Sean D. Taverna
Professor
Also affiliated: Johns Hopkins University (2009–2026); University of Virginia Health System (2001–2004); Johns Hopkins Medicine (2009–2022); Massachusetts General Hospital (2003); Arkansas Children's Research Institute (2021); Saint Louis University (2001); University of Virginia (2002–2007); Rockefeller University (2003–2008); Walter Reed Army Institute of Research (2022)
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Sean D. Taverna's research program focuses on understanding the mechanisms by which chromatin structure is regulated and how these regulatory events influence gene expression. His work has investigated the roles of histone modifications, such as methylation and acetylation, and the proteins that recognize these modifications in various biological contexts. He has studied the specificity of chromo domain interactions with methylated histone H3, and how specific histone modifications at lysine 4 of histone H3 can promote transcriptional activity.
His research has also explored programmed DNA elimination in organisms like *Tetrahymena thermophila*, examining the link between histone H3 methylation and these processes. Taverna's laboratory has also investigated the association of histone modifications with gene loci poised for rearrangement, such as antigen receptor loci involved in V(D)J recombination. His publications include work on the structure of the germline genome of *Tetrahymena thermophila* and its relationship to the rearranged somatic genome.
Taverna holds an h-index of 30 and has authored over 700 publications with more than 5,000 citations. He has collaborated with researchers at the University of Arkansas for Medical Sciences, including Kimberly Stephens, Bryan E. White, Brian Koss, and Michael Bauer.
Metrics
- h-index: 30
- Publications: 843
- Citations: 5,093
Positions
-
Professor 2023–presentUniversity of Arkansas for Medical Sciences Biochemistry and Molecular Biology ORCID
Selected Publications
-
Abstract 6545: Characterizing ATF6 activation-driven mechanisms improving ICB efficacy (2026)
-
Global Mapping of Combinatorial Chromatin Regulatory Events Using Hi-Plex CUT&Tag (2025)
-
Bromodomain proteins IBD1 and IBD2 link histone acetylation to SWR1- and INO80-mediated H2A.Z regulation in Tetrahymena (2025)
-
EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma (2025)
-
Molecular insight into interactions between the Taf14, Yng1 and Sas3 subunits of the NuA3 complex (2024)
-
De novo methylation of histone H3K23 by the methyltransferases EHMT1/GLP and EHMT2/G9a (2022)
-
Transcription Factor Affinity at Dorsal Root Ganglia Enhancers after Nerve Injury (2022)
-
Dynamics of global gene expression and chromatin accessibility of the peripheral nervous system in animal models of persistent pain (2021)
Collaboration Network
Top Collaborators
- Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini
- Purification of a specific native genomic locus for proteomic analysis
- Mapping the local protein interactome of the NuA3 histone acetyltransferase
- Quantitative Analysis of Histone Exchange during Chromatin Purification
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
Showing 5 of 6 shared publications
- De novo methylation of histone H3K23 by the methyltransferases EHMT1/GLP and EHMT2/G9a
- Dynamics of global gene expression and chromatin accessibility of the peripheral nervous system in animal models of persistent pain
- Transcription Factor Affinity at Dorsal Root Ganglia Enhancers after Nerve Injury
- Dynamics of global gene expression and chromatin accessibility of the peripheral nervous system in animal models of persistent pain
- Transcription Factor Affinity at Dorsal Root Ganglia Enhancers after Nerve Injury
- Global Mapping of Combinatorial Chromatin Regulatory Events Using Hi-Plex CUT&Tag
- Purification of a specific native genomic locus for proteomic analysis
- Quantitative Analysis of Histone Exchange during Chromatin Purification
- Mapping the local protein interactome of the NuA3 histone acetyltransferase
- Quantitative Analysis of Histone Exchange during Chromatin Purification
- Mapping the local protein interactome of the NuA3 histone acetyltransferase
- Quantitative Analysis of Histone Exchange during Chromatin Purification
- Dynamics of global gene expression and chromatin accessibility of the peripheral nervous system in animal models of persistent pain
- Transcription Factor Affinity at Dorsal Root Ganglia Enhancers after Nerve Injury
- Dynamics of global gene expression and chromatin accessibility of the peripheral nervous system in animal models of persistent pain
- Transcription Factor Affinity at Dorsal Root Ganglia Enhancers after Nerve Injury
- Dynamics of global gene expression and chromatin accessibility of the peripheral nervous system in animal models of persistent pain
- Transcription Factor Affinity at Dorsal Root Ganglia Enhancers after Nerve Injury
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract 6545: Characterizing ATF6 activation-driven mechanisms improving ICB efficacy
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract 6545: Characterizing ATF6 activation-driven mechanisms improving ICB efficacy
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract 6545: Characterizing ATF6 activation-driven mechanisms improving ICB efficacy
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract 6545: Characterizing ATF6 activation-driven mechanisms improving ICB efficacy
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract 6545: Characterizing ATF6 activation-driven mechanisms improving ICB efficacy
- Quantitative Analysis of Histone Exchange during Chromatin Purification
Similar Researchers
Based on overlapping research topics