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Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-09
R
Rupak Pathak
Federal Grant PI
High Impact
Associate Professor
Also affiliated: Uniformed Services University of the Health Sciences (2009); Saha Institute of Nuclear Physics (2007); Manipal Academy of Higher Education (2007); University of Arkansas Medical Center (2024); Central Arkansas Veterans Healthcare System (2013–2014); Maulana Abul Kalam Azad University of Technology, West Bengal (2007)
Radiation Health, College of Pharmacy
23 h-index
95 pubs
1,322 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Rupak Pathak, Associate Professor in Radiation Health at the University of Arkansas for Medical Sciences, studies the biological effects of ionizing radiation and other environmental stressors. His research investigates mechanisms of DNA damage and repair, gene expression regulation, and the development of radiation-induced injuries. Pathak's work has explored the role of specific genes and pathways, such as EEPD1 and PARP1, in maintaining genome stability and responding to DNA damage. He also examines the impact of environmental factors, including particulate matter and dietary components like methionine, on cellular processes and epigenetic modifications.
Pathak leads a research group and has secured federal funding, including a $636,257 NIH grant as Principal Investigator for a project examining platelets in radiation-induced immune dysregulation. His scholarship metrics include an h-index of 23, with 98 publications and over 1,343 citations. He has a history of collaboration with researchers at the University of Arkansas for Medical Sciences, including Martin Hauer-Jensen, Regina Lichti Binz, Marjan Boerma, and Igor Koturbash, with whom he has co-authored multiple publications.
Metrics
- h-index: 23
- Publications: 95
- Citations: 1,322
Positions
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Associate Professor 2023–presentUniversity of Arkansas for Medical Sciences Radiation Health, College of Pharmacy Institutional directory
Selected Publications
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Gene Expression Profile of Gm20594 and Hapln1 in Mouse Cardiac Muscle Exposed to Microgravity and Space-like Chronic Low-Dose Radiation (2025)
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The hidden hand of endoplasmic reticulum stress in anticancer drug resistance (2025)
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Geranylgeranyl Transferase Inhibitors Mitigate Intestinal Radiation Toxicity (2025)
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Musculoskeletal miRNA profiling after exposure to simulated space stressors in mice (2025)
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Trimethylamine N-Oxide (TMAO) and cancer risk: Insights into a possible link (2025)
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Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice (2025)
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Sex-specific immune alterations in mice following long-term simulated microgravity and chronic irradiation (2025)
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591 Low kidney mass contributes to enhanced fractionated irradiation-induced renal hemodynamic dysfunction in mice (2025)
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Targeting Platelets and NK Cells to Improve Radiation Therapy Outcomes (2024)
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Current Insights into Molecular Mechanisms and Potential Biomarkers for Treating Radiation-Induced Liver Damage (2024)
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G-Banding and Molecular Cytogenetics Detect Novel Translocations and Cryptic Aberrations in Human Immortal Endothelial Cells (2024)
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Azido derivatives of sesquiterpene lactones: Synthesis, anticancer proliferation, and chemistry of nitrogen-centered radicals (2024)
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Platelets, inflammation, and purinergic receptors in chronic kidney disease (2024)
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Understanding the molecular mechanism responsible for developing therapeutic radiation-induced radioresistance of rectal cancer and improving the clinical outcomes of radiotherapy - A review (2024)
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Protocol for preparation and staining of chromosomes isolated from mouse and human tissues for conventional and molecular cytogenetic analysis (2024)
Federal Grants 1 $636,257 total
NIH
Contact PI
Jul 2022 - May 2027
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Effect of microgravity and GT3 on proton-induced genomic instability in endothelial cells National Aeronautics & Space Administration via Arkansas Space Grant Consortium Principal Investigator
- Advanced Drug Development of Gamma-Tocotrienol as a Radiation Countermeasure in Rhesus Macaque Non-Human Primates Defense Threat Reduction Agency via Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Co-Investigator
- Ionizing radiation induced hematological malignancies NIH/Nat. Cancer Institute via University of Florida Principal Investigator
- Team Leader for the Radiation Effects Team National Space Biomedical Research Institute via Baylor College of Medicine Co-Investigator
- Center for Studies of Host Response to Cancer Therapy NIH Co-Investigator
- Ionizing radiation induced hematological malignancies NIH Principal Investigator
