Jin‐Ran Chen
Researcher
University of Arkansas for Medical Sciences
faculty
Research Areas
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Biography and Research Information
OverviewAI-generated summary
Jin‐Ran Chen leads a research group at the University of Arkansas for Medical Sciences that investigates mechanisms underlying bone metabolism and diseases, with a particular focus on multiple myeloma. Chen's work has explored the role of specific genes and signaling pathways in regulating osteoclastogenesis and bone resorption. Recent publications include studies on GPR109A's effect on osteoclastogenesis, CST6's suppression of osteolytic bone disease in multiple myeloma, and the impact of NEK2 expression in myeloid progenitors on T cell immunity.
Further research by Chen examines the role of Nox4 in bone development and the influence of maternal high-fat diets on offspring bone epigenetics. The group has also investigated phenolic acids for their potential to prevent bone loss and bone marrow adipogenesis. Chen's scholarship metrics include an h-index of 30, 97 total publications, and 3,322 total citations. Chen is also a principal investigator on federal grants, including a $330,316 award from the NIH/National Cancer Institute for research into novel NEK2 signaling pathways in myeloma progression. Key collaborators include Oxana P. Lazarenko, Michael L. Blackburn, Dongzheng Gai, and Fumou Sun, all from the University of Arkansas for Medical Sciences.
Metrics
- h-index: 30
- Publications: 97
- Citations: 3,322
Selected Publications
- Soy Isoflavones Prevent Bone Quality Loss Induced by High‐Fat Diet in Rats Through Epigenetic Modifications (2025) DOI
- Acetate derived from metabolism of ethanol affects gene expression in bone and contributes to delays in chondrogenic differentiation (2025) DOI
- Sex-dependent effect of GPR109A gene deletion in myeloid cells on bone development in mice (2025) DOI
- Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption (2025) DOI
- Cystatin M/E ameliorates bone resorption through increasing osteoclastic cell estrogen influx (2024) DOI
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice (2024) DOI
- High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma (2023) DOI
- A gene signature can predict risk of MGUS progressing to multiple myeloma (2023) DOI
- Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model (2023) DOI
- A Gene Signature Can Predict Risk of MGUS Progressing to Multiple Myeloma (2023) DOI
- A longitudinal observational study of skeletal development between ages 3 mo and 6 y in children fed human milk, milk formula, or soy formula (2023) DOI
- Exploring GPR109A Receptor Interaction with Hippuric Acid Using MD Simulations and CD Spectroscopy (2022) DOI
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice (2022) DOI
- Nox4 expression in osteo-progenitors controls bone development in mice during early life (2022) DOI
- GPR109A gene deletion ameliorates gonadectomy-induced bone loss in mice (2022) DOI
Federal Grants 1 $330,316 total
Grants & Funding
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