Alexander J. Layman
Researcher
Also affiliated: Arkansas Children's Hospital (2023); Arkansas Department of Health (2025)
Unknown Researcher
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Alexander J. Layman's research investigates mechanisms of liver injury and protection, with a focus on the role of metabolic pathways and microRNAs. He has examined hepatic pyruvate and alanine metabolism as critical components for antioxidant capacity and resistance to oxidative stress. Layman's work also explores the role of microRNAs in cellular proliferation, specifically investigating how upregulated microRNA-21 contributes to the growth of lymphatic malformation endothelial cells by inhibiting PDCD4. He has also published on the need for increased rigor in preclinical studies of dietary supplements intended to protect against acetaminophen hepatotoxicity, and on the detection and diagnosis of hepatotoxicity in experimental and clinical settings. Layman has published four papers and has been cited 32 times, with an h-index of 2. He collaborates with researchers at the University of Arkansas for Medical Sciences, including Mitchell R. McGill, Igor Koturbash, Scott Alsbrook, and Eric U. Yee.
Metrics
- h-index: 2
- Publications: 4
- Citations: 36
Selected Publications
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Detection and Diagnosis of Hepatotoxicity in Experimental and Clinical Settings (2025)
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Natural Products That Protect Against Acetaminophen Hepatotoxicity: A Call for Increased Rigor in Preclinical Studies of Dietary Supplements (2024)
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Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult (2023)
Collaboration Network
Top Collaborators
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Natural Products That Protect Against Acetaminophen Hepatotoxicity: A Call for Increased Rigor in Preclinical Studies of Dietary Supplements
- Detection and Diagnosis of Hepatotoxicity in Experimental and Clinical Settings
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Natural Products That Protect Against Acetaminophen Hepatotoxicity: A Call for Increased Rigor in Preclinical Studies of Dietary Supplements
- Natural Products That Protect Against Acetaminophen Hepatotoxicity: A Call for Increased Rigor in Preclinical Studies of Dietary Supplements
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