Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
Samuel G. Mackintosh
High Impact
Professor
Also affiliated: University of North Carolina at Chapel Hill (2020); University of Rome Tor Vergata (2016); University of California, Los Angeles (2022); University of Arkansas Medical Center (2015–2020); University of Arkansas System (2020–2022); Central Arkansas Veterans Healthcare System (2016); UCLA Jonsson Comprehensive Cancer Center (2022); Arkansas Children's Research Institute (2024)
Biochemistry & Molecular Biology, College of Medicine
37 h-index
153 pubs
4,753 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Samuel G. Mackintosh serves as Professor in Biochemistry & Molecular Biology at the University of Arkansas for Medical Sciences. He has extensive experience, spanning nearly two decades, in the operation and maintenance of nanoflow liquid chromatography mass spectrometry (MS) instrument systems, including various Thermo Orbitrap models. As Managing Director of the IDeA National Resource for Quantitative Proteomics and Co-Director of the UAMS WP Rockefeller Cancer Institute Proteomics Shared Resource, Mackintosh collaborates with principal investigators to apply MS technology to diverse research projects.
His work involves planning research, preparing biological samples for MS analysis, operating and maintaining HPLC and MS instruments, and analyzing MS data. He routinely uses software such as Mascot, MaxQuant, Scaffold, and Spectronaut for data analysis. In the past five years, nearly 50 publications from users of the IDeA National Resource for Quantitative Proteomics have incorporated data generated in his facility. Mackintosh has a strong record of collaboration, with numerous shared publications with colleagues at the University of Arkansas for Medical Sciences, including Ricky D. Edmondson, Stephanie D. Byrum, Alan J. Tackett, and Aaron J. Storey. His scholarly output is recognized by an h-index of 37 and over 4,700 citations across 153 publications.
Metrics
- h-index: 37
- Publications: 153
- Citations: 4,753
Positions
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Professor 2006–presentUniversity of Arkansas for Medical Sciences Biochemistry & Molecular Biology, College of Medicine Institutional directory
Selected Publications
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Human gastric extracellular matrix hydrogels maintain organoid growth and reduce gene expression associated with stemness and inflammation (2026)
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Effect of complement 3/5 knockout on renal proteomics landscape after ischemia and reperfusion injury in rats (2026)
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Additional file 2 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 2 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 3 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 5 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 5 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 1 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 4 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 3 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 1 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 4 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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A method utilizing chemical carcinogens and a Western diet to reliably induce advanced hepatocellular carcinoma in male and female mice (2026)
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Abstract 6079: Resistance-specific proteogenomics in melanoma PDXs (2026)
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A new chemical carcinogen and Western diet protocol to reliably induce advanced hepatocellular carcinoma in male and female mice (2026)
Grants & Funding
As listed on this researcher's institutional profile.
- HCV NS3: Biological, Biochemical and Structural Analysis NIH Co-Investigator
- Single molecule nucleic acid enzymology NIH Co-Investigator
- Orbitrap Fusion Tribrid Mass Spectrometer NIH Principal Investigator
- Q Exactive HF-X Hybrid Quadrupole Orbitrap Mass Spectrometer NIH/Office of the Director Principal Investigator
- Q Exactive HF-X Hybrid Quadrupole Orbitrap Mass Spectrometer NIH Principal Investigator
- IDeA National Resource for Quantitative Proteomics NIH Co-Investigator
Collaboration Network
Top Collaborators
Stephanie D. Byrum
University of Arkansas for Medical Sciences
75 shared publications
In database
- DNA methylation on N6-adenine in mammalian embryonic stem cells
- Phase separation drives aberrant chromatin looping and cancer development
- ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth
- A CRISPR-based approach for proteomic analysis of a single genomic locus
- Indicators of responsiveness to immune checkpoint inhibitors
Showing 5 of 75 shared publications
Alan J. Tackett
University of Arkansas for Medical Sciences
69 shared publications
In database
- DNA methylation on N6-adenine in mammalian embryonic stem cells
- Phase separation drives aberrant chromatin looping and cancer development
- ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth
- Oxidation resistance 1 is a novel senolytic target
- A CRISPR-based approach for proteomic analysis of a single genomic locus
Showing 5 of 69 shared publications
Aaron J. Storey
University of Arkansas for Medical Sciences
40 shared publications
In database
- Phase separation drives aberrant chromatin looping and cancer development
- A CRISPR-based approach for proteomic analysis of a single genomic locus
- PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
Showing 5 of 40 shared publications
Rick D. Edmondson
University of Arkansas for Medical Sciences
29 shared publications
In database
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- ProteoViz: a tool for the analysis and interactive visualization of phosphoproteomics data
- Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Exploiting Correlations between Protein Abundance and the Functional Status of saeRS and sarA To Identify Virulence Factors of Potential Importance in the Pathogenesis of Staphylococcus aureus Osteomyelitis
Showing 5 of 29 shared publications
Ricky D. Edmondson
University of Arkansas for Medical Sciences
22 shared publications
In database
- Phase separation drives aberrant chromatin looping and cancer development
- Microalbuminuria in Type 1 Diabetes Is Associated With Enhanced Excretion of the Endocytic Multiligand Receptors Megalin and Cubilin
- Indicators of responsiveness to immune checkpoint inhibitors
- PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
Showing 5 of 22 shared publications
Gang Greg Wang
Duke University (US)
15 shared publications
- Phase separation drives aberrant chromatin looping and cancer development
- PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
Showing 5 of 15 shared publications
Wayne P. Wahls
University of Arkansas for Medical Sciences
14 shared publications
In database
- A CRISPR-based approach for proteomic analysis of a single genomic locus
- Accurate and Sensitive Quantitation of the Dynamic Heat Shock Proteome Using Tandem Mass Tags
- Dynamic global acetylation remodeling during the yeast heat shock response
- Accurate and Sensitive Quantitation of the Dynamic Heat Shock Proteome using Tandem Mass Tags
- Additional file 4 of Dynamic global acetylation remodeling during the yeast heat shock response
Showing 5 of 14 shared publications
Charity L. Washam
University of Arkansas for Medical Sciences
14 shared publications
In database
- ProteoViz: a tool for the analysis and interactive visualization of phosphoproteomics data
- Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Exploiting Correlations between Protein Abundance and the Functional Status of saeRS and sarA To Identify Virulence Factors of Potential Importance in the Pathogenesis of Staphylococcus aureus Osteomyelitis
- Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells
- PHF19 inhibition as a therapeutic target in multiple myeloma
Showing 5 of 14 shared publications
Jeffrey A. Lewis
University of Arkansas at Fayetteville
13 shared publications
In database
- Accurate and Sensitive Quantitation of the Dynamic Heat Shock Proteome Using Tandem Mass Tags
- Dynamic global acetylation remodeling during the yeast heat shock response
- Accurate and Sensitive Quantitation of the Dynamic Heat Shock Proteome using Tandem Mass Tags
- Additional file 4 of Dynamic global acetylation remodeling during the yeast heat shock response
- Additional file 1 of Dynamic global acetylation remodeling during the yeast heat shock response
Showing 5 of 13 shared publications
Ling Cai
Duke University (US)
13 shared publications
- Phase separation drives aberrant chromatin looping and cancer development
- PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
Showing 5 of 13 shared publications
Brian Koss
University of Arkansas for Medical Sciences
11 shared publications
In database
- Indicators of responsiveness to immune checkpoint inhibitors
- PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation
- Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma
- Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Proteomic signatures of innate immunity in immunotherapy naïve melanomas correlate with anti-CTLA-4 immunotherapy responsiveness
Showing 5 of 11 shared publications
Rebecca E. Hardman-Kavanaugh
University of Arkansas at Fayetteville
11 shared publications
In database
- Dynamic global acetylation remodeling during the yeast heat shock response
- Additional file 4 of Dynamic global acetylation remodeling during the yeast heat shock response
- Additional file 1 of Dynamic global acetylation remodeling during the yeast heat shock response
- Additional file 3 of Dynamic global acetylation remodeling during the yeast heat shock response
- Additional file 4 of Dynamic global acetylation remodeling during the yeast heat shock response
Showing 5 of 11 shared publications
Tara Stuecker
University of Arkansas at Fayetteville
11 shared publications
In database
- Dynamic global acetylation remodeling during the yeast heat shock response
- Additional file 4 of Dynamic global acetylation remodeling during the yeast heat shock response
- Additional file 1 of Dynamic global acetylation remodeling during the yeast heat shock response
- Additional file 3 of Dynamic global acetylation remodeling during the yeast heat shock response
- Additional file 4 of Dynamic global acetylation remodeling during the yeast heat shock response
Showing 5 of 11 shared publications
Stephanie E. Hood
University of Arkansas at Fayetteville
11 shared publications
In database
- Dynamic global acetylation remodeling during the yeast heat shock response
- Additional file 4 of Dynamic global acetylation remodeling during the yeast heat shock response
- Additional file 1 of Dynamic global acetylation remodeling during the yeast heat shock response
- Additional file 3 of Dynamic global acetylation remodeling during the yeast heat shock response
- Additional file 4 of Dynamic global acetylation remodeling during the yeast heat shock response
Showing 5 of 11 shared publications
Gregory A. Barrett-Wilt
University of Wisconsin System (US)
10 shared publications
- Additional file 4 of Dynamic global acetylation remodeling during the yeast heat shock response
- Additional file 1 of Dynamic global acetylation remodeling during the yeast heat shock response
- Additional file 3 of Dynamic global acetylation remodeling during the yeast heat shock response
- Additional file 4 of Dynamic global acetylation remodeling during the yeast heat shock response
- Additional file 1 of Dynamic global acetylation remodeling during the yeast heat shock response
Showing 5 of 10 shared publications
Similar Researchers
Based on overlapping research topics
Charity L. Washam
University of Arkansas for Medical Sciences
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Stephanie D. Byrum
University of Arkansas for Medical Sciences
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