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Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-06
X
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Xiaoqing Guo's research centers on understanding the molecular mechanisms underlying disease progression and the development of resistance to therapeutic agents. Guo investigates the role of specific molecules and cellular processes in conditions such as atherosclerosis, ovarian cancer, and cervical cancer. Recent work includes studies on the phenotypic switching of vascular smooth muscle cells in atherosclerosis, the promotion of cholesterol uptake and foam cell formation by TREM2 in this disease, and the molecular mechanisms by which CD163+ tumor-associated macrophage-derived exosomes induce cisplatin resistance in ovarian cancer ascites.
Further research areas include evaluating the safety and immunogenicity of vaccines, such as SARS-CoV-2 vaccines in patients with chronic liver diseases. Guo also examines the mutagenicity and genotoxicity of chemical compounds, including N-nitroso propranolol, using in vitro assays. Guo holds a significant scholarly record, with an h-index of 34, 181 total publications, and over 3,700 citations, indicating a high impact in the research community. Guo actively collaborates with researchers at the National Center for Toxicological Research, including Nan Mei, Ji-Eun Seo, Xilin Li, and Robert H. Heflich, with whom multiple shared publications exist.
Metrics
- h-index: 34
- Publications: 181
- Citations: 3,782
Selected Publications
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Mutagenicity of EAT-positive NDSRIs in HepaRG spheroids (2026)
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Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models (2025)
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Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes (2025)
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Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells (2024)
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Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing (2024)
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Application of HepaRG cells for genotoxicity assessment: a review (2024)
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The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib (2023)
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Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models (2023)
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Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays (2023)
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High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing (2023)
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Quantitative in vitro to in vivo extrapolation of genotoxicity data provides protective estimates of in vivo dose (2022)
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Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s (2022)
Collaboration Network
Top Collaborators
Nan Mei
United States Food and Drug Administration
11 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
Showing 5 of 11 shared publications
Ji‐Eun Seo
National Center for Toxicological Research
9 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
Showing 5 of 9 shared publications
Robert H. Heflich
United States Food and Drug Administration
7 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells
Showing 5 of 7 shared publications
Timothy J. McGovern
United States Food and Drug Administration (US)
6 shared publications
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
Showing 5 of 6 shared publications
Yuan Le
United States Food and Drug Administration
5 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells
Aisar Atrakchi
Center for Drug Evaluation and Research (US)
5 shared publications
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
David A. Keire
United States Food and Drug Administration (US)
4 shared publications
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
Xilin Li
National Center for Toxicological Research
4 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
Hannah Xu
United States Food and Drug Administration
4 shared publications
In database
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Application of HepaRG cells for genotoxicity assessment: a review
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
Tong Zhou
Center for Veterinary Medicine (US)
3 shared publications
- High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Mutagenicity of silver nanoparticles evaluated using whole-genome sequencing in mouse lymphoma cells
Xiaobo He
National Center for Toxicological Research
3 shared publications
In database
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta)
Matthew Bryant
National Center for Toxicological Research
3 shared publications
In database
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta)
Xilin Li
United States Food and Drug Administration
3 shared publications
In database
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
Karen Davis‐Bruno
Center for Drug Evaluation and Research (US)
3 shared publications
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells
Sruthi Tallapragada King
United States Food and Drug Administration (US)
3 shared publications
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells
- Mutagenicity of EAT-positive NDSRIs in HepaRG spheroids
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