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Presence
Current · Arkansas
Last published
2025
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OpenAlex · ORCID
Refreshed
2026-08-15
V
Volodymyr Tryndyak
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Researcher
Also affiliated: University of Lethbridge (2008); Roswell Park Comprehensive Cancer Center (2008); United States Food and Drug Administration (2009–2023); National Academy of Sciences of Ukraine (2005); Biochemical Society (2012–2017); R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology (2005–2013); National Cancer Institute (2008); Centre international de recherche sur le cancer (2023); University of Tennessee at Knoxville (2006)
Faculty Researcher
44 h-index
158 pubs
6,730 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Volodymyr Tryndyak's research investigates the molecular mechanisms underlying toxicity and disease, with a focus on epigenetic alterations and gene expression changes in response to environmental exposures and dietary factors. His work has explored the impact of specific diets, such as high-fat and high-sucrose, on the liver, examining associated DNA methylation and gene expression changes in genetically diverse mouse models. Tryndyak also studies the epigenetic effects of dietary components like methionine and investigates the genotoxicity of various compounds, including perfluorinated chemicals and herbal extracts, in human cells and animal models.
Further research by Tryndyak has examined the toxicokinetics of specific chemical metabolites in pregnant and non-pregnant rats and the potential mechanisms of apoptosis induced by inorganic arsenic in zebrafish. His work also includes analyzing the dynamics of SARS-CoV-2 genomes and identifying variants in wastewater, contributing to public health surveillance. With an h-index of 44 and over 6,600 citations from 158 publications, Tryndyak is recognized as a highly cited researcher. He has a history of collaboration with researchers at the National Center for Toxicological Research, including Igor P. Pogribny and Frederick A. Beland.
Metrics
- h-index: 44
- Publications: 158
- Citations: 6,730
Selected Publications
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Mediation analysis of the molecular phenotypes in a severe MASH-like liver injury mouse model (2025)
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Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice (2025)
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Wastewater dataset on the SARS-CoV-2 sublineages circulating in Central Arkansas, USA, post-COVID-19 pandemic (2025)
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A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice (2024)
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Cellular and molecular alterations in a human hepatocellular in vitro model of nonalcoholic fatty liver disease development and stratification (2023)
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Evaluating the toxicokinetics of some metabolites of a C6 polyfluorinated compound, 6:2 fluorotelomer alcohol in pregnant and nonpregnant rats after oral exposure to the parent compound (2023)
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Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish (2023)
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Abstract 6017: Exposure-related DNA methylation and gene expression changes in mammary glands of Sprague Dawley rats treated with lorcaserin (2023)
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Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice (2023)
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Temporal dynamics of SARS-CoV-2 genome and detection of variants of concern in wastewater influent from two metropolitan areas in Arkansas (2022)
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Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice (2022)
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Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet (2022)
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Epigenetic changes induced in mice liver by methionine-supplemented and methionine-deficient diets (2022)
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Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells (2021)
Collaboration Network
Top Collaborators
Igor P. Pogribny
National Center for Toxicological Research
9 shared publications
In database
- Epigenetic changes induced in mice liver by methionine-supplemented and methionine-deficient diets
- Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
Showing 5 of 9 shared publications
Frederick A. Beland
National Center for Toxicological Research
9 shared publications
In database
- Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish
- Evaluating the toxicokinetics of some metabolites of a C6 polyfluorinated compound, 6:2 fluorotelomer alcohol in pregnant and nonpregnant rats after oral exposure to the parent compound
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
Showing 5 of 9 shared publications
Rose Willett
National Center for Toxicological Research
8 shared publications
In database
- Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
- Cellular and molecular alterations in a human hepatocellular in vitro model of nonalcoholic fatty liver disease development and stratification
Showing 5 of 8 shared publications
Ivan Rusyn
Texas A&M University (US)
6 shared publications
- Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
- Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice
Showing 5 of 6 shared publications
Mark Avigan
United States Food and Drug Administration (US)
5 shared publications
- Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
- Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice
Suresh K. Nagumalli
National Center for Toxicological Research
3 shared publications
In database
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
Camila Silva
3 shared publications
In database
- Temporal dynamics of SARS-CoV-2 genome and detection of variants of concern in wastewater influent from two metropolitan areas in Arkansas
- Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish
- Wastewater dataset on the SARS-CoV-2 sublineages circulating in Central Arkansas, USA, post-COVID-19 pandemic
Aline de Conti
National Center for Toxicological Research (US)
2 shared publications
- Epigenetic changes induced in mice liver by methionine-supplemented and methionine-deficient diets
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
Gonçalo Gamboa da Costa
National Center for Toxicological Research
2 shared publications
In database
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
Luísa Camacho
National Center for Toxicological Research
2 shared publications
In database
- Temporal dynamics of SARS-CoV-2 genome and detection of variants of concern in wastewater influent from two metropolitan areas in Arkansas
- Wastewater dataset on the SARS-CoV-2 sublineages circulating in Central Arkansas, USA, post-COVID-19 pandemic
Lisa Mullis
National Center for Toxicological Research
2 shared publications
In database
- Temporal dynamics of SARS-CoV-2 genome and detection of variants of concern in wastewater influent from two metropolitan areas in Arkansas
- Wastewater dataset on the SARS-CoV-2 sublineages circulating in Central Arkansas, USA, post-COVID-19 pandemic
Marli S.P. Azevedo
National Center for Toxicological Research
2 shared publications
In database
- Temporal dynamics of SARS-CoV-2 genome and detection of variants of concern in wastewater influent from two metropolitan areas in Arkansas
- Wastewater dataset on the SARS-CoV-2 sublineages circulating in Central Arkansas, USA, post-COVID-19 pandemic
Tetyana Kudlyk
National Center for Toxicological Research
2 shared publications
In database
- Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish
- Wastewater dataset on the SARS-CoV-2 sublineages circulating in Central Arkansas, USA, post-COVID-19 pandemic
Michelle M. Vanlandingham
National Center for Toxicological Research
2 shared publications
In database
- Evaluating the toxicokinetics of some metabolites of a C6 polyfluorinated compound, 6:2 fluorotelomer alcohol in pregnant and nonpregnant rats after oral exposure to the parent compound
- Wastewater dataset on the SARS-CoV-2 sublineages circulating in Central Arkansas, USA, post-COVID-19 pandemic
J. Hanks
National Center for Toxicological Research
2 shared publications
In database
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
- Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice
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