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Presence
Current · Arkansas
Last published
2026
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OpenAlex · ORCID
Refreshed
2026-10-06
B
Baku Acharya
Ph.D. graduate
Also affiliated: Kathmandu University (2020); Mississippi State University (2020)
7 h-index
75 pubs
149 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Baku Acharya's research centers on cancer therapeutics, with a particular focus on small-molecule inhibitors targeting specific oncogenic pathways. His recent work investigates the development of inhibitors for rearranged during transfection (RET) in various cancers and FLT3 inhibitors for acute myeloid leukemia. Acharya also explores novel therapeutic targets, such as NEK2 in lymphoma, and examines strategies for designing kinase inhibitors, including macrocycles that limit conformational flexibility. His publications span a range of topics, from cancer drug development to educational methods in biochemistry, such as hands-on mass spectrometry for undergraduate students. Acharya has an h-index of 8 with 87 total publications and 209 citations. He collaborates extensively with colleagues at the University of Arkansas for Medical Sciences, including Ying-Zhi Xu, Mason McCrury, Kennith Swafford, and Brendan Frett, with whom he shares numerous publications.
Metrics
- h-index: 7
- Publications: 75
- Citations: 149
Positions
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Ph.D. graduate publications 2021–2026University of Arkansas for Medical Sciences Institution web page
Selected Publications
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Discovery of quinazoline-based dual RET/Aurora B inhibitors for non-small cell lung cancer (2026)
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Epigenetic dysregulation and therapeutic targeting of RET receptor tyrosine kinase in high‐risk KMT2A ‐rearranged acute myeloid leukaemia (2025)
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Discovery of novel 1H-pyrazolo[3,4-d]pyrimidine derivatives as BRK/PTK6 inhibitors (2025)
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Discovery of Novel 1h-Pyrazolo[3,4-D]Pyrimidine Derivatives as Brk/Ptk6 Inhibitors (2025)
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Transforming growth factor β receptor 1 and mitogen-activated protein 4 kinase 4 dual inhibitor, TK-850, reduces renal fibrosis in unilateral ureteral–obstructed mice (2025)
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Epigenetic Dysregulation and Therapeutic Targeting of RET Receptor Tyrosine Kinase in High-Risk KMT2A-Rearranged Pediatric Acute Myeloid Leukemia (2025)
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Discovery of the DNA-PKcs inhibitor DA-143 which exhibits enhanced solubility relative to NU7441 (2024)
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Attenuation of renal injury by administration of TK-850, a dual inhibitor of TGFβR1/MAP4K4 (2024)
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Discovery of 9H-pyrimido[4,5-b]indole derivatives as dual RET/TRKA inhibitors (2024)
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557 Dual TGFβR1/MAP4K4 inhibitor reduces kidney injury in a mouse model of renal fibrosis. (2024)
Collaboration Network
Top Collaborators
Brendan Frett
University of Arkansas for Medical Sciences
17 shared publications
In database
- Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development
- FLT3 inhibitors for acute myeloid leukemia: successes, defeats, and emerging paradigms
- Kinase inhibitor macrocycles: a perspective on limiting conformational flexibility when targeting the kinome with small molecules
- Bifunctional Inhibitor Reveals NEK2 as a Therapeutic Target and Regulator of Oncogenic Pathways in Lymphoma
- Targeting a Novel G-Quadruplex in the CARD11 Oncogene Promoter with Naptho(2,1-b)furan-1-ethanol,2-nitro- Requires the Nitro Group
Showing 5 of 17 shared publications
Debasmita Saha
Discovery Institute (US)
8 shared publications
- Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development
- FLT3 inhibitors for acute myeloid leukemia: successes, defeats, and emerging paradigms
- Kinase inhibitor macrocycles: a perspective on limiting conformational flexibility when targeting the kinome with small molecules
- Bifunctional Inhibitor Reveals NEK2 as a Therapeutic Target and Regulator of Oncogenic Pathways in Lymphoma
- Targeting a Novel G-Quadruplex in the CARD11 Oncogene Promoter with Naptho(2,1-b)furan-1-ethanol,2-nitro- Requires the Nitro Group
Showing 5 of 8 shared publications
Maha Hanafi
Cairo University
6 shared publications
In database
- Kinase inhibitor macrocycles: a perspective on limiting conformational flexibility when targeting the kinome with small molecules
- Discovery of 9H-pyrimido[4,5-b]indole derivatives as dual RET/TRKA inhibitors
