Sharon D. Shelton
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Researcher
Also affiliated: United States Food and Drug Administration (2005–2015); Dalian Medical University (2014); Thomas Jefferson National Accelerator Facility (2006); Food and Drug Administration (2008)
Faculty Researcher
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Sharon D. Shelton's research focuses on genotoxicity assessment and the evaluation of potential mutagens and carcinogens. Her work has investigated the mechanistic effects of compounds like black cohosh extract on human cells, examining their genotoxic potential. She employs various mutagenicity tests, often utilizing bacterial systems such as Escherichia coli and specific enzymes like hypoxanthine phosphoribosyltransferase to detect genetic mutations. Shelton's research also extends to the study of carcinogens and their impact on different biological models, including studies involving male and female rats. She has published 30 papers, accumulating 739 citations and maintaining an h-index of 14. Key collaborators include Volodymyr Tryndyak, Nan Mei, Xiaoqing Guo, and Xilin Li, all affiliated with the National Center for Toxicological Research.
Metrics
- h-index: 14
- Publications: 30
- Citations: 741
Selected Publications
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Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells (2021)
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Dose and temporal evaluation of ethylene oxide‐induced mutagenicity in the lungs of male big blue mice following inhalation exposure to carcinogenic concentrations (2017)
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Evaluation of <i>cII</i> gene mutation in the brains of Big Blue mice exposed to acrylamide and glycidamide in drinking water (2016)
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Evaluation of cII mutations in lung of male Big Blue mice exposed by inhalation to vanadium pentoxide for up to 8 weeks (2015)
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Acrylamide‐induced carcinogenicity in mouse lung involves mutagenicity: <i>cII</i> gene mutations in the lung of big blue mice exposed to acrylamide and glycidamide for up to 4 weeks (2015)
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Development and validation of a new transgenic hairless albino mouse as a mutational model for potential assessment of photocarcinogenicity (2015)
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Temporal Changes in K-ras Mutant Fraction in Lung Tissue of Big Blue B6C3F1 Mice Exposed to Ethylene Oxide (2013)
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In Vivo cII, gpt, and Spi− Gene Mutation Assays in Transgenic Mice and Rats (2013)
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Effects of acrylamide and glycidamide on the expression levels of hepatic mitochondria-related genes in transgenic Big Blue mice (2011)
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Mutagenicity of Acrylamide and Glycidamide in the Testes of Big Blue Mice (2010)
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Mutagenic toxicity of acrylamide and glycidamide in germ cells of mice (2009)
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Evaluation of mutagenic mode of action in Big Blue mice fed methylphenidate for 24 weeks (2009)
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Pharmacokinetics, dose‐range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice (2008)
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The genetic toxicology of methylphenidate hydrochloride in non-human primates (2008)
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Dietary effects of soy isoflavones daidzein and genistein on 7,12-dimethylbenz[a]anthracene-induced mammary mutagenesis and carcinogenesis in ovariectomized Big Blue(R) transgenic rats (2006)
Collaboration Network
Top Collaborators
- Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells
- Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells
- Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells
- Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells
- Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells
- Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells
- Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells
- Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells
- Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells
- Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells
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