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Confirmed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-08
A
Alexei G. Basnakian
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Federal Grant PI
High Impact
Professor
Also affiliated: Tufts University (1997); Boston Biomedical Research Institute (1989); United States Food and Drug Administration (1994–1996); University of Debrecen (2005); University of Arkansas Medical Center (2002–2024); Ege University (2007); Central Arkansas Veterans Healthcare System (2001–2025); Jean Mayer Human Nutrition Research Center on Aging (1997); Institute of Biomedical Chemistry (1991); John L. McClellan Memorial Veterans Hospital (2006–2024); Ege Üniversitesi Tıp Fakültesi Hastanesi (2007)
37 h-index
144 pubs
4,508 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Alexei G. Basnakian's research program investigates mechanisms of cellular injury and death, with a particular focus on kidney disease and cancer. His work has explored the role of DNA damage, apoptosis, and metabolic imbalances in the development of these conditions. Basnakian has studied the effects of nutrient deficiencies, such as folate deficiency, on DNA integrity and mutagenesis in cell culture models and animal studies. He has also investigated the contribution of modified lipoproteins, like carbamylated low-density lipoprotein, to the pathogenesis of atherosclerosis, especially in the context of chronic kidney disease.
His laboratory employs various techniques, including the TUNEL assay for evaluating kidney injury. Basnakian has received federal funding from the NIH for his research, including a BLRD Research Career Scientist Award, and has served as PI on grants examining nuclease mechanisms in acute kidney injury. He has a publication record of 142 papers with over 4,100 citations and an h-index of 36, reflecting his significant contributions to the field. Basnakian actively collaborates with researchers at the University of Arkansas for Medical Sciences, including Martin J. Cannon, Steven R. Post, Camila Simões, and Mulu Z. Tesfay.
Metrics
- h-index: 37
- Publications: 144
- Citations: 4,508
Positions
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Professor publications 1996–2026University of Arkansas for Medical Sciences Department of Pharmacology and Toxicology Institutional directory
Selected Publications
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Dual Targeting of EZH2 and LSD1 Suppresses Hepatocellular Carcinoma via Disruption of Sonic Hedgehog Signaling (2026)
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Abstract 4378: Live attenuated MMR vaccines modulate tumor immune cell infiltration and synergize with standard of care to prolong survival in preclinical HCC models (2026)
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An enhancement of extrachromosomal circular DNA enrichment and amplification to address the extremely low overlap between replicates (2026)
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Design, Synthesis, and Development of 4-[2-[3,5-Bis(trifluoromethyl)anilino]thiazolo-4-yl]phenol as a Dual Inhibitor of Fatty Acid Biosynthesis (FASII) to Clear MRSA Infection (2026)
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Pancreatic tumor microenvironment reprogramming via alloantigen-expressing virotherapy elicits tumor rejection and improves immunotherapy response (2026)
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Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models (2025)
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Abstract B022: Reprogramming Apoptotic Resistance in PDAC Through Synthetic Oncolytic Immunotherapy (2025)
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An Enhancement of Extrachromosomal Circular DNA Enrichment and Amplification to Address the Extremely Low Overlap Between Replicates (2025)
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Abstract 945: Live attenuated MMR vaccines modulate tumor immune cell infiltration and synergize with standard of care to prolong survival in preclinical HCC models (2025)
