Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-15
P
Pankaj Patyal
Researcher
Also affiliated: Wright State University (2015–2016); Institute on Aging (2022–2026)
Faculty Researcher
8 h-index
36 pubs
295 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Pankaj Patyal's research focuses on the mechanisms underlying neuroinflammatory diseases, particularly their connection to mitochondrial dysfunction and oxidative stress. His work investigates the role of specific bacterial components, such as lipopolysaccharides from *Porphyromonas gingivalis*, in triggering these processes. Patyal has explored how these triggers can lead to the activation of inflammasomes and contribute to Alzheimer's disease pathologies. His research also examines the influence of cellular pathways, like the Rho/SRF transcription pathway, and specific nutrients, such as valine, on mitochondrial function and cellular protection against oxidative damage. Patyal collaborates extensively with researchers at the University of Arkansas for Medical Sciences, including Ambika Verma and Gohar Azhar, with whom he shares multiple publications. His scholarship metrics include an h-index of 8 with 279 total citations across 36 publications.
Metrics
- h-index: 8
- Publications: 36
- Citations: 295
Selected Publications
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Nuclear transcriptional regulation of mitochondria in the aging heart: From mechanisms to targeted therapeutic strategies (2026)
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Biology of Aging I Antisense Oligonucleotide-Mediated SRF Reduction Ameliorates Mitochondrial Dysfunction in Cardiac Aging (2025)
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P. gingivalis-LPS Activates the Alzheimer’s Disease-Associated Amyloid Secretase Pathway via Caspase-4 (2025)
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Mitochondrial Dynamics in Aging Heart (2025)
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Differential microRNA profiling of the Marshallese population in Arkansas reveals a higher association with chronic diseases (2025)
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Porphyromonas gingivalis-Lipopolysaccharide Induced Caspase-4 Dependent Noncanonical Inflammasome Activation Drives Alzheimer’s Disease Pathologies (2025)
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Cardiac-specific overexpression of serum response factor regulates age-associated decline in mitochondrial function (2025)
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CARDIAC SPECIFIC OVEREXPRESSION OF SERUM RESPONSE FACTOR ALTERS MITOCHONDRIAL STRUCTURE AND FUNCTION (2024)
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DIFFERENTIAL EFFECT OF SIRT1 ON MITOCHONDRIAL FUNCTION: INSIGHTS INTO MITOCHONDRIAL RESPIRATORY COMPLEXES (2024)
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DIFFERENTIAL MICRORNAS PROFILING OF MARSHALLESE IN ARKANSAS IS ASSOCIATED WITH CHRONIC DISEASES OF AGING (2024)
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P. GINGIVALIS-LPS PROMOTES AD/ADRD VIA CASPASE-4-MEDIATED NONCANONICAL INFLAMMASOME PATHWAY (2024)
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The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function (2024)
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Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells (2024)
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Deletion of Interleukin-1β Converting Enzyme Alters Mouse Cardiac Structure and Function (2024)
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Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome (2024)
Collaboration Network
Top Collaborators
Jeanne Y. Wei
University of Arkansas for Medical Sciences
24 shared publications
In database
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells
- Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function
Showing 5 of 24 shared publications
Ambika Verma
University of Arkansas for Medical Sciences
23 shared publications
In database
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells
- Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function
Showing 5 of 23 shared publications
Gohar Azhar
Institute on Aging
22 shared publications
In database
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells
- Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function
Showing 5 of 22 shared publications
Xiaomin Zhang
Institute on Aging (US)
17 shared publications
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells
- Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function
Showing 5 of 17 shared publications
Shakshi Sharma
Institute on Aging
9 shared publications
In database
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- Mitochondrial Dynamics in Aging Heart
Showing 5 of 9 shared publications
Robert R. Wolfe
University of Arkansas for Medical Sciences
4 shared publications
In database
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
- EAAS AND WHEY PROTEIN MAY IMPROVE PHYSICAL FUNCTION OF OLDER ADULTS INDEPENDENTLY OF GUT MICROBIOME
Fathima S. Ameer
Institute on Aging
3 shared publications
In database
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function
- SIRTUIN 1 ISOFORMS DIFFERENTIALLY IMPACT MITOCHONDRIAL GENE EXPRESSION AND FUNCTION IN MUSCLE CELLS
Grishma KC
Institute on Aging
3 shared publications
In database
- Valine improves mitochondrial function and protects against oxidative stress
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
Yingni Che
University of Arkansas for Medical Sciences
3 shared publications
In database
- P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress
- Rho/SRF Inhibitor Modulates Mitochondrial Functions
- SIRTUIN 1 ISOFORMS DIFFERENTIALLY IMPACT MITOCHONDRIAL GENE EXPRESSION AND FUNCTION IN MUSCLE CELLS
Amanda Pangle
Institute on Aging
3 shared publications
In database
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
Wei Zhang
University of Arkansas at Little Rock
3 shared publications
In database
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
- Differential microRNA profiling of the Marshallese population in Arkansas reveals a higher association with chronic diseases
Yingni Che
University of Arkansas for Medical Sciences
3 shared publications
In database
- Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
- Short‐Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome
- Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults
Jyotsna Shrivastava
Institute on Aging
3 shared publications
In database
- The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function
- Mitochondrial Dynamics in Aging Heart
- DIFFERENTIAL EFFECT OF SIRT1 ON MITOCHONDRIAL FUNCTION: INSIGHTS INTO MITOCHONDRIAL RESPIRATORY COMPLEXES
Daniel Fil
University of Arkansas for Medical Sciences
2 shared publications
In database
- Plp1 in the enteric nervous system is preferentially expressed during early postnatal development in mouse as DM20, whose expression appears reliant on an intronic enhancer
- PLP1-lacZ transgenic mice reveal that splice variants containing “human-specific” exons are relatively minor in comparison to the archetypal transcript and that an upstream regulatory element bolsters expression during early postnatal brain development
P.A.L. Wight
University of Arkansas for Medical Sciences
2 shared publications
In database
- Plp1 in the enteric nervous system is preferentially expressed during early postnatal development in mouse as DM20, whose expression appears reliant on an intronic enhancer
- PLP1-lacZ transgenic mice reveal that splice variants containing “human-specific” exons are relatively minor in comparison to the archetypal transcript and that an upstream regulatory element bolsters expression during early postnatal brain development
Similar Researchers
Based on overlapping research topics
Ambika Verma
University of Arkansas for Medical Sciences
Mitochondrial Function and Pathology
Neuroinflammation and Neurodegeneration Mechanisms
Host-Pathogen Interactions
Het Adhvaryu
University of Arkansas for Medical Sciences
Mitochondrial Function and Pathology
Host-Pathogen Interactions
Disease Models, Animal
Fischer Huey
University of Arkansas for Medical Sciences
Mitochondrial Function and Pathology
Host-Pathogen Interactions
Disease Models, Animal
Sharda P. Singh
University of Arkansas for Medical Sciences
Mitochondrial Function and Pathology
Neuroinflammation and Neurodegeneration Mechanisms
Oxidative Stress
Zoya Faruqui
University of Arkansas at Little Rock
Host-Pathogen Interactions
Disease Models, Animal
Microbial infections and disease research
Rokeya Akter
University of Arkansas at Fayetteville
Host-Pathogen Interactions
Disease Models, Animal
Microbial infections and disease research