Philip Palade

High Impact

Professor

University of Arkansas for Medical Sciences

faculty

Pharmacology & Toxicology, College of Medicine

39 h-index 128 pubs 5,100 cited

Research Areas

Neuroinflammation and Neurodegeneration Mechanisms Cardiovascular Function and Risk Factors Cancer-related molecular mechanisms research Mitochondrial Function and Pathology Immune Response and Inflammation Pharmacological Effects and Toxicity Studies Diet and metabolism studies Phytochemicals and Antioxidant Activities

Links

ORCID Lab Website Research Group UAMS TRI Profile

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OverviewAI-generated summary

Philip Palade's research focuses on the molecular mechanisms underlying disease, with recent work investigating the role of specific proteins and pathways in conditions such as Alzheimer's disease, cardiovascular diseases, and cancer.

His investigations into Alzheimer's disease center on the protein RALBP1 and its involvement in oxidative stress and mitochondrial dysfunction. Palade also studies the impact of PCSK9 on vascular smooth muscle cell senescence and apoptosis, and its broader effects on cardiovascular health beyond cholesterol metabolism. His work on cancer includes examining the anticancer activity of omega-6 fatty acids and the interplay of RALBP1 and p53 in mammary carcinogenesis.

Further research interests include the therapeutic targeting of immune pathways for hypertension and the effects of sulforaphane on skin aging via the Keap1-Nrf2 pathway. Palade is a highly cited researcher with an h-index of 39 and over 5,100 citations across 128 publications. He collaborates with several researchers at the University of Arkansas for Medical Sciences, including Sharda P. Singh and Chhanda Bose.

Metrics

  • h-index: 39
  • Publications: 128
  • Citations: 5,100

Selected Publications

  • Uncovering immune pathways for therapeutic targeting of hypertension (2025) DOI
  • Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications (2025) DOI
  • The pleiotropic effects of PCSK9 in cardiovascular diseases beyond cholesterol metabolism (2025) DOI
  • Book Review of Heart Disease: It is All in Your Head, and What to Do About It (2022) DOI
  • Rlip Depletion Alters Oncogene Transcription at Multiple Distinct Regulatory Levels (2022) DOI
  • Anticancer Activity of Ω-6 Fatty Acids through Increased 4-HNE in Breast Cancer Cells (2021) DOI
  • RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease (2021) DOI
  • Role of RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease (2021) DOI
  • Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway (2021) DOI
  • Haploinsufficiency Interactions between RALBP1 and p53 in ERBB2 and PyVT Models of Mouse Mammary Carcinogenesis (2021) DOI

Grants & Funding

  • CALCIUM RELEASE FROM ISOLATED SARCOPLASMIC RETICULUM NIH Principal Investigator
  • Cav1.2 Transcript Regulation in Heart and Smooth Muscle NIH Principal Investigator
  • RNA interference to decrease vascular CaV1.2 in hypertension American Heart Association (South Central Affiliate) Principal Investigator
  • THE ALPHA-1C CALCIUM CHANNEL IN MUSCLE NIH Principal Investigator
  • CA RELEASE FROM SARCOPLASMIC RETICULUM: THE FROG PACKAGE NIH Principal Investigator
  • PHARMACOLOGY OF MUSCLE EXCITATION-CONTRACTION COUPLING NIH Principal Investigator
  • CALCIUM RELEASE PROCESS OF SARCOPLASMIC RETICULUM NIH Principal Investigator
  • CALCIUM RELEASE PROCESS OF SARCOPLASMIC RETICULUM NIH Principal Investigator

Collaborators

Researchers in the database who share publications

Sharda P. Singh University of Arkansas for Medical Sciences 6 shared publications Chhanda Bose University of Arkansas for Medical Sciences 5 shared publications Yunmeng Liu University of Arkansas for Medical Sciences 2 shared publications Katherine Deck University of Arkansas for Medical Sciences 2 shared publications Shengyu Mu University of Arkansas for Medical Sciences 2 shared publications Pamela I. Rogers University of Arkansas for Medical Sciences 2 shared publications Shuoqiu Deng University of Arkansas for Medical Sciences 2 shared publications Tonya Rafferty University of Arkansas for Medical Sciences 2 shared publications

Similar Researchers

Based on overlapping research topics

Si Chen National Center for Toxicological Research
Cardiovascular Function and Risk Factors Cancer-related molecular mechanisms research Mitochondrial Function and Pathology
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Grishma KC University of Arkansas for Medical Sciences
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Yingni Che University of Arkansas for Medical Sciences
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Ambika Verma University of Arkansas for Medical Sciences
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Ashley Nemec-Bakk University of Arkansas for Medical Sciences
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Esraa Shosha University of Arkansas for Medical Sciences
Neuroinflammation and Neurodegeneration Mechanisms Mitochondrial Function and Pathology Immune Response and Inflammation
Good match 5 shared topics