Sean D. Taverna
Professor
Also affiliated: University of Maryland, Baltimore (2017); Arkansas Children's Hospital (2021); Johns Hopkins University (2009–2025); University of Virginia Health System (2001–2004); Johns Hopkins Medicine (2009–2025); Massachusetts General Hospital (2003); Johns Hopkins Hospital (2011); Sidney Kimmel Comprehensive Cancer Center (2014); Saint Louis University (2001); University of Virginia (2007); University of Baltimore (2011–2014); Rockefeller University (2003–2008); Walter Reed Army Institute of Research (2022)
Faculty Researcher
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Sean D. Taverna's research focuses on understanding the molecular mechanisms underlying epigenetic regulation, particularly the role of histone modifications in cellular processes and disease. His work investigates how proteins interact to control gene expression and how these processes are altered in various biological contexts, including development and disease states.
Taverna's laboratory has published research on the de novo methylation of histone H3K23 by specific methyltransferases, exploring the enzymes EHMT1/GLP and EHMT2/G9a. His group also studies the function of bromodomain proteins in linking histone acetylation to chromatin remodeling complexes, as demonstrated in their work on IBD1 and IBD2 in *Tetrahymena*. Furthermore, his research has explored the impact of epigenetic changes on gene expression and chromatin accessibility in animal models of persistent pain, and the role of Polycomb repressive complexes in RNAi-mediated heterochromatin formation.
His scholarship has resulted in 95 publications, with a citation count of 4,969 and an h-index of 30, designating him as a highly cited researcher. Taverna collaborates with several colleagues at the University of Arkansas for Medical Sciences, including Kimberly Stephens (30 shared publications), Bryan E. White (3 shared publications), Brian Koss (1 shared publication), and Michael Bauer (1 shared publication). He maintains an active laboratory website to share his research.
Metrics
- h-index: 30
- Publications: 95
- Citations: 5,009
Selected Publications
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Abstract 6545: Characterizing ATF6 activation-driven mechanisms improving ICB efficacy (2026)
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Global Mapping of Combinatorial Chromatin Regulatory Events Using Hi-Plex CUT&Tag (2025)
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Bromodomain proteins IBD1 and IBD2 link histone acetylation to SWR1- and INO80-mediated H2A.Z regulation in Tetrahymena (2025)
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EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma (2025)
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Molecular insight into interactions between the Taf14, Yng1 and Sas3 subunits of the NuA3 complex (2024)
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De novo methylation of histone H3K23 by the methyltransferases EHMT1/GLP and EHMT2/G9a (2022)
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Transcription Factor Affinity at Dorsal Root Ganglia Enhancers after Nerve Injury (2022)
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Dynamics of global gene expression and chromatin accessibility of the peripheral nervous system in animal models of persistent pain (2021)
Collaboration Network
Top Collaborators
- De novo methylation of histone H3K23 by the methyltransferases EHMT1/GLP and EHMT2/G9a
- Dynamics of global gene expression and chromatin accessibility of the peripheral nervous system in animal models of persistent pain
- Transcription Factor Affinity at Dorsal Root Ganglia Enhancers after Nerve Injury
- Dynamics of global gene expression and chromatin accessibility of the peripheral nervous system in animal models of persistent pain
- Transcription Factor Affinity at Dorsal Root Ganglia Enhancers after Nerve Injury
- Global Mapping of Combinatorial Chromatin Regulatory Events Using Hi-Plex CUT&Tag
- Dynamics of global gene expression and chromatin accessibility of the peripheral nervous system in animal models of persistent pain
- Transcription Factor Affinity at Dorsal Root Ganglia Enhancers after Nerve Injury
- Dynamics of global gene expression and chromatin accessibility of the peripheral nervous system in animal models of persistent pain
- Transcription Factor Affinity at Dorsal Root Ganglia Enhancers after Nerve Injury
- Dynamics of global gene expression and chromatin accessibility of the peripheral nervous system in animal models of persistent pain
- Transcription Factor Affinity at Dorsal Root Ganglia Enhancers after Nerve Injury
- Dynamics of global gene expression and chromatin accessibility of the peripheral nervous system in animal models of persistent pain
- Transcription Factor Affinity at Dorsal Root Ganglia Enhancers after Nerve Injury
- Transcription Factor Affinity at Dorsal Root Ganglia Enhancers after Nerve Injury
- Transcription Factor Affinity at Dorsal Root Ganglia Enhancers after Nerve Injury
- Transcription Factor Affinity at Dorsal Root Ganglia Enhancers after Nerve Injury
- De novo methylation of histone H3K23 by the methyltransferases EHMT1/GLP and EHMT2/G9a
- De novo methylation of histone H3K23 by the methyltransferases EHMT1/GLP and EHMT2/G9a
- De novo methylation of histone H3K23 by the methyltransferases EHMT1/GLP and EHMT2/G9a
- De novo methylation of histone H3K23 by the methyltransferases EHMT1/GLP and EHMT2/G9a
- De novo methylation of histone H3K23 by the methyltransferases EHMT1/GLP and EHMT2/G9a
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