Thomas M. Badger
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Also affiliated: Boston University (1980–1981); Tulane University (1985–1991); Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (2008); University of Iowa (1988); Brigham and Women's Hospital (1987); National Institutes of Health (1991); Arkansas Children's Hospital (1991–2016); Salk Institute for Biological Studies (1988); Amgen (United States) (2002–2005); United States Department of Agriculture (2010–2011); Harvard University (1980–1987); University of Georgia (1986); University of Massachusetts Chan Medical School (1985); Washington University in St. Louis (1977–1978); Hubei University of Chinese Medicine (2007); Anhui University of Traditional Chinese Medicine (2008); University of Michigan (1985); University of Arkansas Medical Center (1990–2019); Tulane Medical Center (1984); University of Florida Health (1991); Karolinska Institutet (2008); University of Florida (1983–1991); Massachusetts General Hospital (1980–2008); Michigan Medicine (1985); Maine Medical Center (1988); National Cancer Institute (1991); Arkansas Children's Nutrition Center (1999–2023); Pediatrics and Genetics (2011); Arkansas Children's Research Institute (1994–2023); University of Manitoba (1983); University of Virginia (1985); University of Colorado Anschutz (2016); California State University, Long Beach (2012); Massachusetts Institute of Technology (1983); University of Missouri (1972–1978); Icahn School of Medicine at Mount Sinai (1985)
Formerly Arkansas Professor and Division Chief, UAMS through 2015.
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Thomas M. Badger's research focuses on diet, metabolism, and disease mechanisms, particularly concerning the long-term effects of maternal nutrition on offspring health. His work has investigated the impact of dietary components such as soy and whey proteins on colon tumorigenesis in rats and the metabolic phenotypes of isoflavones in various species, including humans. Badger has also examined the influence of maternal obesity on the placental environment and its potential to program obesity in offspring. His research group has explored the effects of lipogenic diets on metabolic rates and hepatic gene expression in mice.
With an h-index of 72 and over 422 publications, Badger is recognized as a highly cited researcher. His collaborations include work with researchers from the National Center for Toxicological Research, such as Kelly E. Mercer and Rebecca Wynne, as well as colleagues from the University of Arkansas for Medical Sciences, including Xiawei Ou and Xiaoxu Na. His recent activity indicates ongoing contributions to the field, with publications extending to 2023.
Metrics
- h-index: 72
- Publications: 422
- Citations: 15,745
Positions
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Professor and Division Chief 1986–2015University of Arkansas for Medical Sciences Pediatrics ORCID
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Professor 1976–1986Harvard Medical School Ob/Gyn ORCID
Selected Publications
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Associations between mother’s depressive symptoms during pregnancy and newborn’s brain functional connectivity (2023)
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A longitudinal observational study of skeletal development between ages 3 mo and 6 y in children fed human milk, milk formula, or soy formula (2023)
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Soy Formula Is Not Estrogenic and Does Not Result in Reproductive Toxicity in Male Piglets: Results from a Controlled Feeding Study (2022)
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Associations Between White Matter Microstructures and Cognitive Functioning in 8-Year-Old Children: A Track-Weighted Imaging Study (2022)
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Track-weighted imaging analysis of white matter microstructures in healthy children: Sex and hemispheric differences (2022)
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Associations between Cortical Asymmetry and Domain Specific Cognitive Functions in Healthy Children (2021)
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Correlations between sleep disturbance and brain cortical morphometry in healthy children (2021)
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Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula (2020)
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Diffusion Tensor MRI of White Matter of Healthy Full-term Newborns: Relationship to Neurodevelopmental Outcomes (2019)
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Maternal Adiposity Influences Neonatal Brain Functional Connectivity (2019)
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Concentrations of Purine Metabolites Are Elevated in Fluids from Adults and Infants and in Livers from Mice Fed Diets Depleted of Bovine Milk Exosomes and their RNA Cargos (2018)
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Cesarean Delivery Impacts Infant Brain Development (2018)
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Human Breast-Milk Feeding Enhances the Humoral and Cell-Mediated Immune Response in Neonatal Piglets (2018)
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Gestational Age at Birth and Brain White Matter Development in Term-Born Infants and Children (2017)
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Maternal obesity and gestational weight gain are modestly associated with umbilical cord DNA methylation (2017)
Grants & Funding
As listed on this researcher's institutional profile.
