Nancy J. Rusch

High Impact

Distinguished Professor

UAMS

Last publication 2026 Last refreshed 2026-05-23

faculty

College of Medicine

42 h-index 194 pubs 5,000 cited

Research Areas

Links

ORCID Google Scholar Lab Website Research Group UAMS TRI Profile

OverviewAI-generated summary

Nancy J. Rusch, Distinguished Professor in the College of Medicine at the University of Arkansas for Medical Sciences, studies the role of myeloid cells in various disease states, including ischemic retinopathies and vascular aging. Her research investigates how these cells, particularly macrophages, influence disease progression and potential therapeutic interventions.

Recent work by Rusch and her collaborators has focused on the mechanisms by which myeloid cell function impacts inflammatory responses and tissue injury. This includes exploring pathways involving histone deacetylase 3 (HDAC3) and the arginase 1/ornithine decarboxylase pathway in the context of retinal ischemic injury. Her group also examines the role of endothelial cells in mediating inflammatory processes and their potential macrophage-like functions.

Further research interests include the mechanisms underlying drug-induced lymphedema and potential therapeutic strategies, as demonstrated by studies on dantrolene's effects in preventing doxorubicin-induced lymphostasis. Rusch also investigates the complex signaling pathways involved in conditions such as hepatocellular carcinoma, exploring epigenetic dysregulation and its impact on cellular signaling. Her scholarship metrics include an h-index of 42, 192 total publications, and 4,950 total citations.

Metrics

h-index: 42
Publications: 194
Citations: 5,000

Selected Publications

Nanoencapsulated gamma-oryzanol enhances fibroblast proliferation, migration, and reduces oxidative stress in H2O2-induced cellular aging model (2025)

DOI OpenAlex
HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis (2025)

DOI OpenAlex
The role of efferocytosis in ischemic stroke and insights from retinopathy (2025)

DOI OpenAlex
Rhythmic Contractions of Lymph Vessels and Lymph Flow Are Disrupted in Hypertensive Rats (2024)

DOI OpenAlex
Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury (2024)

14 citations DOI OpenAlex
The Loss of an Orphan Nuclear Receptor NR2E3 Augments Wnt/β‐catenin Signaling via Epigenetic Dysregulation that Enhances Sp1‐β catenin‐p300 Interactions in Hepatocellular Carcinoma (2024)

8 citations DOI OpenAlex
SS-31 Attenuates Doxorubicin-induced Cardiomyoblast H9C2 Cell Senescence (2024)

DOI OpenAlex
Abstract 3011: The loss of an orphan nuclear receptor NR2E3 augments Wnt/β-Catenin signaling via epigenetic dysregulation that links to the Sp1-β catenin-p300 interactions in hepatocellular carcinoma (2024)

DOI OpenAlex
Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions (2024)

43 citations DOI OpenAlex
The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury (2023)

25 citations DOI OpenAlex
PCSK9 attenuates efferocytosis in endothelial cells and promotes vascular aging (2023)

50 citations DOI OpenAlex
Mitochondrial proton leak in cardiac aging (2023)

6 citations DOI OpenAlex
Opinion: Endothelial Cells - Macrophage-Like Gatekeepers? (2022)

16 citations DOI OpenAlex
Drug-Related Lymphedema: Mysteries, Mechanisms, and Potential Therapies (2022)

30 citations DOI OpenAlex
Dantrolene Prevents the Lymphostasis Caused by Doxorubicin in the Rat Mesenteric Circulation (2021)

18 citations DOI OpenAlex

View all publications on OpenAlex →

Grants & Funding

MicroRNA to decrease vascular CaV1.2 in hypertension NIH Co-Investigator
AHA-Vascular TRPC3 Channels as Antihypertensive Targets American Heart Association (SouthWest Affiliate) Principal Investigator
Beta adrenergic receptor-mediated vasodilation of cerebral collateral arteries- Resubmission- Resubmission American Heart Association Principal Investigator
T32 Campus Match funding Account UAMS College of Medicine Principal Investigator
Pharmacology Dept GEF Account UAMS College of Medicine Principal Investigator
Long-term Antihypertensive Therapy by Delivery of the BK Channel Gene to VSMCs NIH Principal Investigator
Role of mitoBK channels in rat renal cold preservation American Heart Association (SouthWest Affiliate) Principal Investigator
Role of Cerebrovascular K+ Channels in Hypertension NIH Principal Investigator