M
Murat Gökden
Federal Grant PI
High Impact
Professor
faculty
Pathology, College of Medicine
27 h-index
163 pubs
2,929 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Murat Gökden, Professor of Pathology at the University of Arkansas for Medical Sciences, studies the molecular and cellular mechanisms underlying central nervous system (CNS) tumors. His research group is focused on developing and applying advanced diagnostic and therapeutic strategies for these complex diseases. This work includes the clinical utility of whole-genome DNA methylation profiling as a primary molecular diagnostic assay for CNS tumors and the development of functional precision medicine pipelines that combine comparative transcriptomics with tumor organoid modeling to identify bespoke treatment strategies for glioblastoma.
Dr. Gökden's research also investigates the cellular lineages and gene expression patterns of specific tumor types, such as astroblastomas. His work has been supported by federal grants from the National Institutes of Health (NIH), including funding for immunotherapy mechanisms in ovarian cancer and the role of platelets in radiation-induced immune dysregulation. He has published extensively, with a notable body of work on brain tumors, and holds certifications in Anatomic Pathology, Neuropathology, and Cytopathology. His scholarship metrics include an h-index of 27, 156 total publications, and 2,900 total citations.
Research Overview
Academic Appointment • Professor of Pathology Department - Pathology Education • Fellowship: Cytopathology-University of Arkansas for Medical Sciences • Fellowship: Surgical Pathology-University of Texas, MD Anderson Cancer Center • Fellowship: Neuropathology-Washington University in St. Louis • Residency: Anatomic Pathology- Washington University in St. Louis • Medical School: Dokuz Eylul Medical School, Izmir, Turkey Professional Certifications • American Board of Pathology-Anatomic Pathology • American Board of Pathology-Neuropathology • American Board of Pathology-Cytopathology
Metrics
- h-index: 27
- Publications: 163
- Citations: 2,929
Selected Publications
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Pathologic Variability Associated With Phenotypic Differences in Siblings With <scp>ACTA1</scp> Myopathy (2026)
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Illuminating Blurry Vision: Visualization of Corneal Protein Deposition With Immunofluorescence in Two Illustrative Case Reports (2026)
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Can Transcutaneous Vagus Nerve Stimulation be Effective After Rats’ Spinal Cord Injury? (2026)
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Intracranial mesenchymal tumor, FET::CREB fusion-positive: An integrative analysis of 81 cases (2026)
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Targeted Inhibition in Pediatric MET and ALK-Altered Hemispheric Gliomas: Objective Responses Followed by Treatment Resistance (2025)
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Signal Recognition Particle Myopathy With Cardiac Manifestations in Rheumatoid Arthritis (2025)
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Surgery of peritorcular meningiomas: the structural basis for preservation of torcular venous flow (2025)
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Navigating molecular neuropathology of CNS neoplasms for the practicing surgical pathologist (2025)
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Can Transcutaneous Vagus Nerve Stimulation Be Effective after Rats’ Spinal Cord Injury? (2025)
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A rare presentation of pediatric germinoma mimicking optic pathway glioma: illustrative case (2025)
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Large B-cell Lymphoma With Interferon Regulatory Factor 4 Rearrangement Presenting as a Primary Central Nervous System Lymphoma in the Brain (2025)
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Unusual Presentation and Rare Location of Enterogenous Cyst in the Cerebellopontine Angle: Two Cases and Review of the Literature (2025)
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A novel rotation and scale-invariant deep learning framework leveraging conical transformers for precise differentiation between meningioma and solitary fibrous tumor (2025)
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Letter to the Editor Regarding “An Extremely Rare Case of Collision Tumor: A Craniopharyngioma Coexists Pilocytic Astrocytoma” (2025)
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Unexpected Presentations of Histiocytic Disorders as Mass Lesions in the Central Nervous System and Spine (2024)
Federal Grants 2 $872,121 total
NIH/National Cancer Institute
Contact PI
Mar 2024 - Feb 2027
NIH/NIH Office of the Director
Co-PI
Jul 2022 - May 2027
Grants & Funding
- Early Events in Alzheimer Pathogenesis NIH Co-Investigator
Collaboration Network
Top Collaborators
Analiz Rodriguez
University of Arkansas for Medical Sciences
11 shared publications
In database
- A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma
- Brain Tumor Biobank Development for Precision Medicine: Role of the Neurosurgeon
- Genomic and Transcriptomic Profiling of Brain Metastases
- Primary glioblastoma of the cauda equina with molecular and histopathological characterization: Case report
- SMARCA4-deficient central nervous system metastases: A case series and systematic review
Showing 5 of 11 shared publications
J. Stephen Nix
8 shared publications
In database
- Significance of Staining Intensity in Ki-67 Proliferation Index in Meningiomas, and a Critical Review of the Literature on Proliferation Index Assessment.
