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Confirmed
Presence
Current · Arkansas
Last published
2026
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OpenAlex · ORCID
Refreshed
2026-10-05
P
Page B. McKinzie
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Research Microbiologist
Also affiliated: United States Food and Drug Administration (2002–2026); Central Arkansas Veterans Healthcare System (2007)
15 h-index
35 pubs
476 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Page B. McKinzie's research focuses on assessing the mutagenic and genotoxic effects of chemical exposures and therapeutic agents. Utilizing molecular biology techniques such as allele-specific competitive blocker PCR (ACB-PCR) and high-fidelity sequencing, McKinzie investigates the induction of mutations in various model systems, including bacterial cells, mammalian cells, and animal models like rats and mice. Recent work has evaluated the mutagenicity of Molnupiravir and N4-hydroxycytidine using HiFi sequencing, and the mutagenicity of N-nitrosodimethylamine in HepaRG cell cultures using error-corrected next-generation sequencing. Further research has examined tumor-associated mutations in the nasal mucosa of rats exposed to formaldehyde and explored the application of oncomutations as biomarkers for chemical risk assessment and cancer risk. McKinzie has a publication record of 36 papers, an h-index of 15, and has been cited 486 times. Key collaborators include Vasily N. Dobrovolsky, Javier R. Revollo, Jaime A. Miranda, and Robert H. Heflich, all from the National Center for Toxicological Research.
Metrics
- h-index: 15
- Publications: 35
- Citations: 476
Positions
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Research Microbiologist publications 2001–2026National Center for Toxicological Research Division of Genetic and Molecular Toxicology ORCID
Selected Publications
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Using error-corrected sequencing for evaluating mutagenicity of molnupiravir in humans (2026)
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Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing (2024)
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Erythrocyte PIG‐A mutant frequencies in cancer patients receiving cisplatin (2024)
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Whole-genome high-fidelity sequencing: A novel approach to detecting and characterization of mutagenicity in vivo (2023)
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Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by HiFi sequencing (2023)
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A Brief Practical Guide to PCR (2023)
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Evaluation of the mutagenic effects of Molnupiravir and N4 ‐hydroxycytidine in bacterial and mammalian cells by HiFi sequencing (2022)
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Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma L5178Y cells and Caenorhabditis elegans worms by PacBio sequencing (2022)
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Mutational signatures in T‐lymphocytes of rats treated with N ‐propyl‐ N‐nitrosourea and procarbazine (2021)
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Pig‐a gene mutations in bone marrow granulocytes of procarbazine‐treated F344 rats (2021)
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A Streamlined and High-Throughput Error-Corrected Next-Generation Sequencing Method for Low Variant Allele Frequency Quantitation (2019)
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Reduced vancomycin susceptibility and increased macrophage survival in Staphylococcus aureus strains sequentially isolated from a bacteraemic patient during a short course of antibiotic therapy (2019)
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Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays (2018)
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Lifespan Kras mutation levels in lung and liver of B6C3F1 mice (2018)
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Spectrum of Pig-a mutations in T lymphocytes of rats treated with procarbazine (2017)
Collaboration Network
Top Collaborators
Javier R. Revollo
National Center for Toxicological Research
16 shared publications
In database
- Evaluation of the mutagenic effects of Molnupiravir and N4 ‐hydroxycytidine in bacterial and mammalian cells by HiFi sequencing
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Spectrum of Pig-a mutations in T lymphocytes of rats treated with procarbazine
- Glycosylphosphatidylinositol (GPI) anchored protein deficiency serves as a reliable reporter of Pig‐a gene Mutation: Support from an in vitro assay based on L5178Y/Tk+/− cells and the CD90.2 antigen
- Spectrum of benzo[ a ]pyrene-induced mutations in the Pig-a gene of L5178Y Tk +/− cells identified with next generation sequencing
Showing 5 of 16 shared publications
Vasily N. Dobrovolsky
National Center for Toxicological Research
15 shared publications
In database
- Evaluation of the mutagenic effects of Molnupiravir and N4 ‐hydroxycytidine in bacterial and mammalian cells by HiFi sequencing
- Spectrum of Pig-a mutations in T lymphocytes of rats treated with procarbazine
- Glycosylphosphatidylinositol (GPI) anchored protein deficiency serves as a reliable reporter of Pig‐a gene Mutation: Support from an in vitro assay based on L5178Y/Tk+/− cells and the CD90.2 antigen
- Spectrum of benzo[ a ]pyrene-induced mutations in the Pig-a gene of L5178Y Tk +/− cells identified with next generation sequencing
- Establishing a novel Pig‐a gene mutation assay in L5178YTk+/− mouse lymphoma cells
Showing 5 of 15 shared publications
Barbara L. Parsons
National Center for Toxicological Research
13 shared publications
In database