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Abstract 947: Engineering a synthetic oncolytic virus to overcome apoptotic resistance and induce immunogenic cell death in pancreatic ductal adenocarcinoma (2025)
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Correction: Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors (2025)
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The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury (2025)
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Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors (2024)
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Generation of BT-Amide, a Bone-Targeted Pyk2 Inhibitor, Effective via Oral Administration, for the Prevention of Glucocorticoid-Induced Bone Loss (2024)
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Enhancing Neoadjuvant Virotherapy’s Effectiveness by Targeting Stroma to Improve Resectability in Pancreatic Cancer (2024)
Federal Grants 2
VA
Contact PI
Oct 2022 - Sep 2027
VA
Contact PI
Oct 2014 - Aug 2028
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- The role of endonuclease G in nuclear apoptosis of atrophying skeletal muscle NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases via University of Kentucky Research Foundation
- Endonuclease-targeted radioprotection NIH/Nat. Inst. of Allergy & Infectious Diseases via Duke University
- Endonuclease dificiency in breast cancer progression NIH
- Novel DNA damage-based technology for evaluation of graphene toxicity in vitro and in vivo U.S. Food and Drug Administration via Arkansas Research Alliance
- A nanotherapeutic approach to combat staphylococcal biofilm-associated infection NIH
- CRIC Ancillary Study: Carbamylated low-density lipoprotein and cardiovascular eve NIH
- LDL isoforms in kidney-related atherosclerosisv NIH
- Using Advanced Functional Nanomaterials to Fight Cancer. U.S. Army Medical Research & Materiel Command via University of Arkansas at Little Rock
- DNase-Targeted Mitigation of Acute Kidney Injury Due to Rhabdomyolysis NIH
- Premortem enzymatic DNA damage in kidney injury NIH
- NOVEL SERUM AND URINARY BIOMARKERS OF DIABETIC KIDNEY DISEASE NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases via Mount Sinai School of Medicine
- Novel endonuclease-targeted approaches to nephroprotection NIH
- Center for Studies of Host Response to Cancer Therapy NIH
- Environmental risk assessment of carbon nanomaterials used as plant growth regulators US Department of Agriculture via University of Arkansas at Little Rock
- In vivo, noninvasive, ultrasensitive photoacoustic detection of early breast cancer metastasis in bone US Department of the Army
Collaboration Network
Top Collaborators
Eugene O. Apostolov
28 shared publications
In database
- Carbamylated low-density lipoprotein induces death ofendothelial cells: A link to atherosclerosis in patients with kidney disease
- Chronic Uremia Stimulates LDL Carbamylation and Atherosclerosis
- Melatonin increases survival of HaCaT keratinocytes by suppressing UV‐induced apoptosis
- Cisplatin Nephrotoxicity Is Mediated by Deoxyribonuclease I
- Quantification of Carbamylated LDL in Human Sera by a New Sandwich ELISA
Showing 5 of 28 shared publications
Sudhir V. Shah
28 shared publications
In database
- Carbamylated low-density lipoprotein induces death ofendothelial cells: A link to atherosclerosis in patients with kidney disease
- Apoptotic pathways in ischemic acute renal failure
- Chronic Uremia Stimulates LDL Carbamylation and Atherosclerosis
- Cisplatin Nephrotoxicity Is Mediated by Deoxyribonuclease I
- Apoptotic Pathways of Oxidative Damage to Renal Tubular Epithelial Cells
Showing 5 of 28 shared publications
Alena V. Savenka
University of Arkansas for Medical Sciences
23 shared publications
In database
- TUNEL Assay: A Powerful Tool for Kidney Injury Evaluation
- Chronic Uremia Stimulates LDL Carbamylation and Atherosclerosis
- Carbamylated-Oxidized LDL: Proatherosclerotic Effects on Endothelial Cells and Macrophages
- Mechanism of graphene‐induced cytotoxicity: Role of endonucleases
- 4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents
Showing 5 of 23 shared publications
