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Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
X
Xiaoqing Guo
High Impact
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34 h-index
181 pubs
3,782 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Xiaoqing Guo's research centers on understanding the molecular mechanisms underlying disease progression and the development of resistance to therapeutic agents. Guo investigates the role of specific molecules and cellular processes in conditions such as atherosclerosis, ovarian cancer, and cervical cancer. Recent work includes studies on the phenotypic switching of vascular smooth muscle cells in atherosclerosis, the promotion of cholesterol uptake and foam cell formation by TREM2 in this disease, and the molecular mechanisms by which CD163+ tumor-associated macrophage-derived exosomes induce cisplatin resistance in ovarian cancer ascites.
Further research areas include evaluating the safety and immunogenicity of vaccines, such as SARS-CoV-2 vaccines in patients with chronic liver diseases. Guo also examines the mutagenicity and genotoxicity of chemical compounds, including N-nitroso propranolol, using in vitro assays. Guo holds a significant scholarly record, with an h-index of 34, 181 total publications, and over 3,700 citations, indicating a high impact in the research community. Guo actively collaborates with researchers at the National Center for Toxicological Research, including Nan Mei, Ji-Eun Seo, Xilin Li, and Robert H. Heflich, with whom multiple shared publications exist.
Metrics
- h-index: 34
- Publications: 181
- Citations: 3,782
Selected Publications
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Mutagenicity of EAT-positive NDSRIs in HepaRG spheroids (2026)
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Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models (2025)
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Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes (2025)
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Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells (2024)
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Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing (2024)
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Application of HepaRG cells for genotoxicity assessment: a review (2024)
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Key Challenges for In Vitro Testing of Tobacco Products for Regulatory Applications: Recommendations for the In Vitro Mouse Lymphoma Assay (2023)
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The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib (2023)
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Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models (2023)
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Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays (2023)
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High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing (2023)
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Quantitative in vitro to in vivo extrapolation of genotoxicity data provides protective estimates of in vivo dose (2022)
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Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s (2022)
Collaboration Network
Top Collaborators
Nan Mei
National Center for Toxicological Research
36 shared publications
In database
- Assessment of the toxic potential of graphene family nanomaterials
- Aloe vera: A review of toxicity and adverse clinical effects
- Review of Ginkgo biloba -induced toxicity, from experimental studies to human case reports
- Silver nanoparticle‐induced mutations and oxidative stress in mouse lymphoma cells
- Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells
Showing 5 of 36 shared publications
Ji‐Eun Seo
National Center for Toxicological Research
16 shared publications
In database
- Genetic toxicity assessment using liver cell models: past, present, and future
- Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Performance of HepaRG and HepG2 cells in the high-throughput micronucleus assay for in vitro genotoxicity assessment
- Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells
Showing 5 of 16 shared publications
Robert H. Heflich
National Center for Toxicological Research
11 shared publications
In database
- Nitroxide TEMPO: A genotoxic and oxidative stress inducer in cultured cells
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Quantitative analysis of the relative mutagenicity of five chemical constituents of tobacco smoke in the mouse lymphoma assay
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
Showing 5 of 11 shared publications
Martha M. Moore
11 shared publications
- Silver nanoparticle‐induced mutations and oxidative stress in mouse lymphoma cells
- Mechanistic Evaluation of Ginkgo biloba Leaf Extract-Induced Genotoxicity in L5178Y Cells
- Nitroxide TEMPO: A genotoxic and oxidative stress inducer in cultured cells
- Mutagenicity of 11 cigarette smoke condensates in two versions of the mouse lymphoma assay
- Quantitative analysis of the relative mutagenicity of five chemical constituents of tobacco smoke in the mouse lymphoma assay
Showing 5 of 11 shared publications
Lei Guo
National Center for Toxicological Research
9 shared publications