- Development of a fast and sensitive biodosimetry assay using molecular cytogenetics. NIH/Nat. Inst. of Allergy & Infectious Diseases via Columbia University Medical Center Principal Investigator
- Safeguarding vascular endothelial damage during deep-space missions by newly designed water-soluble vitamin E formulation National Aeronautics & Space Administration via University of Arkansas at Little Rock Principal Investigator
- Effect of microgravity and GT3 on radiation-induced genomic instability in endothelial cells Arkansas Space Grant Consortium via University of Arkansas at Little Rock Principal Investigator
- Arkansas Center for Health Disparities (ARCHD): An NIMHD COE NIH Co-Investigator
- Studies of Endothelial Dysfunction under Simulated Space Environment National Aeronautics & Space Administration via Arkansas Space Grant Consortium Principal Investigator
- Advanced Development of Gamma-Tocotrienol as a Radiation Countermeasure US Department of Defense via Armed Forces Radiobiology Research Institute Co-Investigator
- Tocotrienol as a countermeasure against high-energy charged particle-induced carcinogenesis, cardiovascular disease, and central nervous system effects- Resubmission National Aeronautics & Space Administration Co-Investigator
- Preventing immune system dysregulation during deep-space missions by Tocofexol, a modified isomer of vitamin E - AA request National Aeronautics & Space Administration via Arkansas Space Grant Consortium Principal Investigator
Collaboration Network
Top Collaborators
Martin Hauer‐Jensen
University of Arkansas for Medical Sciences
46 shared publications
In database
- EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair
- PARP1 is required for chromosomal translocations
- Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
- Reduction of Radiation-Induced Vascular Nitrosative Stress by the Vitamin E Analog γ-Tocotrienol: Evidence of a Role for Tetrahydrobiopterin
- Densely ionizing radiation affects DNA methylation of selective LINE-1 elements
Showing 5 of 46 shared publications
Marjan Boerma
University of Arkansas for Medical Sciences
19 shared publications
In database
- Reduction of Radiation-Induced Vascular Nitrosative Stress by the Vitamin E Analog γ-Tocotrienol: Evidence of a Role for Tetrahydrobiopterin
- C/EBPδ Deficiency Sensitizes Mice to Ionizing Radiation-Induced Hematopoietic and Intestinal Injury
- The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage
- Thrombomodulin Contributes to Gamma Tocotrienol-Mediated Lethality Protection and Hematopoietic Cell Recovery in Irradiated Mice
- Characterization of Transgenic Gfrp Knock-In Mice: Implications for Tetrahydrobiopterin in Modulation of Normal Tissue Radiation Responses
Showing 5 of 19 shared publications
Igor Koturbash
University of Arkansas for Medical Sciences
18 shared publications
In database
- Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
- Densely ionizing radiation affects DNA methylation of selective LINE-1 elements
- In VitroToxicity and Epigenotoxicity of Different Types of Ambient Particulate Matter
- Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation
- The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage
Showing 5 of 18 shared publications
Isabelle R. Miousse
University of Arkansas for Medical Sciences
12 shared publications
In database
- Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
- Densely ionizing radiation affects DNA methylation of selective LINE-1 elements
- In VitroToxicity and Epigenotoxicity of Different Types of Ambient Particulate Matter
- Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation
- Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome
Showing 5 of 12 shared publications
Daohong Zhou
University of Florida (US)
11 shared publications
- EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair
- PARP1 is required for chromosomal translocations
- Latexin sensitizes leukemogenic cells to gamma-irradiation-induced cell-cycle arrest and cell death through Rps3 pathway
- Identification of novel breakpoints for locus- and region-specific translocations in 293 cells by molecular cytogenetics before and after irradiation
- C/EBPδ Deficiency Sensitizes Mice to Ionizing Radiation-Induced Hematopoietic and Intestinal Injury
Showing 5 of 11 shared publications
Sanchita Ghosh
10 shared publications
- Metabolomic changes in gastrointestinal tissues after whole body radiation in a murine model
- Gamma-Tocotrienol Modulates Radiation-Induced MicroRNA Expression in Mouse Spleen
- The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage
- Liver Metabolomics Reveals Increased Oxidative Stress and Fibrogenic Potential in Gfrp Transgenic Mice in Response to Ionizing Radiation
- Thrombomodulin Contributes to Gamma Tocotrienol-Mediated Lethality Protection and Hematopoietic Cell Recovery in Irradiated Mice
Showing 5 of 10 shared publications
Sarita Garg
University of Arkansas for Medical Sciences
8 shared publications
In database
- Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
- Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome
- Characterization of Transgenic Gfrp Knock-In Mice: Implications for Tetrahydrobiopterin in Modulation of Normal Tissue Radiation Responses
- Simultaneous exposure to chronic irradiation and simulated microgravity differentially alters immune cell phenotype in mouse thymus and spleen
- Gamma-Tocotrienol Protects the Intestine from Radiation Potentially by Accelerating Mesenchymal Immune Cell Recovery
Showing 5 of 8 shared publications
Nükhet Aykin‐Burns
University of Arkansas for Medical Sciences
8 shared publications