- Detection of rare K-ras codon 12 mutations using allele-specific competitive blocker PCR
- ACB-PCR Quantification of K-RASCodon 12 GAT and GTT Mutant Fraction in Colon Tumor and Non-Tumor Tissue
- ACB-PCR Quantification of K-RASCodon 12 GAT and GTT Mutant Fraction in Colon Tumor and Non-Tumor Tissue
- Measurement of tumor-associated mutations in the nasal mucosa of rats exposed to varying doses of formaldehyde
- Oncomutations as biomarkers of cancer risk
Showing 5 of 13 shared publications
Robert H. Heflich
National Center for Toxicological Research
8 shared publications
In database
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Allele-Specific Competitive Blocker–PCR Detection of Rare Base Substitution
- Spectrum of benzo[ a ]pyrene-induced mutations in the Pig-a gene of L5178Y Tk +/− cells identified with next generation sequencing
- Establishing a novel Pig‐a gene mutation assay in L5178YTk+/− mouse lymphoma cells
- Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays
Showing 5 of 8 shared publications
Mason G. Pearce
National Center for Toxicological Research
8 shared publications
In database
- Spectrum of Pig-a mutations in T lymphocytes of rats treated with procarbazine
- Spectrum of benzo[ a ]pyrene-induced mutations in the Pig-a gene of L5178Y Tk +/− cells identified with next generation sequencing
- Establishing a novel Pig‐a gene mutation assay in L5178YTk+/− mouse lymphoma cells
- Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays
- Lifespan Kras mutation levels in lung and liver of B6C3F1 mice
Showing 5 of 8 shared publications
Meagan B. Myers
National Center for Toxicological Research
6 shared publications
In database
- Oncomutations as biomarkers of cancer risk
- ACB-PCR Quantification of Somatic Oncomutation
- Abstract 1739: The prevalence of KRAS, PIK3CA, and BRAF mutant subpopulations in tumors may be impacting the success of personalized cancer treatment
- A Brief Practical Guide to PCR
- Abstract 3179: ACB-PCR quantification of PIK3CA codon 1047 CAT to CGT mutant fraction in human tumor and non-tumor tissues
Showing 5 of 6 shared publications
Fanxue Meng
National Center for Toxicological Research (US)
4 shared publications
- Measurement of tumor-associated mutations in the nasal mucosa of rats exposed to varying doses of formaldehyde
- Oncomutations as biomarkers of cancer risk
- ACB-PCR Quantification of Somatic Oncomutation
- Abstract 3179: ACB-PCR quantification of PIK3CA codon 1047 CAT to CGT mutant fraction in human tumor and non-tumor tissues
Yiying Wang
National Center for Toxicological Research (US)
4 shared publications
- Oncomutations as biomarkers of cancer risk
- Spectrum of benzo[ a ]pyrene-induced mutations in the Pig-a gene of L5178Y Tk +/− cells identified with next generation sequencing
- Establishing a novel Pig‐a gene mutation assay in L5178YTk+/− mouse lymphoma cells
- Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays
Robert R. Delongchamp
University of Arkansas for Medical Sciences
4 shared publications
In database
- ACB-PCR Quantification of K-RASCodon 12 GAT and GTT Mutant Fraction in Colon Tumor and Non-Tumor Tissue
- ACB-PCR Quantification of K-RASCodon 12 GAT and GTT Mutant Fraction in Colon Tumor and Non-Tumor Tissue
- ACB-PCR measurement of K-ras codon 12 mutant fractions in livers of Big Blue(R) rats treated with N-hydroxy-2-acetylaminofluorene
- Quantification of K-RAS codon 12 GAT and GTT mutation in colon tumor and non-tumor tissue by allele-specific competitive blocker PCR
Azra Dad
National Center for Toxicological Research
4 shared publications
In database
- Spectrum of benzo[ a ]pyrene-induced mutations in the Pig-a gene of L5178Y Tk +/− cells identified with next generation sequencing
- Establishing a novel Pig‐a gene mutation assay in L5178YTk+/− mouse lymphoma cells
- Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays
- Pig‐a gene mutations in bone marrow granulocytes of procarbazine‐treated F344 rats
Jaime A. Miranda
National Center for Toxicological Research
4 shared publications
In database
- Evaluation of the mutagenic effects of Molnupiravir and N4 ‐hydroxycytidine in bacterial and mammalian cells by HiFi sequencing
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma L5178Y cells and Caenorhabditis elegans worms by PacBio sequencing
- Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by HiFi sequencing
Karen L. McKim
National Center for Toxicological Research
3 shared publications
In database
- Lifespan Kras mutation levels in lung and liver of B6C3F1 mice
- Abstract 1739: The prevalence of KRAS, PIK3CA, and BRAF mutant subpopulations in tumors may be impacting the success of personalized cancer treatment
- Abstract 3179: ACB-PCR quantification of PIK3CA codon 1047 CAT to CGT mutant fraction in human tumor and non-tumor tissues
Tracie L. Verkler
National Center for Toxicological Research (US)
3 shared publications
- ACB-PCR Quantification of K-RASCodon 12 GAT and GTT Mutant Fraction in Colon Tumor and Non-Tumor Tissue
- ACB-PCR Quantification of K-RASCodon 12 GAT and GTT Mutant Fraction in Colon Tumor and Non-Tumor Tissue
- Quantification of K-RAS codon 12 GAT and GTT mutation in colon tumor and non-tumor tissue by allele-specific competitive blocker PCR
Timothy W. Robison
United States Food and Drug Administration (US)
3 shared publications
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Mutational signatures in T‐lymphocytes of rats treated with N ‐propyl‐ N‐nitrosourea and procarbazine
- Erythrocyte PIG‐A mutant frequencies in cancer patients receiving cisplatin
Suzanne M. Morris
National Center for Toxicological Research (US)
2 shared publications
- Whole genome and normalized mRNA sequencing reveal genetic status of TK6, WTK1, and NH32 human B-lymphoblastoid cell lines
- The 40th anniversary of the Environmental Mutagen Society
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