Gunnar Boysen Institution Verified

Sourced from institutional research profiles (UAMS TRI or ARA).

Federal Grant PI High Impact

Associate Professor -tenured

University of Arkansas for Medical Sciences

faculty

32 h-index 137 pubs 3,509 cited

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OverviewAI-generated summary

Gunnar Boysen's research program at the University of Arkansas for Medical Sciences investigates the complex interactions between chemical exposures and an individual's nutritional status and lifestyle habits, including diet and physical activity. His work employs DNA and protein adducts as biomarkers to examine carcinogen metabolism, how it is influenced by dietary components, and the underlying mechanisms that regulate the activity of relevant enzymes. This research is supported by a $719,050 grant from the NIH/National Institute of Environmental Health Sciences focused on understanding the origins of the mutational landscape in cancer.

Boysen also utilizes mass spectrometry-based metabolomic approaches, both targeted and untargeted, to study alterations in common metabolic pathways that result from environmental exposures. His recent publications cover a range of topics including methodologies for DNA adducts, the application of nanopore sequencing in glioma characterization, the origins of mutational signatures in cancer, and the characterization of protein adducts derived from 1,3-butadiene. He also has published on the bioactivation risks of diphenylamine NSAIDs and the role of CYP enzymes in their metabolism, as well as the lung metabolome of exposed mice.

With an h-index of 32 and over 3,500 citations across 137 publications, Boysen is recognized as a high-impact researcher. He actively collaborates with colleagues at the University of Arkansas for Medical Sciences, including Grover Miller, Azemat Jamshidi‐Parsian, Nadia I. Georgieva, and Intawat Nookaew, with whom he has co-authored multiple publications.

Metrics

h-index: 32
Publications: 137
Citations: 3,509

Selected Publications

Sex-Specific Formation of 1,2:3,4-Diepoxybutane-Derived Hemoglobin Adducts in 1,3-Butadiene-Exposed Workers (2025) DOI
Human health risk assessment for exposures to 1,3-butadiene in the United States with input from an independent science advisory panel (2025) DOI
Investigating the origins of the mutational signatures in cancer (2025) DOI
Generation of BT-Amide, a Bone-Targeted Pyk2 Inhibitor, Effective <i>via</i> Oral Administration, for the Prevention of Glucocorticoid-Induced Bone Loss (2024) DOI
Acquired Radiation Resistance Induces Thiol-dependent Cisplatin Cross-resistance (2023) DOI
Climate Change and New Challenges for Rural Communities: Particulate Matter Matters (2023) DOI
Acquired Radiation Resistance Induces Thiol-dependent Cisplatin Cross-resistance (2023) DOI
Exploiting nanopore sequencing for characterization and grading of <i>IDH</i>‐mutant gliomas (2023) DOI
Similar 5F-APINACA Metabolism between CD-1 Mouse and Human Liver Microsomes Involves Different P450 Cytochromes (2022) DOI
Characterization of population variability of 1,3-butadiene derived protein adducts in humans and mice (2022) DOI
Nanopore Sequencing for Detection and Characterization of Phosphorothioate Modifications in Native DNA Sequences (2022) DOI
Current and Future Methodology for Quantitation and Site-Specific Mapping the Location of DNA Adducts (2022) DOI
Current and Future Methodology for Quantitation and Site-specific Mapping the Location of DNA Adducts (2021) DOI
DEB‐FAPy‐dG Adducts of 1,3‐Butadiene: Synthesis, Structural Characterization, and Formation in 1,2,3,4‐Diepoxybutane Treated DNA** (2021) DOI
CYP2C9 and 3A4 play opposing roles in bioactivation and detoxification of diphenylamine NSAIDs (2021) DOI