Melanie Barker

Researcher

University of Arkansas for Medical Sciences

unknown

1 h-index 4 pubs 7 cited

Research Areas

Immune Cell Function and Interaction T-cell and B-cell Immunology DNA Repair Mechanisms Pharmacological Effects and Toxicity Studies Microbial infections and disease research Health and Medical Research Impacts

Is this your profile? Verify and claim your profile

OverviewAI-generated summary

Melanie Barker's research investigates the role of DNA-PKcs in the activation and cytotoxicity of T cells. Her work has demonstrated that chemical inhibition of DNA-PKcs impairs the function of both CD4+ helper and CD8+ effector T cells. Further studies by Barker and collaborators have shown that DNA-PKcs is specifically required for the activation and cytotoxicity of CD8+ effector T cells. Barker has also contributed to research on reducing abscess formation in a murine model of perforated appendicitis using intra-peritoneal povidone-iodine irrigation. She has published four papers, accumulating seven citations and an h-index of 1. Barker collaborates with several researchers at the University of Arkansas for Medical Sciences, including Lauren Elizabeth Appell, Ana Clara P. Azevedo‐Pouly, Brian Koss, and Lauren C. Morehead.

Metrics

  • h-index: 1
  • Publications: 4
  • Citations: 7

Selected Publications

  • Intra-peritoneal Povidone-iodine Irrigation Decreases Abscesses in a Perforated Appendicitis Murine Model (2024) DOI
  • Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells (2023) DOI
  • DNA-PKcs is required for the activation and cytotoxicity of CD8+ effector T cells (2022) DOI
  • Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells (2022) DOI

Collaborators

Researchers in the database who share publications

Lauren Elizabeth Appell University of Arkansas for Medical Sciences 3 shared publications Ana Clara P. Azevedo‐Pouly University of Arkansas for Medical Sciences 3 shared publications Brian Koss University of Arkansas for Medical Sciences 2 shared publications Lauren C. Morehead University of Arkansas for Medical Sciences 2 shared publications Lora J. Rogers University of Arkansas for Medical Sciences 2 shared publications Randall R Rainwater University of Arkansas for Medical Sciences 1 shared publication Daniel Fil University of Arkansas for Medical Sciences 1 shared publication Lindsey L. Wolf University of Arkansas for Medical Sciences 1 shared publication

Similar Researchers

Based on overlapping research topics

Juhyung Lee University of Arkansas for Medical Sciences
Immune Cell Function and Interaction T-cell and B-cell Immunology Microbial infections and disease research
Good match 3 shared topics
Hanna E. Norton Arkansas Tech University
Immune Cell Function and Interaction T-cell and B-cell Immunology Health and Medical Research Impacts
Good match 3 shared topics
Ahmed Hashoosh University of Arkansas at Little Rock
Immune Cell Function and Interaction T-cell and B-cell Immunology Health and Medical Research Impacts
Good match 3 shared topics
Jason S. Stumhofer University of Arkansas for Medical Sciences
Immune Cell Function and Interaction T-cell and B-cell Immunology Microbial infections and disease research
Good match 4 shared topics
Mayumi Nakagawa University of Arkansas for Medical Sciences
Immune Cell Function and Interaction T-cell and B-cell Immunology Microbial infections and disease research
Good match 4 shared topics
Miguel A. B. Mercado University of Arkansas for Medical Sciences
Immune Cell Function and Interaction T-cell and B-cell Immunology Microbial infections and disease research
Good match 3 shared topics