Match tier
Likely match
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
I
Issam Makhoul
This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.
Medical Director
Also affiliated: Roswell Park Comprehensive Cancer Center (2021); City Of Hope National Medical Center (2017); Pennsylvania State University (2004); Children's Hospital of Los Angeles (1995); University of Wisconsin–Madison (2017); Washington University in St. Louis (2017); University of Arkansas Medical Center (2011–2020); Massachusetts General Hospital (2017); Central Arkansas Veterans Healthcare System (2016); University of Miami Health System (2017); City of Hope (2017); University of Kansas Medical Center (2009–2017); Central Arkansas Radiation Therapy Institute (2022–2026); Penn State Milton S. Hershey Medical Center (2004); The University of Texas Southwestern Medical Center (2022)
27 h-index
159 pubs
2,138 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Issam Makhoul's research focuses on cancer, particularly breast cancer, and its treatment. He has investigated mechanisms of bone metastasis in breast cancer and the relevance of pathological complete response after neoadjuvant therapy. His work also includes exploring the role of immunotherapy in breast cancer treatment and evaluating specific therapeutic regimens, such as the FELINE trial which assessed letrozole plus ribociclib as neoadjuvant therapy.
Makhoul's research extends to understanding resistance mechanisms in early-stage breast cancer, as evidenced by his work on serial single-cell genomics. He has also examined broader cancer risk factors, including the association of age at menarche with site-specific cancer risks. His publications demonstrate an interest in novel diagnostic approaches, such as in vivo liquid biopsies for detecting circulating tumor cells. His scholarship metrics include an h-index of 27, with 159 total publications and 2,134 total citations.
Metrics
- h-index: 27
- Publications: 159
- Citations: 2,138
Positions
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Medical Director 2021–presentCentral Arkansas Radiation Therapy Institute Clinical Research Department ORCID
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Medical Director publications 2004–2026University of Arkansas for Medical Sciences ORCID
Selected Publications
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Baseline proteomic biomarkers for predicting chemotherapy-induced cardiotoxicity in breast cancer patients (2026)
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Neutrophil Biomarkers Can Predict Cardiotoxicity of Anthracyclines in Breast Cancer (2024)
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Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells (2023)
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Abstract 700: Induction of cancer-specific T-cell responses in patients immunized with P10s-PADRE vaccine (2023)
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Data from Association of the Age at Menarche with Site-Specific Cancer Risks in Pooled Data from Nine Cohorts (2023)
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Data from Association of the Age at Menarche with Site-Specific Cancer Risks in Pooled Data from Nine Cohorts (2023)
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Harnessing Antibody Polyspecificity for Cancer Immunotherapy (2022)
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Systematic review of metabolomics approaches in identifying biomarkers of chemotherapy-induced cardiotoxicity among breast cancer patients (2022)
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FEASIBILITY OF SHORT STORY CLUBS IN A HEMATOLOGY/ONCOLOGY PROGRAM (2022)
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Hematology/Oncology Fellowship Programs' Participation in the Quality Oncology Practice Initiative (2022)
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Abstract P2-14-15: Timing of the immunization defines immune signature of a peptide cancer vaccine combined with Neoadjuvant chemotherapy in HR+ breast cancer patients (2022)
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Circulating Exosomal microRNAs as Predictive Biomarkers of Neoadjuvant Chemotherapy Response in Breast Cancer (2022)
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Genome-Wide DNA Methylation Signatures Predict the Early Asymptomatic Doxorubicin-Induced Cardiotoxicity in Breast Cancer (2021)
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Genomic and Transcriptomic Profiling of Brain Metastases (2021)
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Alpelisib-Induced Diabetic Ketoacidosis in a Non-diabetic Patient (2021)
Collaboration Network
Top Collaborators
Eric R. Siegel
University of Arkansas for Medical Sciences
26 shared publications
In database
- In vivo liquid biopsy using Cytophone platform for photoacoustic detection of circulating tumor cells in patients with melanoma
- Targeting tumor-associated carbohydrate antigens: a phase I study of a carbohydrate mimetic-peptide vaccine in stage IV breast cancer subjects
- Bevacizumab and Erlotinib in Previously Untreated Inoperable and Metastatic Hepatocellular Carcinoma
- Moving a Carbohydrate Mimetic Peptide into the clinic
- Dantrolene Attenuates Cardiotoxicity of Doxorubicin Without Reducing its Antitumor Efficacy in a Breast Cancer Model
Showing 5 of 26 shared publications
Laura F. Hutchins
Winthrop Rockefeller Foundation
23 shared publications
In database
- In vivo liquid biopsy using Cytophone platform for photoacoustic detection of circulating tumor cells in patients with melanoma
- Relevance of Pathological Complete Response after Neoadjuvant Therapy for Breast Cancer
- Role of EZH2 histone methyltrasferase in melanoma progression and metastasis
- Targeting tumor-associated carbohydrate antigens: a phase I study of a carbohydrate mimetic-peptide vaccine in stage IV breast cancer subjects
- Immune surveillance in melanoma: From immune attack to melanoma escape and even counterattack
Showing 5 of 23 shared publications
Valentina K. Todorova
University of Arkansas for Medical Sciences
23 shared publications
In database
- Immune response proteins as predictive biomarkers of doxorubicin-induced cardiotoxicity in breast cancer patients
- Biomarkers of inflammation, hypercoagulability and endothelial injury predict early asymptomatic doxorubicin-induced cardiotoxicity in breast cancer patients.