- Long Term Health Consequences (034504) UAMS ACHRI Flow Through
- Alcohol: Direct and Indirect Effects in Drug Metabolism NIH
- COCAINE--NEUROENDOCRINE CONTROL &SEX STEROID METABOLISM NIH
- NUTRITION AND THE HYPOTHALAMIC-PITUITARY-GONADAL AXIS NIH
- ALCOHOL, PULSATILE HORMONES AND MOLECULAR MECHANISMS NIH
- CARBOHYDRATE-ETHANOL INTERACTIONS--DIET DELIVERY SYSTEMS NIH
Collaboration Network
Top Collaborators
- Metabolic Phenotype of Isoflavones Differ among Female Rats, Pigs, Monkeys, and Women
- Maternal Obesity Enhances White Adipose Tissue Differentiation and Alters Genome-Scale DNA Methylation in Male Rat Offspring
- Reproductive Toxicity and Growth Effects in Rats Exposed to Lead at Different Periods during Development
- Non-isoflavone Phytochemicals in Soy and Their Health Effects
- Dietary Soy Protein Isolate Attenuates Metabolic Syndrome in Rats via Effects on PPAR, LXR, and SREBP Signaling
Showing 5 of 76 shared publications
- Maternal obesity is associated with a lipotoxic placental environment
- Maternal Obesity Enhances White Adipose Tissue Differentiation and Alters Genome-Scale DNA Methylation in Male Rat Offspring
- Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
- Maternal Obesity Promotes a Proinflammatory Signature in Rat Uterus and Blastocyst
- Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula
Showing 5 of 45 shared publications
- Maternal obesity is associated with a lipotoxic placental environment
- Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula
- Brain gray and white matter differences in healthy normal weight and obese children
- The health implications of soy infant formula
- Developmental Status of 1-Year-Old Infants Fed Breast Milk, Cow’s Milk Formula, or Soy Formula
Showing 5 of 28 shared publications
- Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
- Maternal Obesity Promotes a Proinflammatory Signature in Rat Uterus and Blastocyst
- Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats
- The health implications of soy infant formula
- Feeding Blueberry Diets in Early Life Prevent Senescence of Osteoblasts and Bone Loss in Ovariectomized Adult Female Rats
Showing 5 of 22 shared publications
- Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
- Maternal Obesity Promotes a Proinflammatory Signature in Rat Uterus and Blastocyst
- Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats
- High Fat Diet and In Utero Exposure to Maternal Obesity Disrupts Circadian Rhythm and Leads to Metabolic Programming of Liver in Rat Offspring
- Maternal Obesity during Gestation Impairs Fatty Acid Oxidation and Mitochondrial SIRT3 Expression in Rat Offspring at Weaning
Showing 5 of 21 shared publications
- Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
- Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats
- Feeding Blueberry Diets in Early Life Prevent Senescence of Osteoblasts and Bone Loss in Ovariectomized Adult Female Rats
- Ethanol Impairs Estrogen Receptor Signaling Resulting in Accelerated Activation of Senescence Pathways, Whereas Estradiol Attenuates the Effects of Ethanol in Osteoblasts
- Inhibition of fetal bone development through epigenetic down‐regulation of HoxA10 in obese rats fed high‐fat diet
Showing 5 of 16 shared publications
- Brain gray and white matter differences in healthy normal weight and obese children
- Developmental Status of 1-Year-Old Infants Fed Breast Milk, Cow’s Milk Formula, or Soy Formula
- Longitudinal body composition of children born to mothers with normal weight, overweight, and obesity
- Obesity Modulates Inflammation and Lipid Metabolism Oocyte Gene Expression: A Single-Cell Transcriptome Perspective
- Medium chain triglycerides dose-dependently prevent liver pathology in a rat model of non-alcoholic fatty liver disease
Showing 5 of 14 shared publications
- Induction of Cytochrome P450 2E1 during Chronic Ethanol Exposure Occurs via Transcription of the Cyp 2E1 Gene When Blood Alcohol Concentrations Are High
- Effects of chronic ethanol on growth hormone secretion and hepatic cytochrome P450 isozymes of the rat.
