Sayem Miah
Assistant Professor
Also affiliated: Linköping University (2009–2012); Stowers Institute for Medical Research (2016–2021); Kansas City Kansas Community College (2016); University of Saskatchewan (2012–2019); University of Kansas Medical Center (2017); Winthrop Rockefeller Foundation (2021–2026)
Faculty Researcher
Biochemistry & Molecular Biology, College of Medicine
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Sayem Miah's research focuses on understanding the molecular mechanisms underlying cancer, particularly breast cancer. His work investigates how gene expression is regulated during tumorigenesis and metastasis, with an emphasis on signaling pathways and chromatin remodeling. Miah has explored the role of specific proteins and complexes, such as BRMS1 and the Sin3/HDAC complex, in cancer progression and has identified potential therapeutic targets.
His publications include studies on multi-omics data integration to identify regulatory features of triple-negative breast cancer, the impact of oncogenic signaling on chromatin, and the perturbation of protein interactomes to understand metastasis. Miah also investigates novel drug candidates, such as pyrazolo[3,4-d]pyrimidine derivatives as BRK/PTK6 inhibitors, and the effects of existing drugs like desloratadine on cancer cell apoptosis. His research is supported by his h-index of 15 and 34 total publications, with 516 citations.
Metrics
- h-index: 15
- Publications: 34
- Citations: 524
Selected Publications
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Loss of FAM60A disrupts Sin3/HDAC control of the Hippo signaling and promotes oncogenic YAP1 activation (2026)
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Discovery of novel 1H-pyrazolo[3,4-d]pyrimidine derivatives as BRK/PTK6 inhibitors (2025)
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Discovery of Novel 1h-Pyrazolo[3,4-D]Pyrimidine Derivatives as Brk/Ptk6 Inhibitors (2025)
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Beyond the Sin3/HDAC Complex: FAM60A emerges as a regulator of RNA Splicing (2024)
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Oncogenic signaling-mediated regulation of chromatin during tumorigenesis (2023)
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443 Team Science (2023)
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Targeting TGF-β: Triumphs and Challenges (2022)
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Perturbation of BRMS1 interactome reveals pathways that impact metastasis (2021)
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Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer (2021)
Grants & Funding
As listed on this researcher's institutional profile.
- Center for Molecular Interactions in Cancer (CMIC) NIH Co-Investigator
- TRI KL2 Scholars award - Miah UAMS Internal Research Awards Principal Investigator
- TRI KL2 Scholars award - Ashby UAMS College of Medicine Principal Investigator
- AWD-037194: 4721 - Non-Receptor Protein Tyrosine Kinases (nRTKs), GR037194 ABI Non-Receptor Protein Tyrosine Kinases (nRTKs) UAMS ACHRI Flow Through Principal Investigator
Collaboration Network
Top Collaborators
- Targeting TGF-β: Triumphs and Challenges
- 443 Team Science
- Discovery of Novel 1h-Pyrazolo[3,4-D]Pyrimidine Derivatives as Brk/Ptk6 Inhibitors
- Targeting TGF-β: Triumphs and Challenges
- 443 Team Science
- Discovery of Novel 1h-Pyrazolo[3,4-D]Pyrimidine Derivatives as Brk/Ptk6 Inhibitors
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- Beyond the Sin3/HDAC Complex: FAM60A emerges as a regulator of RNA Splicing
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- Beyond the Sin3/HDAC Complex: FAM60A emerges as a regulator of RNA Splicing
- Perturbation of BRMS1 interactome reveals pathways that impact metastasis
- Beyond the Sin3/HDAC Complex: FAM60A emerges as a regulator of RNA Splicing
- Perturbation of BRMS1 interactome reveals pathways that impact metastasis
- Beyond the Sin3/HDAC Complex: FAM60A emerges as a regulator of RNA Splicing
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
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