- SMARCA4-deficient central nervous system metastases: A case series and systematic review
- Miyoshi Muscular Dystrophy Due to Novel Splice Site Variants in <i>DYSF</i> Gene
- Operative planning for a functional precision medicine assay of recurrent high-grade glioma: illustrative case
- A rare case of atypical intradural extramedullary glioblastoma diagnosed utilizing next-generation sequencing and methylation profiling: illustrative case
Showing 5 of 8 shared publications
Kevin Bielamowicz
University of Arkansas Medical Center
7 shared publications
In database
- Central nervous system embryonal tumors with EWSR1-PLAGL1 rearrangements reclassified as INI-1 deficient tumors at relapse
- Targeted Inhibition in Pediatric MET and ALK-Altered Hemispheric Gliomas: Objective Responses Followed by Treatment Resistance
- ETMR-15. Central Nervous System Embryonal Tumor with EWSR1 translocation: Evolving changes in histology, sequencing, and epigenetics at relapse in 2 patients and potential treatment implications
- EXTH-77. INFANT-TYPE HEMISPHERIC GLIOMAS WITH INITIAL RESPONSE FOLLOWED BY RESISTANCE ON TARGETED AGENTS
- A rare presentation of pediatric germinoma mimicking optic pathway glioma: illustrative case
Showing 5 of 7 shared publications
Christopher P. Wardell
University of Arkansas for Medical Sciences
5 shared publications
In database
- A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma
- Genomic and Transcriptomic Profiling of Brain Metastases
- Primary glioblastoma of the cauda equina with molecular and histopathological characterization: Case report
- Long-read sequencing for brain tumors
- Intracranial hematolymphoid malignancies: A case series with molecular characterization
Sateesh Jayappa
Arkansas Children's Hospital
5 shared publications
In database
- Central nervous system embryonal tumors with EWSR1-PLAGL1 rearrangements reclassified as INI-1 deficient tumors at relapse
- Targeted Inhibition in Pediatric MET and ALK-Altered Hemispheric Gliomas: Objective Responses Followed by Treatment Resistance
- ETMR-15. Central Nervous System Embryonal Tumor with EWSR1 translocation: Evolving changes in histology, sequencing, and epigenetics at relapse in 2 patients and potential treatment implications
- EXTH-77. INFANT-TYPE HEMISPHERIC GLIOMAS WITH INITIAL RESPONSE FOLLOWED BY RESISTANCE ON TARGETED AGENTS
- TARGETED INHIBITION IN PEDIATRIC MET and ALK ALTERED PEDIATRIC HIGH GRADE GLIOMAS: OBJECTIVE RESPONSES FOLLOWED BY TREATMENT RESISTANCE
Erika Horta
University of Arkansas for Medical Sciences
5 shared publications
In database
- Diffuse Leptomeningeal Glioneuronal Tumor: First Description of Metastasis to the Lung and Bone Marrow
- Operative planning for a functional precision medicine assay of recurrent high-grade glioma: illustrative case
- Functional precision medicine assay for recurrent meningioma: a proof of principle. Illustrative case
- NCMP-15. A CASE OF SYSTEMIC METASTATIC DIFFUSE LEPTOMENINGEAL GLIONEURAL TUMOR
- Navigating molecular neuropathology of CNS neoplasms for the practicing surgical pathologist
Rohan Sharma
Neurology, Inc (US)
4 shared publications
- Spectrum of Hemorrhagic Encephalitis in COVID-19 Patients: A Case Series and Review
- CD8 Encephalitis: A Diagnostic Dilemma
- Spectrum of Acute Necrotizing Hemorrhagic Encephalitis in COVID-19 patients: A case series and Review (P1-1.Virtual)
- IG4 Disease Presenting as Chronic Headaches (P7-14.015)
Nidhi Kapoor
Neurology, Inc (US)
4 shared publications