- Transcriptome Profiling of Peripheral Blood Cells Identifies Potential Biomarkers for Doxorubicin Cardiotoxicity in a Rat Model
- Circulating Exosomal microRNAs as Predictive Biomarkers of Neoadjuvant Chemotherapy Response in Breast Cancer
- Circulating miRNA Profiles of Doxorubicin-induced Cardiotoxicity in Breast Cancer Patients.
Showing 5 of 23 shared publications
Thomas Kieber‐Emmons
University of Arkansas for Medical Sciences
18 shared publications
In database
- Relevance of Pathological Complete Response after Neoadjuvant Therapy for Breast Cancer
- Breast Cancer Immunotherapy: An Update
- Targeting tumor-associated carbohydrate antigens: a phase I study of a carbohydrate mimetic-peptide vaccine in stage IV breast cancer subjects
- Moving a Carbohydrate Mimetic Peptide into the clinic
- Harnessing benefit from targeting tumor associated carbohydrate antigens
Showing 5 of 18 shared publications
Angela Pennisi
University of Arkansas for Medical Sciences (US)
15 shared publications
- Relevance of Pathological Complete Response after Neoadjuvant Therapy for Breast Cancer
- Targeting tumor-associated carbohydrate antigens: a phase I study of a carbohydrate mimetic-peptide vaccine in stage IV breast cancer subjects
- Moving a Carbohydrate Mimetic Peptide into the clinic
- Upper-Extremity Deep Vein Thrombosis in Patients With Breast Cancer With Chest Versus Arm Central Venous Port Catheters
- Primary Breast Carcinoma of the Vulva Metastatic to Lymph Nodes and Bones: A Case Report and Literature Review
Showing 5 of 15 shared publications
Jeanne Y. Wei
University of Arkansas for Medical Sciences
14 shared publications
In database
- Immune response proteins as predictive biomarkers of doxorubicin-induced cardiotoxicity in breast cancer patients
- Biomarkers of inflammation, hypercoagulability and endothelial injury predict early asymptomatic doxorubicin-induced cardiotoxicity in breast cancer patients.
- Transcriptome Profiling of Peripheral Blood Cells Identifies Potential Biomarkers for Doxorubicin Cardiotoxicity in a Rat Model
- Circulating miRNA Profiles of Doxorubicin-induced Cardiotoxicity in Breast Cancer Patients.
- Dantrolene Attenuates Cardiotoxicity of Doxorubicin Without Reducing its Antitumor Efficacy in a Breast Cancer Model
Showing 5 of 14 shared publications
Konstantinos Arnaoutakis
University of Arkansas for Medical Sciences
12 shared publications
In database
- Targeting nano drug delivery to cancer cells using tunable, multi‐layer, silver‐decorated gold nanorods
- Cancer patient perspectives regarding preparedness for end-of-life care: A qualitative study
- Addressing Opioid-Associated Constipation Using Quality Oncology Practice Initiative Scores and Plan-Do-Study-Act Cycles
- Rituximab and intermediate-purity plasma-derived factor VIII concentrate (Koate®) as adjuncts to therapeutic plasma exchange for thrombotic thrombocytopenic purpura in patients with an ADAMTS13 inhibitor
- Hematology/Oncology Fellowship Programs' Participation in the Quality Oncology Practice Initiative
Showing 5 of 12 shared publications
Behjatolah Monzavi‐Karbassi
University of Arkansas for Medical Sciences
12 shared publications
In database
- Targeting tumor-associated carbohydrate antigens: a phase I study of a carbohydrate mimetic-peptide vaccine in stage IV breast cancer subjects
- Moving a Carbohydrate Mimetic Peptide into the clinic
- Harnessing benefit from targeting tumor associated carbohydrate antigens
- P10s-PADRE vaccine combined with neoadjuvant chemotherapy in ER-positive breast cancer patients induces humoral and cellular immune responses
- Breast cancer survival disparity between African American and Caucasian women in Arkansas: A race-by-grade analysis
Showing 5 of 12 shared publications
Fade Mahmoud
University of Arkansas for Medical Sciences (US)
11 shared publications
- Role of EZH2 histone methyltrasferase in melanoma progression and metastasis
- Immune surveillance in melanoma: From immune attack to melanoma escape and even counterattack
- Response of metastatic mucosal melanoma to immunotherapy: It can get worse before it gets better
- Cancer patient perspectives regarding preparedness for end-of-life care: A qualitative study
- Outcomes of immunotherapy in advanced melanoma in relation to age.
