Sean D. Taverna

High Impact

Professor

University of Arkansas for Medical Sciences

faculty

30 h-index 94 pubs 4,880 cited

Research Areas

Epigenetics and DNA Methylation Genomics and Chromatin Dynamics Cancer-related molecular mechanisms research Molecular Biology Techniques and Applications Neuroscience and Neuropharmacology Research Protein Structure and Dynamics Immune Response and Inflammation

Links

ORCID Lab Website

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OverviewAI-generated summary

Sean D. Taverna's research investigates molecular mechanisms of gene regulation, focusing on chromatin structure and epigenetic modifications. His work examines the role of Polycomb repressive complexes in RNAi-mediated heterochromatin formation and the dynamic distribution of nuclear bodies. Taverna also studies the de novo methylation of histone H3K23 by specific methyltransferases, EHMT1/GLP and EHMT2/G9a.

His research extends to the peripheral nervous system, exploring global gene expression and chromatin accessibility in animal models of persistent pain. Taverna's publications also address cancer-related molecular mechanisms, including the impact of EZH2 loss during metabolic stress on MHC class I machinery restoration in melanoma. He has also investigated molecular interactions within protein complexes, such as the NuA3 complex, and developed methods for global mapping of combinatorial chromatin regulatory events using techniques like Hi-Plex CUT&Tag.

Taverna collaborates with researchers at the University of Arkansas for Medical Sciences, including Kimberly Stephens, Bryan E. White, Brian Koss, and Michael Bauer. He has an h-index of 30 with 4,880 citations across 94 publications, and is recognized as a highly cited researcher.

Metrics

  • h-index: 30
  • Publications: 94
  • Citations: 4,880

Selected Publications

  • Global Mapping of Combinatorial Chromatin Regulatory Events Using Hi-Plex CUT&Tag (2025) DOI
  • Bromodomain proteins IBD1 and IBD2 link histone acetylation to SWR1- and INO80-mediated H2A.Z regulation in Tetrahymena (2025) DOI
  • EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma (2025) DOI
  • Molecular insight into interactions between the Taf14, Yng1 and Sas3 subunits of the NuA3 complex (2024) DOI
  • De novo methylation of histone H3K23 by the methyltransferases EHMT1/GLP and EHMT2/G9a (2022) DOI
  • Transcription Factor Affinity at Dorsal Root Ganglia Enhancers after Nerve Injury (2022) DOI
  • Dynamics of global gene expression and chromatin accessibility of the peripheral nervous system in animal models of persistent pain (2021) DOI

Collaborators

Researchers in the database who share publications

Kimberly Stephens University of Arkansas for Medical Sciences 30 shared publications Bryan E. White University of Arkansas for Medical Sciences 3 shared publications Brian Koss University of Arkansas for Medical Sciences 1 shared publication Michael Bauer University of Arkansas for Medical Sciences 1 shared publication Alan J. Tackett University of Arkansas for Medical Sciences 1 shared publication Nathan Avaritt University of Arkansas for Medical Sciences 1 shared publication Megan R. Reed University of Arkansas for Medical Sciences 1 shared publication Alyson T. McKinnon University of Arkansas for Medical Sciences 1 shared publication

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