Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-09-26
J
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Jacob Laster's research focuses on the regulation of bone mass and strength, specifically investigating the role of the autophagy regulator Tfeb. His work has demonstrated that increasing Tfeb expression in osteoblast lineage cells can lead to enhanced bone density and structural integrity. Laster has explored this using CRISPR activation techniques to manipulate Tfeb levels in animal models. His collaborations at the University of Arkansas for Medical Sciences include work with Melda Onal, Amy Y. Sato, A. Gordon James, and Maria Almeida, with whom he has co-authored multiple publications. Laster's scholarship is marked by a growing body of work in bone biology and cellular regulation.
Metrics
- h-index: 1
- Publications: 3
- Citations: 15
Selected Publications
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Autophagy in Osx1-Cre-targeted cells is essential for development, growth, and maintenance of bone (2026)
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Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength (2025)
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CRISPR activation of Tfeb , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength (2024)
Collaboration Network
Top Collaborators
A. Gordon James
University of Arkansas for Medical Sciences
3 shared publications
In database
- Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength
- CRISPR activation of Tfeb , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength
- Autophagy in Osx1-Cre-targeted cells is essential for development, growth, and maintenance of bone
Ilham Kadhim
University of Arkansas for Medical Sciences
3 shared publications
In database
- Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength
- CRISPR activation of Tfeb , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength
- Autophagy in Osx1-Cre-targeted cells is essential for development, growth, and maintenance of bone
Melda Onal
University of Arkansas for Medical Sciences
3 shared publications
In database
- Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength
- CRISPR activation of Tfeb , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength
- Autophagy in Osx1-Cre-targeted cells is essential for development, growth, and maintenance of bone
James A. Hendrixson
University of Arkansas for Medical Sciences
2 shared publications
In database
- Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength
- CRISPR activation of Tfeb , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength
Julie A. Crawford
University of Arkansas for Medical Sciences
2 shared publications
In database
- Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength
- CRISPR activation of Tfeb , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength
Jeff Thostenson
University of Arkansas for Medical Sciences
2 shared publications
In database
- Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength
- CRISPR activation of Tfeb , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength
Amy Y. Sato
University of Arkansas for Medical Sciences
2 shared publications
In database
- Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength
- CRISPR activation of Tfeb , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength
Maria Almeida
University of Arkansas Medical Center
2 shared publications
In database
- Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength
- CRISPR activation of Tfeb , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength
Intawat Nookaew
University of Arkansas for Medical Sciences
2 shared publications
In database
- Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength
- Autophagy in Osx1-Cre-targeted cells is essential for development, growth, and maintenance of bone
Jinhu Xiong
University of Arkansas for Medical Sciences
2 shared publications
In database
- Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength
- Autophagy in Osx1-Cre-targeted cells is essential for development, growth, and maintenance of bone
Adriana Lelis Carvalho
University of Arkansas for Medical Sciences
1 shared publication
In database
- CRISPR activation of Tfeb , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength
Visanu Wanchai
Institute of Informatics of the Slovak Academy of Sciences
1 shared publication
In database
- Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength
Vivek Khanal
University of Arkansas for Medical Sciences
1 shared publication
In database
- Autophagy in Osx1-Cre-targeted cells is essential for development, growth, and maintenance of bone
Jeff D. Thostenson
University of Arkansas for Medical Sciences
1 shared publication
In database
- Autophagy in Osx1-Cre-targeted cells is essential for development, growth, and maintenance of bone
Neha S. Dole
University of Arkansas for Medical Sciences
1 shared publication
In database
- Autophagy in Osx1-Cre-targeted cells is essential for development, growth, and maintenance of bone
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