- Rat model of distraction osteogenesis
- Estradiol Protects against Ethanol-Induced Bone Loss by Inhibiting Up-Regulation of Receptor Activator of Nuclear Factor-κB Ligand in Osteoblasts
- Restoration of regenerative osteoblastogenesis in aged mice: Modulation of TNF
Showing 5 of 14 shared publications
- Brain gray and white matter differences in healthy normal weight and obese children
- The health implications of soy infant formula
- Developmental Status of 1-Year-Old Infants Fed Breast Milk, Cow’s Milk Formula, or Soy Formula
- A longitudinal study of differences in electroencephalographic activity among breastfed, milk formula-fed, and soy formula-fed infants during the first year of life
- Early Infant Diet and the Omega 3 Fatty Acid DHA: Effects on Resting Cardiovascular Activity and Behavioral Development During the First Half-Year of Life
Showing 5 of 12 shared publications
- Brain gray and white matter differences in healthy normal weight and obese children
- Maternal adiposity negatively influences infant brain white matter development
- Differences in brain functional connectivity at resting state in neonates born to healthy obese or normal-weight mothers
- Diffusion Tensor MRI of White Matter of Healthy Full-term Newborns: Relationship to Neurodevelopmental Outcomes
- Cesarean Delivery Impacts Infant Brain Development
Showing 5 of 12 shared publications
- The Health Consequences of Early Soy Consumption
- Dietary Saturated Fat Reduces Alcoholic Hepatotoxicity in Rats by Altering Fatty Acid Metabolism and Membrane Composition
- Soy protein isolate consumption protects against azoxymethane-induced colon tumors in male rats
- Episodic excretion of ethanol during chronic intragastric ethanol infusion in the male rat: continuous vs. cyclic ethanol and nutrient infusions.
- Soy and Whey Proteins Downregulate DMBA-Induced Liver and Mammary Gland CYP1 Expression in Female Rats
Showing 5 of 10 shared publications
- Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula
- Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon
- Formula diet alters small intestine morphology, microbial abundance and reduces VE-cadherin and IL-10 expression in neonatal porcine model
- Early Postnatal Diets Affect the Bioregional Small Intestine Microbiome and Ileal Metabolome in Neonatal Pigs
- Vitamin D Supplementation Protects against Bone Loss Associated with Chronic Alcohol Administration in Female Mice
Showing 5 of 10 shared publications
- The açaí flavonoid velutin is a potent anti-inflammatory agent: blockade of LPS-mediated TNF-α and IL-6 production through inhibiting NF-κB activation and MAPK pathway
- Non-isoflavone Phytochemicals in Soy and Their Health Effects
- Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
- Blueberries reduce pro‐inflammatory cytokine TNF‐α and IL‐6 production in mouse macrophages by inhibiting NF‐κB activation and the MAPK pathway
- Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats
Showing 5 of 10 shared publications
- Maternal obesity is associated with a lipotoxic placental environment
- Maternal Obesity Enhances White Adipose Tissue Differentiation and Alters Genome-Scale DNA Methylation in Male Rat Offspring
- High Fat Diet and In Utero Exposure to Maternal Obesity Disrupts Circadian Rhythm and Leads to Metabolic Programming of Liver in Rat Offspring
- A comprehensive analysis of the human placenta transcriptome
- Maternal pregravid obesity changes gene expression profiles toward greater inflammation and reduced insulin sensitivity in umbilical cord
Showing 5 of 9 shared publications
- Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis.
- Chronic Ethanol Intake Impairs Insulin Signaling in Rats by Disrupting Akt Association with the Cell Membrane
- Soy Protein Isolate and Protection Against Cancer
- Physiologic and Genomic Analyses of Nutrition-Ethanol Interactions During Gestation: Implications for Fetal Ethanol Toxicity
- Dose-Dependent Effects of Alcohol on Insulin Signaling: Partial Explanation for Biphasic Alcohol Impact on Human Health
Showing 5 of 9 shared publications
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