recent publications examine the impact of *P. gingivalis*-LPS on mitochondrial dysfunction and neuroinflammation, utilizing cell cultures and proteomic analysis. Additionally, his research delves into the regulation of mitochondrial functions by the Rho/SRF transcription pathway and its inhibitors. Patyal has been actively involved in studies related to specific genetic deletions and their correlation with neurological disease traits in females and has contributed to the development of transgenic mouse models for studying nervous system cell populations. His work is supported by collaborations with researchers at the University of Arkansas for Medical Sciences, including Ambika Verma and Gohar Azhar.
Metrics
- h-index: 9
- Publications: 36
- Citations: 315
Positions
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Assistant Staff Scientist 2026–presentUniversity of Arkansas for Medical Sciences Department of Geriatrics ORCID
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Postdoctoral fellow 2021–2026University of Arkansas for Medical Sciences Department of Geriatrics ORCID
Selected Publications
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Nuclear transcriptional regulation of mitochondria in the aging heart: From mechanisms to targeted therapeutic strategies (2026)
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Biology of Aging I Antisense Oligonucleotide-Mediated SRF Reduction Ameliorates Mitochondrial Dysfunction in Cardiac Aging (2025)
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P. gingivalis-LPS Activates the Alzheimer’s Disease-Associated Amyloid Secretase Pathway via Caspase-4 (2025)
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Mitochondrial Dynamics in Aging Heart (2025)
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Differential microRNA profiling of the Marshallese population in Arkansas reveals a higher association with chronic diseases (2025)
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Porphyromonas gingivalis-Lipopolysaccharide Induced Caspase-4 Dependent Noncanonical Inflammasome Activation Drives Alzheimer’s Disease Pathologies (2025)
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Cardiac-specific overexpression of serum response factor regulates age-associated decline in mitochondrial function (2025)
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CARDIAC SPECIFIC OVEREXPRESSION OF SERUM RESPONSE FACTOR ALTERS MITOCHONDRIAL STRUCTURE AND FUNCTION (2024)
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DIFFERENTIAL EFFECT OF SIRT1 ON MITOCHONDRIAL FUNCTION: INSIGHTS INTO MITOCHONDRIAL RESPIRATORY COMPLEXES (2024)
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DIFFERENTIAL MICRORNAS PROFILING OF MARSHALLESE IN ARKANSAS IS ASSOCIATED WITH CHRONIC DISEASES OF AGING (2024)
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P. GINGIVALIS-LPS PROMOTES AD/ADRD VIA CASPASE-4-MEDIATED NONCANONICAL INFLAMMASOME PATHWAY (2024)
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The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function (2024)
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Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells (2024)
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Deletion of Interleukin-1β Converting Enzyme Alters Mouse Cardiac Structure and Function (2024)
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Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome (2024)
Collaboration Network
Top Collaborators
Gohar Azhar
Institute on Aging
25 shared publications
In database
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells
- Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function
Showing 5 of 25 shared publications
Jeanne Y. Wei
Institute on Aging
25 shared publications
In database
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells
- Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function
Showing 5 of 25 shared publications
Ambika Verma
University of Arkansas for Medical Sciences
23 shared publications
In database
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells
- Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function
Showing 5 of 23 shared publications
Xiaomin Zhang
Institute on Aging (US)
17 shared publications
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells
- Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function
Showing 5 of 17 shared publications
Shakshi Sharma
Institute on Aging
9 shared publications
In database
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Mitochondrial Dynamics in Aging Heart
- The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
Showing 5 of 9 shared publications
P.A.L. Wight
University of Arkansas for Medical Sciences
7 shared publications
In database
- Xq22 deletions and correlation with distinct neurological disease traits in females: Further evidence for a contiguous gene syndrome
- A Transgenic Mouse Model to Selectively Identify α3 Na,K-ATPase Expressing Cells in the Nervous System
- The wmN1 enhancer region in intron 1 is required for expression of human PLP1
- Plp1 in the enteric nervous system is preferentially expressed during early postnatal development in mouse as DM20, whose expression appears reliant on an intronic enhancer
- The wmN1 Enhancer Region of the Mouse Myelin Proteolipid Protein Gene (mPlp1) is Indispensable for Expression of an mPlp1-lacZ Transgene in Both the CNS and PNS
Showing 5 of 7 shared publications
Yingni Che
Institute on Aging
6 shared publications
In database
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
Showing 5 of 6 shared publications
Robert R. Wolfe
Institute on Aging
4 shared publications
In database
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
- EAAS AND WHEY PROTEIN MAY IMPROVE PHYSICAL FUNCTION OF OLDER ADULTS INDEPENDENTLY OF GUT MICROBIOME
Neriman T. Kockara
University of Arkansas for Medical Sciences
3 shared publications
In database
- A Transgenic Mouse Model to Selectively Identify α3 Na,K-ATPase Expressing Cells in the Nervous System
- The wmN1 enhancer region in intron 1 is required for expression of human PLP1
- The wmN1 Enhancer Region of the Mouse Myelin Proteolipid Protein Gene (mPlp1) is Indispensable for Expression of an mPlp1-lacZ Transgene in Both the CNS and PNS
Fathima S. Ameer
Institute on Aging
3 shared publications
In database
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function
- SIRTUIN 1 ISOFORMS DIFFERENTIALLY IMPACT MITOCHONDRIAL GENE EXPRESSION AND FUNCTION IN MUSCLE CELLS
Grishma KC
Institute on Aging
3 shared publications
In database
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
Amanda Pangle
Institute on Aging
3 shared publications
In database
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
Wei Zhang
University of Arkansas at Little Rock
3 shared publications
In database
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
- Differential microRNA profiling of the Marshallese population in Arkansas reveals a higher association with chronic diseases
Jyotsna Shrivastava
Institute on Aging
3 shared publications
In database
- Mitochondrial Dynamics in Aging Heart
- The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function
- DIFFERENTIAL EFFECT OF SIRT1 ON MITOCHONDRIAL FUNCTION: INSIGHTS INTO MITOCHONDRIAL RESPIRATORY COMPLEXES
Hamdan Hamdan
University of Arkansas for Medical Sciences (US)
2 shared publications
- The wmN1 enhancer region in intron 1 is required for expression of human PLP1
- PLP1-lacZ transgenic mice reveal that splice variants containing “human-specific” exons are relatively minor in comparison to the archetypal transcript and that an upstream regulatory element bolsters expression during early postnatal brain development
Similar Researchers
Based on overlapping research topics
Ambika Verma
University of Arkansas for Medical Sciences
Neuroinflammation and Neurodegeneration Mechanisms
Mitochondrial Function and Pathology
Host-Pathogen Interactions
Samantha D. Crane
University of Arkansas for Medical Sciences
Host-Pathogen Interactions
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Geetika KC
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Yamin Meng
University of Arkansas for Medical Sciences
Host-Pathogen Interactions
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Zoya Faruqui
University of Arkansas at Little Rock
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Ravi Kr. Gupta
University of Arkansas for Medical Sciences
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