In database
- In VitroToxicity and Epigenotoxicity of Different Types of Ambient Particulate Matter
- Liver Metabolomics Reveals Increased Oxidative Stress and Fibrogenic Potential in Gfrp Transgenic Mice in Response to Ionizing Radiation
- Characterization of Transgenic Gfrp Knock-In Mice: Implications for Tetrahydrobiopterin in Modulation of Normal Tissue Radiation Responses
- Utilization of Vitamin E Analogs to Protect Normal Tissues While Enhancing Antitumor Effects
- Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
Showing 5 of 8 shared publications
Regina Lichti Binz
University of Arkansas for Medical Sciences
8 shared publications
In database
- Identification of novel breakpoints for locus- and region-specific translocations in 293 cells by molecular cytogenetics before and after irradiation
- The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage
- Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- Evaluating the effects of low-dose simulated galactic cosmic rays on murine hippocampal-dependent cognitive performance
Showing 5 of 8 shared publications
Charles M. Skinner
University of Arkansas for Medical Sciences
7 shared publications
In database
- Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
- Densely ionizing radiation affects DNA methylation of selective LINE-1 elements
- Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome
- Dietary Methionine Supplementation Exacerbates Gastrointestinal Toxicity in a Mouse Model of Abdominal Irradiation
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
Showing 5 of 7 shared publications
Vijayalakshmi Sridharan
University of Arkansas for Medical Sciences
6 shared publications
In database
- Characterization of Transgenic Gfrp Knock-In Mice: Implications for Tetrahydrobiopterin in Modulation of Normal Tissue Radiation Responses
- Low Doses of Oxygen Ion Irradiation Cause Acute Damage to Hematopoietic Cells in Mice
- Low doses of oxygen ion irradiation cause long-term damage to bone marrow hematopoietic progenitor and stem cells in mice
- Whole body proton irradiation causes acute damage to bone marrow hematopoietic progenitor and stem cells in mice
- Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model
Showing 5 of 6 shared publications
Kimberly J. Krager
University of Arkansas for Medical Sciences
6 shared publications
In database
- In VitroToxicity and Epigenotoxicity of Different Types of Ambient Particulate Matter
- Characterization of Transgenic Gfrp Knock-In Mice: Implications for Tetrahydrobiopterin in Modulation of Normal Tissue Radiation Responses
- Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
- Modulation of Radiation Response by the Tetrahydrobiopterin Pathway
- Fractionated radiation suppresses Kruppel-like factor 2 pathway to a greater extent than by single exposure to the same total dose
Showing 5 of 6 shared publications
Stepan Melnyk
University of Arkansas for Medical Sciences
6 shared publications
In database
- Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
- Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome
- Cebpd Is Essential for Gamma-Tocotrienol Mediated Protection against Radiation-Induced Hematopoietic and Intestinal Injury
- Dietary Methionine Supplementation Exacerbates Gastrointestinal Toxicity in a Mouse Model of Abdominal Irradiation
- Methods for induction and assessment of intestinal permeability in rodent models of radiation injury
Showing 5 of 6 shared publications
Snehalata A. Pawar
University of Arkansas for Medical Sciences (US)
5 shared publications
- C/EBPδ Deficiency Sensitizes Mice to Ionizing Radiation-Induced Hematopoietic and Intestinal Injury
- Characterization of Transgenic Gfrp Knock-In Mice: Implications for Tetrahydrobiopterin in Modulation of Normal Tissue Radiation Responses
- Cebpd Is Essential for Gamma-Tocotrienol Mediated Protection against Radiation-Induced Hematopoietic and Intestinal Injury
- Simultaneous exposure to chronic irradiation and simulated microgravity differentially alters immune cell phenotype in mouse thymus and spleen
- Gamma-Tocotrienol Protects the Intestine from Radiation Potentially by Accelerating Mesenchymal Immune Cell Recovery
Gregory A. Nelson
Loma Linda University (US)
5 shared publications
- Densely ionizing radiation affects DNA methylation of selective LINE-1 elements
- Low Doses of Oxygen Ion Irradiation Cause Acute Damage to Hematopoietic Cells in Mice
- Combined exposure to protons and 56Fe leads to overexpression of Il13 and reactivation of repetitive elements in the mouse lung
- Low doses of oxygen ion irradiation cause long-term damage to bone marrow hematopoietic progenitor and stem cells in mice
- Whole body proton irradiation causes acute damage to bone marrow hematopoietic progenitor and stem cells in mice
Similar Researchers
Based on overlapping research topics
Isabelle Racine Miousse
University of Arkansas for Medical Sciences
Radiation Therapy and Dosimetry
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Immune Response and Inflammation
Marie Burdine
University of Arkansas for Medical Sciences
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Sarita Garg
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Christopher E. Randolph
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Kathleen A. Bridges
University of Arkansas at Monticello
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Igor Koturbash
University of Arkansas for Medical Sciences
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Epigenetics and DNA Methylation
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