- Spectrum of Hemorrhagic Encephalitis in COVID-19 Patients: A Case Series and Review
- CD8 Encephalitis: A Diagnostic Dilemma
- Spectrum of Acute Necrotizing Hemorrhagic Encephalitis in COVID-19 patients: A case series and Review (P1-1.Virtual)
- IG4 Disease Presenting as Chronic Headaches (P7-14.015)
William J. Shelton
University of Arkansas for Medical Sciences
4 shared publications
In database
- Operative planning for a functional precision medicine assay of recurrent high-grade glioma: illustrative case
- A rare case of atypical intradural extramedullary glioblastoma diagnosed utilizing next-generation sequencing and methylation profiling: illustrative case
- Long-read sequencing for brain tumors
- Functional precision medicine assay for recurrent meningioma: a proof of principle. Illustrative case
Hannah Cutshall
University of Arkansas for Medical Sciences
4 shared publications
In database
- SMARCA4-deficient central nervous system metastases: A case series and systematic review
- Large B-cell Lymphoma With Interferon Regulatory Factor 4 Rearrangement Presenting as a Primary Central Nervous System Lymphoma in the Brain
- Brain Autopsy Findings in a Patient Who Received Lipid Emulsion Therapy for Suspected Drug Intoxication
- Unexpected Presentations of Histiocytic Disorders as Mass Lesions in the Central Nervous System and Spine
Lora Parker
Arkansas Children's Hospital (US)
4 shared publications
- Central nervous system embryonal tumors with EWSR1-PLAGL1 rearrangements reclassified as INI-1 deficient tumors at relapse
- Targeted Inhibition in Pediatric MET and ALK-Altered Hemispheric Gliomas: Objective Responses Followed by Treatment Resistance
- EXTH-77. INFANT-TYPE HEMISPHERIC GLIOMAS WITH INITIAL RESPONSE FOLLOWED BY RESISTANCE ON TARGETED AGENTS
- TARGETED INHIBITION IN PEDIATRIC MET and ALK ALTERED PEDIATRIC HIGH GRADE GLIOMAS: OBJECTIVE RESPONSES FOLLOWED BY TREATMENT RESISTANCE
Tomoko Tanaka
University of Arkansas for Medical Sciences (US)
4 shared publications
- Targeted Inhibition in Pediatric MET and ALK-Altered Hemispheric Gliomas: Objective Responses Followed by Treatment Resistance
- EXTH-77. INFANT-TYPE HEMISPHERIC GLIOMAS WITH INITIAL RESPONSE FOLLOWED BY RESISTANCE ON TARGETED AGENTS
- Can Transcutaneous Vagus Nerve Stimulation Be Effective after Rats’ Spinal Cord Injury?
- TARGETED INHIBITION IN PEDIATRIC MET and ALK ALTERED PEDIATRIC HIGH GRADE GLIOMAS: OBJECTIVE RESPONSES FOLLOWED BY TREATMENT RESISTANCE
Annick De Loose
University of Arkansas for Medical Sciences
3 shared publications
In database
- A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma
- Brain Tumor Biobank Development for Precision Medicine: Role of the Neurosurgeon
- Genomic and Transcriptomic Profiling of Brain Metastases
Madison P. Lee
University of Arkansas for Medical Sciences
3 shared publications
In database
- A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma
- Brain Tumor Biobank Development for Precision Medicine: Role of the Neurosurgeon
- Genomic and Transcriptomic Profiling of Brain Metastases
John Day
University of Arkansas for Medical Sciences (US)
3 shared publications
- Brain Tumor Biobank Development for Precision Medicine: Role of the Neurosurgeon
- Primary histiocytic sarcoma of the clivus with focal extension into central nervous system and neurologic manifestations: First description at an unusual site with an overwhelming and rapid progression
- Intracranial hematolymphoid malignancies: A case series with molecular characterization
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