Xiaoying Wang
University of Arkansas for Medical Sciences (US)
12 shared publications
- Regulation of Apoptotic Endonucleases by EndoG
- Epigenetic alterations induced by ambient particulate matter in mouse macrophages
- Sensitivity of human prostate cancer cells to chemotherapeutic drugs depends on EndoG expression regulated by promoter methylation
- Uptake of Foreign Nucleic Acids in Kidney Tubular Epithelial Cells Deficient in Proapoptotic Endonucleases
- Novel Cytoprotective Inhibitors for Apoptotic Endonuclease G
Showing 5 of 12 shared publications
Tariq Fahmi
University of Arkansas for Medical Sciences
11 shared publications
In database
- Circulating tumor cell identification by functionalized silver-gold nanorods with multicolor, super-enhanced SERS and photothermal resonances
- Regulation of Apoptotic Endonucleases by EndoG
- Mechanism of graphene‐induced cytotoxicity: Role of endonucleases
- Photoacoustic flow cytometry for nanomaterial research
- DNase I Induces Other Endonucleases in Kidney Tubular Epithelial Cells by Its DNA-Degrading Activity
Showing 5 of 11 shared publications
Todd Fite
Central Arkansas Veterans Healthcare System (US)
11 shared publications
- Synthesis of Hydrazone Derivatives of 4-[4-Formyl-3-(2-oxochromen-3-yl)pyrazol-1-yl]benzoic acid as Potent Growth Inhibitors of Antibiotic-resistant Staphylococcus aureus and Acinetobacter baumannii
- Comprehensive Risk Assessment of Carbon Nanotubes Used for Agricultural Applications
- Synthesis of 4,4′-(4-Formyl-1H-pyrazole-1,3-diyl)dibenzoic Acid Derivatives as Narrow Spectrum Antibiotics for the Potential Treatment of Acinetobacter Baumannii Infections
- Protective effect of zinc-N-acetylcysteine on the rat kidney during cold storage
- Light-Powered Nanoconverters Cytotoxic to Breast Cancer Cells
Showing 5 of 11 shared publications
Martin J. Cannon
University of Arkansas for Medical Sciences
9 shared publications
In database
- Characterization of Morreton virus as an oncolytic virotherapy platform for liver cancers
- Repurposing live attenuated trivalent MMR vaccine as cost-effective cancer immunotherapy
- Enhancing Neoadjuvant Virotherapy’s Effectiveness by Targeting Stroma to Improve Resectability in Pancreatic Cancer
- Abstract 5004: Oncolytic Jurona-driven systemic and intratumoral immunotherapy combined with immune checkpoint blockade boost immune response and survival in hepatocellular carcinoma models
- Abstract 947: Engineering a synthetic oncolytic virus to overcome apoptotic resistance and induce immunogenic cell death in pancreatic ductal adenocarcinoma
Showing 5 of 9 shared publications
Mulu Z. Tesfay
Winthrop Rockefeller Foundation
9 shared publications
In database
- Repurposing live attenuated trivalent MMR vaccine as cost-effective cancer immunotherapy
- Enhancing Neoadjuvant Virotherapy’s Effectiveness by Targeting Stroma to Improve Resectability in Pancreatic Cancer
- Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models
- Abstract 5004: Oncolytic Jurona-driven systemic and intratumoral immunotherapy combined with immune checkpoint blockade boost immune response and survival in hepatocellular carcinoma models
- Abstract 947: Engineering a synthetic oncolytic virus to overcome apoptotic resistance and induce immunogenic cell death in pancreatic ductal adenocarcinoma
Showing 5 of 9 shared publications
Khandoker Usran Ferdous
University of Arkansas for Medical Sciences
9 shared publications
In database
- Repurposing live attenuated trivalent MMR vaccine as cost-effective cancer immunotherapy
- Enhancing Neoadjuvant Virotherapy’s Effectiveness by Targeting Stroma to Improve Resectability in Pancreatic Cancer
- Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models
- Abstract 5004: Oncolytic Jurona-driven systemic and intratumoral immunotherapy combined with immune checkpoint blockade boost immune response and survival in hepatocellular carcinoma models
- Abstract 947: Engineering a synthetic oncolytic virus to overcome apoptotic resistance and induce immunogenic cell death in pancreatic ductal adenocarcinoma
Showing 5 of 9 shared publications
Gáspár Bánfalvi
