Philip Palade
Professor
Also affiliated: Rutgers, The State University of New Jersey (1983); Muscular Dystrophy Association (1983); Haverford College (1968); University of Cologne (1994); Anhui Medical University (2013); Vanderbilt University (1983–1984); University of Washington (1977–1985); San Diego State University (1994–2001); United States Public Health Service (1983); California University of Pennsylvania (1977); National Postdoctoral Association (1983); First Affiliated Hospital of Anhui Medical University (2013); Institute of Pharmacology (2009); The University of Texas Medical Branch at Galveston (1983–2006); La Roche College (1983); Southern Medical University (2013); Seattle University (1985); Rice University (2010); Saarland University (1980–1981)
Faculty Researcher
Pharmacology & Toxicology, College of Medicine
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Philip Palade's research investigates the molecular mechanisms underlying various diseases, with a recent focus on cardiovascular diseases and neurodegenerative conditions. His work has explored the role of PCSK9 in smooth muscle cell senescence and apoptosis, suggesting new therapeutic targets beyond cholesterol metabolism for cardiovascular conditions. Additionally, his group studies the involvement of RALBP1 in oxidative stress and mitochondrial dysfunction, particularly in the context of Alzheimer's disease and mammary carcinogenesis, examining its interactions with other key proteins like p53.
His research also extends to the impact of dietary components on health, including the investigation of sulforaphane's effects on skin aging via the Keap1-Nrf2 pathway and the anticancer activity of omega-6 fatty acids through 4-HNE in breast cancer cells. Palade's laboratory is active in leading research groups and maintains a collaborative network, evidenced by multiple shared publications with colleagues at the University of Arkansas for Medical Sciences, including Sharda P. Singh and Chhanda Bose.
With a career marked by significant scholarly output, Palade has accumulated 127 publications and over 5,125 citations, achieving an h-index of 39. He is recognized as a highly cited researcher, reflecting the impact of his contributions to the fields of pharmacology and toxicology.
Metrics
- h-index: 39
- Publications: 128
- Citations: 5,133
Selected Publications
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Uncovering immune pathways for therapeutic targeting of hypertension (2025)
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Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications (2025)
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The pleiotropic effects of PCSK9 in cardiovascular diseases beyond cholesterol metabolism (2025)
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Direct Impact of PCSK9 on SMC Senescence and Apoptosis: A New Focus in Cardiovascular Diseases (2024)
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Book Review of Heart Disease: It is All in Your Head, and What to Do About It (2022)
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Rlip Depletion Alters Oncogene Transcription at Multiple Distinct Regulatory Levels (2022)
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Anticancer Activity of Ω-6 Fatty Acids through Increased 4-HNE in Breast Cancer Cells (2021)
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RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease (2021)
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Role of RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease (2021)
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Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway (2021)
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Haploinsufficiency Interactions between RALBP1 and p53 in ERBB2 and PyVT Models of Mouse Mammary Carcinogenesis (2021)
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Multi-omic analysis reveals the anti-aging impact of sulforaphane on the microbiome and metabolome (2020)
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KATP Channel Openers Inhibit Lymphatic Contractions and Lymph Flow as a Possible Mechanism of Peripheral Edema (2020)
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Sulforaphane prevents age‐associated cardiac and muscular dysfunction through Nrf2 signaling (2020)
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Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice (2020)
Grants & Funding
As listed on this researcher's institutional profile.
- CALCIUM RELEASE FROM ISOLATED SARCOPLASMIC RETICULUM NIH Principal Investigator
- Cav1.2 Transcript Regulation in Heart and Smooth Muscle NIH Principal Investigator
- RNA interference to decrease vascular CaV1.2 in hypertension American Heart Association (South Central Affiliate) Principal Investigator
- THE ALPHA-1C CALCIUM CHANNEL IN MUSCLE NIH Principal Investigator
- CA RELEASE FROM SARCOPLASMIC RETICULUM: THE FROG PACKAGE NIH Principal Investigator
- PHARMACOLOGY OF MUSCLE EXCITATION-CONTRACTION COUPLING NIH Principal Investigator
- CALCIUM RELEASE PROCESS OF SARCOPLASMIC RETICULUM NIH Principal Investigator
- MicroRNA to decrease vascular CaV1.2 in hypertension NIH Principal Investigator
- PHARMACOLOGY OF QUANTAL INTRACELLULAR CALCIUM RELEASE NIH Principal Investigator
- CA INDUCED CA RELEASE FROM STRIATED MUSCLE NIH Principal Investigator
Collaboration Network
Top Collaborators
- RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway
- Anticancer Activity of Ω-6 Fatty Acids through Increased 4-HNE in Breast Cancer Cells
- Haploinsufficiency Interactions between RALBP1 and p53 in ERBB2 and PyVT Models of Mouse Mammary Carcinogenesis
- Role of RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
Showing 5 of 6 shared publications
- RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway
- Anticancer Activity of Ω-6 Fatty Acids through Increased 4-HNE in Breast Cancer Cells
- Haploinsufficiency Interactions between RALBP1 and p53 in ERBB2 and PyVT Models of Mouse Mammary Carcinogenesis
- Role of RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
Showing 5 of 6 shared publications
- RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- Anticancer Activity of Ω-6 Fatty Acids through Increased 4-HNE in Breast Cancer Cells
- Haploinsufficiency Interactions between RALBP1 and p53 in ERBB2 and PyVT Models of Mouse Mammary Carcinogenesis
- Role of RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- Rlip Depletion Alters Oncogene Transcription at Multiple Distinct Regulatory Levels
- RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- Anticancer Activity of Ω-6 Fatty Acids through Increased 4-HNE in Breast Cancer Cells
- Haploinsufficiency Interactions between RALBP1 and p53 in ERBB2 and PyVT Models of Mouse Mammary Carcinogenesis
- Rlip Depletion Alters Oncogene Transcription at Multiple Distinct Regulatory Levels
- Anticancer Activity of Ω-6 Fatty Acids through Increased 4-HNE in Breast Cancer Cells
- Haploinsufficiency Interactions between RALBP1 and p53 in ERBB2 and PyVT Models of Mouse Mammary Carcinogenesis
- Rlip Depletion Alters Oncogene Transcription at Multiple Distinct Regulatory Levels
- RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- Role of RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- Rlip Depletion Alters Oncogene Transcription at Multiple Distinct Regulatory Levels
- Anticancer Activity of Ω-6 Fatty Acids through Increased 4-HNE in Breast Cancer Cells
- Haploinsufficiency Interactions between RALBP1 and p53 in ERBB2 and PyVT Models of Mouse Mammary Carcinogenesis
- Anticancer Activity of Ω-6 Fatty Acids through Increased 4-HNE in Breast Cancer Cells
- Haploinsufficiency Interactions between RALBP1 and p53 in ERBB2 and PyVT Models of Mouse Mammary Carcinogenesis
- RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- Role of RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- Role of RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- Role of RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- Role of RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- Role of RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- Role of RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- Role of RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
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