- Discovery of the DNA-PKcs inhibitor DA-143 which exhibits enhanced solubility relative to NU7441
- Discovery of Novel 1h-Pyrazolo[3,4-D]Pyrimidine Derivatives as Brk/Ptk6 Inhibitors
- Discovery of novel 1H-pyrazolo[3,4-d]pyrimidine derivatives as BRK/PTK6 inhibitors
Showing 5 of 6 shared publications
Daniel W. Armstrong
University of Arkansas for Medical Sciences
5 shared publications
In database
- FLT3 inhibitors for acute myeloid leukemia: successes, defeats, and emerging paradigms
- Kinase inhibitor macrocycles: a perspective on limiting conformational flexibility when targeting the kinome with small molecules
- Discovery of 9H-pyrimido[4,5-b]indole derivatives as dual RET/TRKA inhibitors
- Discovery of the DNA-PKcs inhibitor DA-143 which exhibits enhanced solubility relative to NU7441
- Discovery of novel 1H-pyrazolo[3,4-d]pyrimidine derivatives as BRK/PTK6 inhibitors
Naga Rajiv Lakkaniga
Indian Institute of Technology Dhanbad (IN)
3 shared publications
- Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development
- FLT3 inhibitors for acute myeloid leukemia: successes, defeats, and emerging paradigms
- Kinase inhibitor macrocycles: a perspective on limiting conformational flexibility when targeting the kinome with small molecules
Sayem Miah
University of Arkansas for Medical Sciences
3 shared publications
In database
- Targeting TGF-β: Triumphs and Challenges
- Discovery of Novel 1h-Pyrazolo[3,4-D]Pyrimidine Derivatives as Brk/Ptk6 Inhibitors
- Discovery of novel 1H-pyrazolo[3,4-d]pyrimidine derivatives as BRK/PTK6 inhibitors
Baha’a Jabali
University of Arkansas for Medical Sciences
3 shared publications
In database
- Kinase inhibitor macrocycles: a perspective on limiting conformational flexibility when targeting the kinome with small molecules
- Discovery of 9H-pyrimido[4,5-b]indole derivatives as dual RET/TRKA inhibitors
- Discovery of quinazoline-based dual RET/Aurora B inhibitors for non-small cell lung cancer
Henry A. Palfrey
University of Arkansas for Medical Sciences
3 shared publications
In database
- 557 Dual TGFβR1/MAP4K4 inhibitor reduces kidney injury in a mouse model of renal fibrosis.
- Attenuation of renal injury by administration of TK-850, a dual inhibitor of TGFβR1/MAP4K4
- Transforming growth factor β receptor 1 and mitogen-activated protein 4 kinase 4 dual inhibitor, TK-850, reduces renal fibrosis in unilateral ureteral–obstructed mice
Samaneh Goorani
University of Arkansas for Medical Sciences
3 shared publications
In database
- 557 Dual TGFβR1/MAP4K4 inhibitor reduces kidney injury in a mouse model of renal fibrosis.
- Attenuation of renal injury by administration of TK-850, a dual inhibitor of TGFβR1/MAP4K4
- Transforming growth factor β receptor 1 and mitogen-activated protein 4 kinase 4 dual inhibitor, TK-850, reduces renal fibrosis in unilateral ureteral–obstructed mice
John D. Imig
University of Arkansas Medical Center
3 shared publications
In database
- 557 Dual TGFβR1/MAP4K4 inhibitor reduces kidney injury in a mouse model of renal fibrosis.
- Attenuation of renal injury by administration of TK-850, a dual inhibitor of TGFβR1/MAP4K4
- Transforming growth factor β receptor 1 and mitogen-activated protein 4 kinase 4 dual inhibitor, TK-850, reduces renal fibrosis in unilateral ureteral–obstructed mice
Katie R. Ryan
University of Arkansas for Medical Sciences
2 shared publications
In database
- Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development
- Discovery of 9H-pyrimido[4,5-b]indole derivatives as dual RET/TRKA inhibitors
Noemi Garcia Garcia
University of Arkansas for Medical Sciences
2 shared publications
In database
- Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development
- Discovery of 9H-pyrimido[4,5-b]indole derivatives as dual RET/TRKA inhibitors
Kennith Swafford
University of Arkansas for Medical Sciences
2 shared publications
In database
- Bifunctional Inhibitor Reveals NEK2 as a Therapeutic Target and Regulator of Oncogenic Pathways in Lymphoma
- Targeting a Novel G-Quadruplex in the CARD11 Oncogene Promoter with Naptho(2,1-b)furan-1-ethanol,2-nitro- Requires the Nitro Group
Ying-Zhi Xu
University of Arkansas for Medical Sciences
2 shared publications
In database
- Bifunctional Inhibitor Reveals NEK2 as a Therapeutic Target and Regulator of Oncogenic Pathways in Lymphoma
- Targeting a Novel G-Quadruplex in the CARD11 Oncogene Promoter with Naptho(2,1-b)furan-1-ethanol,2-nitro- Requires the Nitro Group
Mason McCrury
University of Arkansas for Medical Sciences
2 shared publications
In database
- Bifunctional Inhibitor Reveals NEK2 as a Therapeutic Target and Regulator of Oncogenic Pathways in Lymphoma
- Targeting a Novel G-Quadruplex in the CARD11 Oncogene Promoter with Naptho(2,1-b)furan-1-ethanol,2-nitro- Requires the Nitro Group
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