Samuel G. Mackintosh
High Impact
Professor
faculty
Biochemistry & Molecular Biology, College of Medicine
37 h-index
146 pubs
4,532 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Samuel G. Mackintosh's research group at the University of Arkansas for Medical Sciences focuses on understanding the molecular mechanisms underlying cancer development and exploring potential therapeutic strategies. His work investigates how phase separation contributes to aberrant chromatin looping in cancer and the development of targeted protein degradation techniques, such as PROTACs (proteolysis-targeting chimeras), to suppress oncogenic nodes and degrade specific proteins like NSD3 and cMyc.
His team also studies the role of specific proteins and signaling pathways in cancer progression. This includes examining the function of CDK8 and CDK19 as regulators of signal-induced transcription, the involvement of transcription factors like YY1 in tumorigenesis, and the engagement of histone modifications, such as H3K9me3, in silencing endogenous retrotransposons. Additionally, research extends to the interplay between cellular processes like iron uptake and mitochondrial function in regulating bone mass, with implications for diseases affecting bone health.
Mackintosh leads a research group and has a significant publication record, with 140 total publications and an h-index of 36. He has collaborated extensively with researchers at the University of Arkansas for Medical Sciences, including Alan J. Tackett (23 shared publications), Aaron J. Storey (19 shared publications), Dr. Stephanie Byrum (18 shared publications), and Rick D. Edmondson (12 shared publications). His work is recognized as high-impact, evidenced by numerous citations and his designation as a highly cited researcher.
Metrics
- h-index: 37
- Publications: 146
- Citations: 4,532
Selected Publications
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277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion (2025)
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Multicellular tumor-stromal interactions recapitulate aspects of therapeutic response and human oncogenic signaling in a 3D disease model for H3K27M-altered DIPG (2025)
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BAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication (2025)
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Protective effects of factor XI inhibition by abelacimab in a baboon model of live Staphylococcus aureus sepsis (2025)
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<i>BRCA1</i> influences whole body metabolism in humanized mice (2025)
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The phenylalanine-and-glycine repeats of NUP98 oncofusions form condensates that selectively partition transcriptional coactivators (2025)
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Staphylococcus aureus Proteins Implicated in the Reduced Virulence of sarA and sarA/agr Mutants in Osteomyelitis (2025)
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Dynamic global acetylation remodeling during the yeast heat shock response (2025)
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Cold Storage Disrupts the Proteome and Phosphoproteome Landscape in Rat Kidney Transplants (2024)
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Quantitative analysis of septin Cdc10 & Cdc3-associated proteome during stress response in the fungal pathogen Cryptococcus neoformans (2024)
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319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion (2024)
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Quantitative plasma proteomic analysis in children after superior cavopulmonary anastomosis with pulmonary arteriovenous malformations (2024)
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Klotho enhances diastolic function in aged hearts through Sirt1-mediated pathways (2024)
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Chromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses (2024)
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TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons (2023)
Grants & Funding
- HCV NS3: Biological, Biochemical and Structural Analysis NIH Co-Investigator
- Single molecule nucleic acid enzymology NIH Co-Investigator
- Orbitrap Fusion Tribrid Mass Spectrometer NIH Principal Investigator
- Q Exactive HF-X Hybrid Quadrupole Orbitrap Mass Spectrometer NIH/Office of the Director Principal Investigator
- Q Exactive HF-X Hybrid Quadrupole Orbitrap Mass Spectrometer NIH Principal Investigator
- IDeA National Resource for Quantitative Proteomics NIH Co-Investigator
Collaboration Network
Top Collaborators
Stephanie D. Byrum
University of Arkansas for Medical Sciences
35 shared publications
In database
- Phase separation drives aberrant chromatin looping and cancer development
- CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
Showing 5 of 35 shared publications
Alan J. Tackett
University of Arkansas for Medical Sciences
23 shared publications
In database
- Phase separation drives aberrant chromatin looping and cancer development
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
Showing 5 of 23 shared publications
Aaron J. Storey
University of Arkansas for Medical Sciences
18 shared publications
In database
- Phase separation drives aberrant chromatin looping and cancer development
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
