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Listed
Presence
Current · Arkansas
Last published
2024
Sources
OpenAlex · ORCID
Refreshed
2026-08-06
M
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Melanie Barker's research investigates the role of DNA-PKcs in immune cell function and the potential of povidone-iodine irrigation in managing abdominal abscesses. Her work has demonstrated that chemical inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4+ helper and CD8+ effector T cells. Further research has shown that DNA-PKcs is required for the activation and cytotoxicity of CD8+ effector T cells. In a separate line of inquiry, Barker's studies in a murine model of perforated appendicitis indicate that intra-peritoneal povidone-iodine irrigation can decrease the incidence of abscesses. She has published four papers and has a h-index of 2. Barker collaborates with researchers at the University of Arkansas for Medical Sciences, including Lauren Appell and Ana Clara P. Azevedo‐Pouly, with whom she shares three co-authored publications.
Metrics
- h-index: 2
- Publications: 4
- Citations: 8
Selected Publications
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Intra-peritoneal Povidone-iodine Irrigation Decreases Abscesses in a Perforated Appendicitis Murine Model (2024)
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Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells (2023)
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DNA-PKcs is required for the activation and cytotoxicity of CD8+ effector T cells (2022)
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Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells (2022)
Collaboration Network
Top Collaborators
Zachary J. Waldrip
University of Arkansas for Medical Sciences
4 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Intra-peritoneal Povidone-iodine Irrigation Decreases Abscesses in a Perforated Appendicitis Murine Model
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells
- DNA-PKcs is required for the activation and cytotoxicity of CD8+ effector T cells
Marie Burdine
University of Arkansas for Medical Sciences (US)
4 shared publications
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Intra-peritoneal Povidone-iodine Irrigation Decreases Abscesses in a Perforated Appendicitis Murine Model
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells
- DNA-PKcs is required for the activation and cytotoxicity of CD8+ effector T cells
Ana Clara P. Azevedo‐Pouly
Arkansas Children's Hospital
3 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells
- DNA-PKcs is required for the activation and cytotoxicity of CD8+ effector T cells
Lauren Appell
Arkansas Children's Hospital
3 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells
- DNA-PKcs is required for the activation and cytotoxicity of CD8+ effector T cells
Lyle Burdine
University of Arkansas for Medical Sciences
3 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells
- DNA-PKcs is required for the activation and cytotoxicity of CD8+ effector T cells
Lora J. Rogers
University of Arkansas for Medical Sciences
2 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells
Lauren C. Morehead
University of Arkansas for Medical Sciences
2 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells
Brian Koss
University of Arkansas for Medical Sciences
2 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells
Daniel Fil
University of Arkansas for Medical Sciences
1 shared publication
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
Randall R Rainwater
Arkansas Children's Hospital
1 shared publication
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
Derek Krinock
1 shared publication
In database
- Intra-peritoneal Povidone-iodine Irrigation Decreases Abscesses in a Perforated Appendicitis Murine Model
Krista Stephenson
University of Arkansas for Medical Sciences
1 shared publication
In database
- Intra-peritoneal Povidone-iodine Irrigation Decreases Abscesses in a Perforated Appendicitis Murine Model
David Irby
University of Arkansas for Medical Sciences
1 shared publication
In database
- Intra-peritoneal Povidone-iodine Irrigation Decreases Abscesses in a Perforated Appendicitis Murine Model
Chary Akmyradov
Arkansas Children's Hospital
1 shared publication
In database
- Intra-peritoneal Povidone-iodine Irrigation Decreases Abscesses in a Perforated Appendicitis Murine Model
Lindsey L. Wolf
Arkansas Children's Hospital
1 shared publication
In database
- Intra-peritoneal Povidone-iodine Irrigation Decreases Abscesses in a Perforated Appendicitis Murine Model
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