Biography and Research Information
OverviewAI-generated summary
Melanie Barker investigates the role of DNA-PKcs in immune cell function and explores potential therapeutic interventions. Her recent work focuses on the chemical inhibition of DNA-PKcs and its impact on the activation and cytotoxicity of CD4+ helper and CD8+ effector T cells. Barker also studies the efficacy of local anti-infective agents, specifically examining the use of intra-peritoneal povidone-iodine irrigation to decrease abscess formation in a murine model of perforated appendicitis. Her research network includes collaborators at the University of Arkansas for Medical Sciences, such as Lauren Appell, Ana Clara P. Azevedo‐Pouly, and Lyle Burdine, with whom she has co-authored multiple publications. Barker's scholarship metrics include an h-index of 1, with 4 total publications and 7 total citations.
Metrics
- h-index: 2
- Publications: 4
- Citations: 8
Selected Publications
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Intra-peritoneal Povidone-iodine Irrigation Decreases Abscesses in a Perforated Appendicitis Murine Model (2024)
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Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells (2023)
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DNA-PKcs is required for the activation and cytotoxicity of CD8+ effector T cells (2022)
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Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells (2022)
Collaboration Network
Top Collaborators
Zachary J. Waldrip
University of Arkansas for Medical Sciences (US)
4 shared publications
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Intra-peritoneal Povidone-iodine Irrigation Decreases Abscesses in a Perforated Appendicitis Murine Model
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells
- DNA-PKcs is required for the activation and cytotoxicity of CD8+ effector T cells
Marie Burdine
University of Arkansas for Medical Sciences (US)
4 shared publications
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Intra-peritoneal Povidone-iodine Irrigation Decreases Abscesses in a Perforated Appendicitis Murine Model
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells
- DNA-PKcs is required for the activation and cytotoxicity of CD8+ effector T cells
Ana Clara P. Azevedo‐Pouly
University of Arkansas for Medical Sciences
3 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells
- DNA-PKcs is required for the activation and cytotoxicity of CD8+ effector T cells
Lauren Appell
Arkansas Children's Hospital
3 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells
- DNA-PKcs is required for the activation and cytotoxicity of CD8+ effector T cells
Lyle Burdine
University of Arkansas for Medical Sciences (US)
3 shared publications
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells
- DNA-PKcs is required for the activation and cytotoxicity of CD8+ effector T cells
Lora J. Rogers
University of Arkansas for Medical Sciences
2 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells
Lauren C. Morehead
University of Arkansas for Medical Sciences
2 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells
Brian Koss
University of Arkansas for Medical Sciences
2 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells
Daniel Fil
University of Arkansas for Medical Sciences
1 shared publication
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
Randall R Rainwater
University of Arkansas for Medical Sciences
1 shared publication
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
Derek Krinock
1 shared publication
In database
- Intra-peritoneal Povidone-iodine Irrigation Decreases Abscesses in a Perforated Appendicitis Murine Model
Krista Stephenson
University of Arkansas for Medical Sciences (US)
1 shared publication
- Intra-peritoneal Povidone-iodine Irrigation Decreases Abscesses in a Perforated Appendicitis Murine Model
David Irby
University of Arkansas for Medical Sciences
1 shared publication
In database
- Intra-peritoneal Povidone-iodine Irrigation Decreases Abscesses in a Perforated Appendicitis Murine Model
Chary Akmyradov
Arkansas Children's Hospital
1 shared publication
In database
- Intra-peritoneal Povidone-iodine Irrigation Decreases Abscesses in a Perforated Appendicitis Murine Model
Lindsey L. Wolf
Arkansas Children's Hospital
1 shared publication
In database
- Intra-peritoneal Povidone-iodine Irrigation Decreases Abscesses in a Perforated Appendicitis Murine Model
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