Showing 5 of 18 shared publications
Ricky D. Edmondson
University of Arkansas for Medical Sciences
12 shared publications
In database
- Phase separation drives aberrant chromatin looping and cancer development
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
Showing 5 of 12 shared publications
Gang Greg Wang
11 shared publications
- Phase separation drives aberrant chromatin looping and cancer development
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
Showing 5 of 11 shared publications
Ling Cai
Duke University (US)
10 shared publications
- Phase separation drives aberrant chromatin looping and cancer development
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
Showing 5 of 10 shared publications
Charity L. Washam
University of Arkansas for Medical Sciences
9 shared publications
In database
- Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells
- PHF19 inhibition as a therapeutic target in multiple myeloma
- Cold Storage Disrupts the Proteome and Phosphoproteome Landscape in Rat Kidney Transplants
- Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle
- Proteogenomics analysis to identify acquired resistance-specific alterations in melanoma PDXs on MAPKi therapy
Showing 5 of 9 shared publications
Rick D. Edmondson
University of Arkansas for Medical Sciences (US)
8 shared publications
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- Characterization of methionine dependence in melanoma cells
- Staphylococcus aureus Proteins Implicated in the Reduced Virulence of sarA and sarA/agr Mutants in Osteomyelitis
- Characterization of methionine dependence in melanoma cells
Showing 5 of 8 shared publications
Weida Gong
University of North Carolina at Chapel Hill (US)
6 shared publications
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
Showing 5 of 6 shared publications
Yi‐Hsuan Tsai
University of North Carolina at Chapel Hill (US)
6 shared publications
- Phase separation drives aberrant chromatin looping and cancer development
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
Showing 5 of 6 shared publications
Yiran Guo
Duke University (US)
6 shared publications
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
- The phenylalanine-and-glycine repeats of NUP98 oncofusions form condensates that selectively partition transcriptional coactivators
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
Showing 5 of 6 shared publications
Renny S. Lan
Arkansas Children's Nutrition Center
5 shared publications
In database
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Klotho enhances diastolic function in aged hearts through Sirt1-mediated pathways
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Author response: Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle
Stephanie D. Byrum
St. Jude Children's Research Hospital (US)
5 shared publications
- Protective effects of factor XI inhibition by abelacimab in a baboon model of live Staphylococcus aureus sepsis
- Multicellular tumor-stromal interactions recapitulate aspects of therapeutic response and human oncogenic signaling in a 3D disease model for H3K27M-altered DIPG
- Cold Storage Disrupts the Proteome and Phosphoproteome Landscape in Rat Kidney Transplants
- <i>BRCA1</i> influences whole body metabolism in humanized mice
- Proteomics Indicates Lactate Dehydrogenase is Prognostic in Acetaminophen-induced Acute Liver Failure Patients and Reveals a Role for LKB1-AMPK Signaling
Nathan L. Avaritt
University of Arkansas for Medical Sciences
5 shared publications
In database
- Protective effects of factor XI inhibition by abelacimab in a baboon model of live Staphylococcus aureus sepsis
- Proteogenomics analysis to identify acquired resistance-specific alterations in melanoma PDXs on MAPKi therapy
- Proteogenomics Reference Database Protocol v1
- Proteogenomics Reference Database Protocol v1
- Proteogenomics Analysis to Identify Acquired Resistance-Specific Alterations in Melanoma PDXs on MAPKi Therapy
Allen Gies
University of Arkansas for Medical Sciences
5 shared publications
In database
- Characterization of methionine dependence in melanoma cells
- Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells
- Targeting mitochondria in the aged cerebral vasculature with SS-31, a proteomic study of brain microvessels
- Characterization of methionine dependence in melanoma cells
- Data from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
Similar Researchers
Based on overlapping research topics
Pamela Lockyer
University of Arkansas for Medical Sciences
Cancer-related molecular mechanisms research
Protein Degradation and Inhibitors
Epigenetics and DNA Methylation
Alan J. Tackett
University of Arkansas for Medical Sciences
Cancer-related molecular mechanisms research
Protein Degradation and Inhibitors
Epigenetics and DNA Methylation
Aaron J. Storey
University of Arkansas for Medical Sciences
Cancer-related molecular mechanisms research
Protein Degradation and Inhibitors
Epigenetics and DNA Methylation
Stephanie D. Byrum
University of Arkansas for Medical Sciences
Cancer-related molecular mechanisms research
Protein Degradation and Inhibitors
Epigenetics and DNA Methylation
Beverly Word
National Center for Toxicological Research
Cancer-related molecular mechanisms research
Epigenetics and DNA Methylation
Gene expression and cancer classification
Ricky D. Edmondson
University of Arkansas for Medical Sciences
Cancer-related molecular mechanisms research
Epigenetics and DNA Methylation
Bone Metabolism and Diseases