Stefanie Kennon‐McGill

Researcher

UAMS

Also affiliated: Washington University in St. Louis (2017); University of Arkansas Medical Center (2019); Sparrow Hospital (2024); Faculty of Public Health (2019); University of Kansas Medical Center (2015–2016); Arkansas Department of Health (2021)

Faculty Researcher

13 h-index 32 pubs 856 cited

Research Areas

Biomedical Subjects

Links

ORCID Research Group

OverviewAI-generated summary

Stefanie Kennon‐McGill's research focuses on understanding the mechanisms of drug-induced liver injury, particularly related to acetaminophen. Her work investigates how metabolic processes, such as pyruvate and alanine metabolism, contribute to antioxidant capacity and resistance to oxidative stress in the liver. She has explored the role of specific signaling pathways, like interleukin-6, and inter-organ crosstalk in mitigating liver damage. Her studies have involved animal models (mice) and human cell-based systems, including a quad liver-on-chip model, to bridge the gap between preclinical and human toxicology and pharmacology.

Beyond drug-induced liver injury, Kennon‐McGill's research extends to maternal health, examining factors associated with the use of substances like cannabidiol during pregnancy and perceptions surrounding marijuana use in pregnancy. Her publications have been supported by collaborations with researchers at the University of Arkansas for Medical Sciences and the University of Arkansas at Fayetteville. She has published 32 papers with 835 citations and an h-index of 13.

Metrics

h-index: 13
Publications: 32
Citations: 856

Selected Publications

Receipt of reproductive safety data among pregnant marijuana users and nonusers (2026)

Archives of Women s Mental Health DOI OpenAlex
NAPQI is absent in the mouse brain after sub-hepatotoxic and hepatotoxic doses of acetaminophen (2025)

Toxicological Sciences 5 citations DOI OpenAlex
Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract (2024)

Drug and Chemical Toxicology 3 citations DOI OpenAlex
Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult (2023)

Molecular Metabolism 28 citations DOI OpenAlex
Factors associated with ever using cannabidiol in a cohort of younger pregnant people (2023)

Neurotoxicology and Teratology 12 citations DOI OpenAlex
Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways (2022)

Toxicological Sciences 38 citations DOI OpenAlex
Proteomics Indicates Lactate Dehydrogenase is Prognostic in Acetaminophen-induced Acute Liver Failure Patients and Reveals a Role for LKB1-AMPK Signaling (2021)

medRxiv DOI OpenAlex
Short‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis (2021)

Hepatology Communications 24 citations DOI OpenAlex
Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk (2021)

Acta Pharmaceutica Sinica B 22 citations DOI OpenAlex
Ototoxicity and Drug Transport in the Cochlea (2021)

DOI OpenAlex
55715 Quantification of Neonatal THC Exposure Following Prenatal Marijuana Use (2021)

Journal of Clinical and Translational Science DOI OpenAlex
Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk (2020)

bioRxiv (Cold Spring Harbor Laboratory) 2 citations DOI OpenAlex
Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration (2020)

International Journal of Molecular Sciences 14 citations DOI OpenAlex
Pre-treatment twice with liposomal clodronate protects against acetaminophen hepatotoxicity through a pre-conditioning effect (2020)

Liver Research 7 citations DOI OpenAlex
Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration (2019)

Molecules 36 citations DOI OpenAlex