Showing 5 of 11 shared publications
Fariba Jousheghany
University of Arkansas for Medical Sciences
9 shared publications
In database
- Targeting tumor-associated carbohydrate antigens: a phase I study of a carbohydrate mimetic-peptide vaccine in stage IV breast cancer subjects
- Moving a Carbohydrate Mimetic Peptide into the clinic
- P10s-PADRE vaccine combined with neoadjuvant chemotherapy in ER-positive breast cancer patients induces humoral and cellular immune responses
- Association of DNA-Methylation Profiles With Immune Responses Elicited in Breast Cancer Patients Immunized With a Carbohydrate-Mimicking Peptide: A Pilot Study
- Abstract P6-10-06: Inducing immune responses to tumor associated carbohydrate antigens by a carbohydrate mimetic peptide vaccine: Clinical experience in phase I and phase II trials
Showing 5 of 9 shared publications
Robert J. Griffin
University of Arkansas for Medical Sciences
8 shared publications
In database
- Mechanisms of bone metastases of breast cancer
- Germline Genetic Variants in TEK, ANGPT1, ANGPT2, MMP9, FGF2 and VEGFA Are Associated with Pathologic Complete Response to Bevacizumab in Breast Cancer Patients
- Tumor-endothelial cell interaction in an experimental model of human hepatocellular carcinoma
- Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells
- Therapeutic Implications of Angiogenesis in Cancer
Showing 5 of 8 shared publications
Ishwori Dhakal
University of Arkansas for Medical Sciences (US)
8 shared publications
- Transcriptome Profiling of Peripheral Blood Cells Identifies Potential Biomarkers for Doxorubicin Cardiotoxicity in a Rat Model
- Polymorphic Variations Associated With Doxorubicin-Induced Cardiotoxicity in Breast Cancer Patients
- Germline Genetic Variants in TEK, ANGPT1, ANGPT2, MMP9, FGF2 and VEGFA Are Associated with Pathologic Complete Response to Bevacizumab in Breast Cancer Patients
- Trends in hospitalization outcomes of elderly patients undergoing allogeneic stem cell transplantation for acute myeloid leukemia/myelodysplastic syndrome (AML/MDS).
- Correction: Transcriptome Profiling of Peripheral Blood Cells Identifies Potential Biomarkers for Doxorubicin Cardiotoxicity in a Rat Model
Showing 5 of 8 shared publications
Ping-Ching Hsu
Southwestern Medical Center
8 shared publications
In database
- Biomarkers of inflammation, hypercoagulability and endothelial injury predict early asymptomatic doxorubicin-induced cardiotoxicity in breast cancer patients.
- Genome-Wide DNA Methylation Signatures Predict the Early Asymptomatic Doxorubicin-Induced Cardiotoxicity in Breast Cancer
- Genome-wide DNA methylation signatures to predict pathologic complete response from combined neoadjuvant chemotherapy with bevacizumab in breast cancer
- Association of DNA-Methylation Profiles With Immune Responses Elicited in Breast Cancer Patients Immunized With a Carbohydrate-Mimicking Peptide: A Pilot Study
- Abstract 815: Genome-wide DNA methylation signatures to predict pathologic complete response from combined neoadjuvant chemotherapy with bevacizumab in breast cancer
Showing 5 of 8 shared publications
Paulette Mehta
Central Arkansas Veterans Healthcare System
7 shared publications
In database
- Addressing Opioid-Associated Constipation Using Quality Oncology Practice Initiative Scores and Plan-Do-Study-Act Cycles
- Trends in hospitalization outcomes of elderly patients undergoing allogeneic stem cell transplantation for acute myeloid leukemia/myelodysplastic syndrome (AML/MDS).
- Improving Communication on Intent of Chemotherapy Using QOPI Scores and PDSA Cycles
- Integrating Collaborative Learning and Competition in a Hematology/Oncology Training Program
- Hematology and oncology fellows' attitude and knowledge in cancer pain management.
Showing 5 of 7 shared publications
Susan Kadlubar
University of Arkansas for Medical Sciences
6 shared publications
In database
- Germline Genetic Variants in TEK, ANGPT1, ANGPT2, MMP9, FGF2 and VEGFA Are Associated with Pathologic Complete Response to Bevacizumab in Breast Cancer Patients
- Genome-wide DNA methylation signatures to predict pathologic complete response from combined neoadjuvant chemotherapy with bevacizumab in breast cancer
- Association of DNA-Methylation Profiles With Immune Responses Elicited in Breast Cancer Patients Immunized With a Carbohydrate-Mimicking Peptide: A Pilot Study
- Abstract 2825: Germline genetic variants in ANGPT1 & 2 and FGF2 are associated with pathologic complete response to bevacizumab in breast cancer patients
- Abstract 815: Genome-wide DNA methylation signatures to predict pathologic complete response from combined neoadjuvant chemotherapy with bevacizumab in breast cancer
Showing 5 of 6 shared publications
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