Stavros C. Manolagas

Federal Grant PI High Impact

Distinguished Professor

UAMS primary University of Arkansas

Also affiliated: United States Department of Veterans Affairs (1984–1987); University of California, Los Angeles (1983); University of Arkansas Medical Center (1998–2021); Veterans Health Administration (1984–1986); University of Manchester (1979); University of California San Diego (1980–1990); Central Arkansas Veterans Healthcare System (1997–2023); VA San Diego Healthcare System (1987); Richard L. Roudebush VA Medical Center (1989–1994); Salford Royal Hospital (1979); VA Sepulveda Ambulatory Care Center (1983); Scripps Clinic (1989); John L. McClellan Memorial Veterans Hospital (1995–1999); Indiana University Indianapolis (1989–1994); Indiana University School of Medicine (1989–1994); Indiana University – Purdue University Indianapolis (1989–1994); Indiana University (1989–1994)

Internal Med, College of Medicine

85 h-index 182 pubs 29,399 cited

Research Areas

Biomedical Subjects

Links

ORCID Google Scholar Lab Website Research Group UAMS TRI Profile

OverviewAI-generated summary

Stavros C. Manolagas' research focuses on the fundamental regulatory mechanisms governing the birth and death of bone cells, with significant implications for understanding and treating osteoporosis. His work has investigated the role of various factors, including glucocorticoids, estrogen loss, and androgens, in influencing osteoblastogenesis and osteoclast development. He has also explored the impact of matrix-embedded cells on osteoclast formation and the potential of parathyroid hormone to prevent osteoblast apoptosis and increase bone formation.

Manolagas' scholarship includes over 180 publications, with an h-index of 85 and more than 29,000 citations, indicating a substantial body of highly cited work. He has served as PI on federal grants, including funding from the NIH for research on androgens, estrogens, and bone loss in males. His collaborations within the University of Arkansas for Medical Sciences include extensive work with researchers such as Horacio Gómez-Acevedo, Michela Palmieri, Elena Ambrogini, and Teenamol E. Joseph.

Metrics

h-index: 85
Publications: 182
Citations: 29,399

Positions

Distinguished Professor of Medicine and Professor of Orthopedics 2006–present

University of Arkansas for Medical Sciences Internal Medicine and Orthopedics ORCID
Distinguished Professor 1994–present

University of Arkansas for Medical Sciences Internal Med, College of Medicine Institutional directory
Retired 1994–present

VA Medical Center ORCID

Selected Publications

Deletion of the scavenger receptor Scarb1 in osteoblast progenitors and myeloid cells does not affect bone mass (2025)

DOI OpenAlex
Deletion of the scavenger receptor <i>Scarb1</i> in osteoblast progenitors and myeloid cells does not affect bone mass (2025)

DOI OpenAlex
Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humans (2025)

1 citation DOI OpenAlex
OR27-02 The Bone Anabolic Effect Of An Antibody Blocking Oxidized Phospholipids Is Associated With An Increase In Wnt10b In Osteoblasts. (2023)

DOI OpenAlex
RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression (2023)

Molecular Cell 26 citations DOI OpenAlex
Retraction notice to “Deletion of the scavenger receptor Scarb1 in myeloid cells does not affect bone mass” [Bone 170(2023) 116702] (2023)

DOI OpenAlex
RETRACTED: Deletion of the scavenger receptor Scarb1 in myeloid cells does not affect bone mass (2023)

2 citations DOI OpenAlex
Deletion of the Scavenger Receptor Scarb1 in Myeloid Cells Does Not Affect Bone Mass (2022)

DOI OpenAlex
Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency (2022)

Scientific Reports 18 citations DOI OpenAlex
Mmp13 deletion in mesenchymal cells increases bone mass and attenuates the cortical bone loss caused by estrogen deficiency (2022)

DOI OpenAlex
Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass (2022)

2 citations DOI OpenAlex
Neutralization of oxidized phospholipids attenuates age‐associated bone loss in mice (2021)

Aging Cell 32 citations DOI OpenAlex
<i>Mmp-13</i> deletion in cells of the mesenchymal lineage increases bone mass, decreases endocortical osteoclast number, and attenuates the cortical bone loss caused by estrogen deficiency in mice (2021)

DOI OpenAlex
Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency (2021)

JCI Insight 100 citations DOI OpenAlex
Increased marrow adipogenesis does not contribute to age‐dependent appendicular bone loss in female mice (2020)

Aging Cell 36 citations DOI OpenAlex

View all publications on OpenAlex →

Federal Grants 1

VA Contact PI Jan 2012 - Mar 2021

Androgens, estrogens, and bone loss in males

Administered by Central Arkansas Veterans Healthcare System I01

Grants & Funding

As listed on this researcher's institutional profile. Federal awards with verified records are shown above.

Role of FoxOs in Skeletal Homeostasis- Resubmission - Continuation-Continuation - Continuation - Continuation NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases Co-Investigator
ESTROGENS AND OSTEOCLASTOGENESIS NIH Principal Investigator
Center for Musculoskeletal Disease Research (CMDR) NIH/Nat. Inst. of General Medical Sciences Co-Investigator
HORMONAL CONTROL OF CYTOKINES IN BONE AND STROMAL CELLS NIH Principal Investigator
Molecular and Cellular Mechanisms of Osteoporosis NIH Principal Investigator
OSTEOBLAST COMMITMENT AND DIFFERENTIATION BY ANGELS NIH Co-Principal Investigator
1,25 DIHYDROXY VITAMIN D3 AND CELLULAR IMMUNITY NIH Principal Investigator