In database
- Review of Ginkgo biloba -induced toxicity, from experimental studies to human case reports
- Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells
- ROS generation and JNK activation contribute to 4-methoxy-TEMPO-induced cytotoxicity, autophagy, and DNA damage in HepG2 cells
- Mechanistic Evaluation of Ginkgo biloba Leaf Extract-Induced Genotoxicity in L5178Y Cells
- Nitroxide TEMPO: A genotoxic and oxidative stress inducer in cultured cells
Showing 5 of 9 shared publications
Matthew Bryant
National Center for Toxicological Research
7 shared publications
In database
- Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Performance of high-throughput CometChip assay using primary human hepatocytes: a comparison of DNA damage responses with in vitro human hepatoma cell lines
- Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
Showing 5 of 7 shared publications
Tong Zhou
Center for Veterinary Medicine (US)
7 shared publications
- Cytotoxicity and genotoxicity of cadmium oxide nanoparticles evaluated using in vitro assays
- Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay
- Performance of HepaRG and HepG2 cells in the high-throughput micronucleus assay for in vitro genotoxicity assessment
- High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
Showing 5 of 7 shared publications
Xilin Li
National Center for Toxicological Research
7 shared publications
In database
- Genetic toxicity assessment using liver cell models: past, present, and future
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Aristolochic acid-induced genotoxicity and toxicogenomic changes in rodents
- High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
Showing 5 of 7 shared publications
Timothy J. McGovern
United States Food and Drug Administration (US)
7 shared publications
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
Showing 5 of 7 shared publications
Syed F. Ali
National Center for Toxicological Research
6 shared publications
In database
- Silver nanoparticle‐induced mutations and oxidative stress in mouse lymphoma cells
- Developmental toxicity assay using high content screening of zebrafish embryos
- Acetyl l-carnitine protects motor neurons and Rohon-Beard sensory neurons against ketamine-induced neurotoxicity in zebrafish embryos
- Ketamine attenuates cytochrome p450 aromatase gene expression and estradiol‐17β levels in zebrafish early life stages
- Nicotine alters the expression of molecular markers of endocrine disruption in zebrafish
Showing 5 of 6 shared publications
Stacey L. Dial
National Center for Toxicological Research (US)
6 shared publications
- Mechanistic Evaluation of Ginkgo biloba Leaf Extract-Induced Genotoxicity in L5178Y Cells
- Quantitative analysis of the relative mutagenicity of five chemical constituents of tobacco smoke in the mouse lymphoma assay
- Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells
- Reactive oxygen species and c-Jun N-terminal kinases contribute to TEMPO-induced apoptosis in L5178Y cells
- In vitro investigation of the mutagenic potential of Aloe vera extracts
Showing 5 of 6 shared publications
Aisar Atrakchi
United States Food and Drug Administration (US)
6 shared publications
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
Showing 5 of 6 shared publications
Merle G. Paule
National Center for Toxicological Research
5 shared publications
In database
- Developmental toxicity assay using high content screening of zebrafish embryos
- Acetyl l-carnitine protects motor neurons and Rohon-Beard sensory neurons against ketamine-induced neurotoxicity in zebrafish embryos
- Ketamine attenuates cytochrome p450 aromatase gene expression and estradiol‐17β levels in zebrafish early life stages
- Nicotine alters the expression of molecular markers of endocrine disruption in zebrafish
- Acetyl L ‐carnitine targets adenosine triphosphate synthase in protecting zebrafish embryos from toxicities induced by verapamil and ketamine: An in vivo assessment
Jyotshna Kanungo
National Center for Toxicological Research
5 shared publications
In database
- Developmental toxicity assay using high content screening of zebrafish embryos
- Acetyl l-carnitine protects motor neurons and Rohon-Beard sensory neurons against ketamine-induced neurotoxicity in zebrafish embryos
- Ketamine attenuates cytochrome p450 aromatase gene expression and estradiol‐17β levels in zebrafish early life stages
- Nicotine alters the expression of molecular markers of endocrine disruption in zebrafish
- Acetyl L ‐carnitine targets adenosine triphosphate synthase in protecting zebrafish embryos from toxicities induced by verapamil and ketamine: An in vivo assessment
Patricia Richter
United States Food and Drug Administration (US)
5 shared publications
- Mutagenicity of 11 cigarette smoke condensates in two versions of the mouse lymphoma assay
- Quantitative analysis of the relative mutagenicity of five chemical constituents of tobacco smoke in the mouse lymphoma assay
- Quantitative differentiation of whole smoke solution‐induced mutagenicity in the mouse lymphoma assay
- Differentiating between micronucleus dose-responses induced by whole cigarette smoke solutions with Benchmark Dose potency ranking
- Comparative potency analysis of whole smoke solutions in the bacterial reverse mutation test
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