University of Debrecen (HU)
8 shared publications
- Common Pathway of Chromosome Condensation in Mammalian Cells
- Cell culture density dependent toxicity and chromatin changes upon cadmium treatment in murine pre-B-cells
- Gamma irradiation-induced apoptosis in murine pre-B cells prevents the condensation of fibrillar chromatin in early S phase
- Condensation of Interphase Chromatin in Nuclei of Synchronized Chinese Hamster Ovary (CHO-K1) Cells
- Uptake of Foreign Nucleic Acids in Kidney Tubular Epithelial Cells Deficient in Proapoptotic Endonucleases
Showing 5 of 8 shared publications
Randal S. Shelton
University of Arkansas for Medical Sciences
8 shared publications
In database
- Comprehensive Risk Assessment of Carbon Nanotubes Used for Agricultural Applications
- Enhancing Neoadjuvant Virotherapy’s Effectiveness by Targeting Stroma to Improve Resectability in Pancreatic Cancer
- Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models
- Abstract 5004: Oncolytic Jurona-driven systemic and intratumoral immunotherapy combined with immune checkpoint blockade boost immune response and survival in hepatocellular carcinoma models
- Endonuclease G (EndoG) Inhibits DNase I-Mediated Apoptosis and DNA Repair in Kidney Tubular Epithelial Cells During Cisplatin Injury
Showing 5 of 8 shared publications
Steven R. Post
Winthrop Rockefeller Foundation
8 shared publications
In database
- Characterization of Morreton virus as an oncolytic virotherapy platform for liver cancers
- Repurposing live attenuated trivalent MMR vaccine as cost-effective cancer immunotherapy
- Enhancing Neoadjuvant Virotherapy’s Effectiveness by Targeting Stroma to Improve Resectability in Pancreatic Cancer
- Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models
- Abstract 5004: Oncolytic Jurona-driven systemic and intratumoral immunotherapy combined with immune checkpoint blockade boost immune response and survival in hepatocellular carcinoma models
Showing 5 of 8 shared publications
Aleksandra Cios
University of Maryland, Baltimore (US)
8 shared publications
- Enhancing Neoadjuvant Virotherapy’s Effectiveness by Targeting Stroma to Improve Resectability in Pancreatic Cancer
- Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models
- Abstract 5004: Oncolytic Jurona-driven systemic and intratumoral immunotherapy combined with immune checkpoint blockade boost immune response and survival in hepatocellular carcinoma models
- Abstract 947: Engineering a synthetic oncolytic virus to overcome apoptotic resistance and induce immunogenic cell death in pancreatic ductal adenocarcinoma
- Abstract 945: Live attenuated MMR vaccines modulate tumor immune cell infiltration and synergize with standard of care to prolong survival in preclinical HCC models
Showing 5 of 8 shared publications
Xiaoyan Yin
University of Arkansas for Medical Sciences (US)
7 shared publications
- Ceramide synthase is essential for endonuclease-mediated death of renal tubular epithelial cells induced by hypoxia-reoxygenation
- Endonuclease G promotes cell death of non-invasive human breast cancer cells
- Sensitivity of human prostate cancer cells to chemotherapeutic drugs depends on EndoG expression regulated by promoter methylation
- Uptake of Foreign Nucleic Acids in Kidney Tubular Epithelial Cells Deficient in Proapoptotic Endonucleases
- Apoptotic/Recombinogenic Endonuclease G is Regulated by Promoter Methylation and Histone Acetylation.
Showing 5 of 7 shared publications
Isabelle R. Miousse
University of Arkansas for Medical Sciences
7 shared publications
In database
- Epigenetic alterations induced by ambient particulate matter in mouse macrophages
- Effects of Gamma-Tocotrienol on Intestinal Injury in a GI-Specific Acute Radiation Syndrome Model in Nonhuman Primate
- Effects of Gamma-Tocotrienol on Partial-Body Irradiation-Induced Intestinal Injury in a Nonhuman Primate Model
- Enhancing Neoadjuvant Virotherapy’s Effectiveness by Targeting Stroma to Improve Resectability in Pancreatic Cancer
- Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models
Showing 5 of 7 shared publications
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