Jin‐Ran Chen

Federal Grant PI High Impact

Researcher

University of Arkansas

Last publication 2025 Last refreshed 2026-05-16

faculty

30 h-index 99 pubs 3,366 cited

Research Areas

Links

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OverviewAI-generated summary

Jin-Ran Chen's research focuses on the molecular mechanisms underlying bone metabolism and diseases, particularly in the context of conditions like multiple myeloma and osteoporosis. Chen investigates how specific genes and signaling pathways, such as NEK2 and Nox4, influence osteoclast and osteoblast function, which are critical for bone remodeling and resorption. Recent work has explored the role of GPR109A in mediating the effects of hippuric acid on osteoclastogenesis and bone resorption in mice. Another study examined how CST6 suppresses osteolytic bone disease in multiple myeloma by blocking osteoclast differentiation.

Further research by Chen delves into the impact of dietary factors and epigenetic modifications on bone health. For instance, one publication investigated how a maternal high-fat diet can alter epigenetic marks (H3K27me3 and H3K27ac) in bone to regulate offspring osteoblastogenesis. Additionally, research has explored how phenolic acids can prevent bone loss and bone marrow adipogenesis induced by sex-steroid deficiency in mice. Chen also studies the immune aspects of multiple myeloma, investigating how high NEK2 expression in myeloid progenitors suppresses T cell immunity.

Chen leads a research group and has a scholarly profile marked by 98 publications and over 3,350 citations, with an h-index of 30. This indicates a highly cited researcher. Chen has received federal funding, including a $330,316 grant from the NIH/National Cancer Institute as PI for research on novel NEK2 signaling pathways in myeloma progression. Key collaborators include researchers from the University of Arkansas for Medical Sciences and the University of Arkansas at Fayetteville.

Metrics

h-index: 30
Publications: 99
Citations: 3,366

Selected Publications

Soy Isoflavones Prevent Bone Quality Loss Induced by High‐Fat Diet in Rats Through Epigenetic Modifications (2025)

1 citation DOI OpenAlex
Soy Isoflavones Prevent Loss of Bone Quality Associated With High Fat Diet in Rats Through Ameliorating Epigenetic Modifications in Bone (2025)

DOI OpenAlex
Acetate derived from metabolism of ethanol affects gene expression in bone and contributes to delays in chondrogenic differentiation (2025)

DOI OpenAlex
Sex-dependent effect of GPR109A gene deletion in myeloid cells on bone development in mice (2025)

DOI OpenAlex
Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption (2025)

1 citation DOI OpenAlex
Cystatin M/E ameliorates bone resorption through increasing osteoclastic cell estrogen influx (2024)

DOI OpenAlex
Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice (2024)

9 citations DOI OpenAlex
High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma (2023)

17 citations DOI OpenAlex
A gene signature can predict risk of MGUS progressing to multiple myeloma (2023)

13 citations DOI OpenAlex
Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model (2023)

11 citations DOI OpenAlex
A Gene Signature Can Predict Risk of MGUS Progressing to Multiple Myeloma (2023)

DOI OpenAlex
A longitudinal observational study of skeletal development between ages 3 mo and 6 y in children fed human milk, milk formula, or soy formula (2023)

5 citations DOI OpenAlex
Exploring GPR109A Receptor Interaction with Hippuric Acid Using MD Simulations and CD Spectroscopy (2022)

6 citations DOI OpenAlex
Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice (2022)

11 citations DOI OpenAlex
Nox4 expression in osteo-progenitors controls bone development in mice during early life (2022)

16 citations DOI OpenAlex