Stavros C. Manolagas
High Impact
Distinguished Professor
faculty
Internal Med, College of Medicine
85 h-index
184 pubs
29,054 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Stavros C. Manolagas, Distinguished Professor in Internal Medicine at the University of Arkansas for Medical Sciences, investigates mechanisms of bone loss and bone anabolism. His research group studies the role of cellular components and signaling pathways in skeletal health, particularly in the context of aging and hormonal changes.
Recent publications from his laboratory have explored the contribution of mitochondrial Sirt3 to age-associated bone loss and the effects of neutralizing oxidized phospholipids on this process in mice. Other work has examined the function of the RANK ligand in osteoclast gene expression and the impact of deleting specific scavenger receptors in myeloid cells and osteoblast progenitors on bone mass. His group has also investigated the bone anabolic effects of antibodies that block oxidized phospholipids, linking these effects to Wnt10b signaling in osteoblasts.
Manolagas holds an h-index of 85, with 183 publications cited over 28,918 times. He is recognized as a highly cited researcher. Key collaborators at the University of Arkansas for Medical Sciences include Horacio Gómez-Acevedo, Elena Ambrogini, Michela Palmieri, and Teenamol E. Joseph.
Metrics
- h-index: 85
- Publications: 184
- Citations: 29,054
Selected Publications
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Deletion of the scavenger receptor Scarb1 in osteoblast progenitors and myeloid cells does not affect bone mass (2025)
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Deletion of the scavenger receptor <i>Scarb1</i> in osteoblast progenitors and myeloid cells does not affect bone mass (2025)
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Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humans (2025)
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OR27-02 The Bone Anabolic Effect Of An Antibody Blocking Oxidized Phospholipids Is Associated With An Increase In Wnt10b In Osteoblasts. (2023)
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RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression (2023)
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Retraction notice to “Deletion of the scavenger receptor Scarb1 in myeloid cells does not affect bone mass” [Bone 170(2023) 116702] (2023)
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RETRACTED: Deletion of the scavenger receptor Scarb1 in myeloid cells does not affect bone mass (2023)
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Deletion of the Scavenger Receptor Scarb1 in Myeloid Cells Does Not Affect Bone Mass (2022)
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Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency (2022)
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Mmp13 deletion in mesenchymal cells increases bone mass and attenuates the cortical bone loss caused by estrogen deficiency (2022)
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Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass (2022)
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Neutralization of oxidized phospholipids attenuates age‐associated bone loss in mice (2021)
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<i>Mmp-13</i> deletion in cells of the mesenchymal lineage increases bone mass, decreases endocortical osteoclast number, and attenuates the cortical bone loss caused by estrogen deficiency in mice (2021)
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Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency (2021)
Grants & Funding
- Role of FoxOs in Skeletal Homeostasis- Resubmission - Continuation-Continuation - Continuation - Continuation NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases Co-Investigator
- ESTROGENS AND OSTEOCLASTOGENESIS NIH Principal Investigator
- Center for Musculoskeletal Disease Research (CMDR) NIH/Nat. Inst. of General Medical Sciences Co-Investigator
- HORMONAL CONTROL OF CYTOKINES IN BONE AND STROMAL CELLS NIH Principal Investigator
- Molecular and Cellular Mechanisms of Osteoporosis NIH Principal Investigator
- Androgens, estrogens, and bone loss in males NIH Principal Investigator
- OSTEOBLAST COMMITMENT AND DIFFERENTIATION BY ANGELS NIH Co-Principal Investigator
- 1,25 DIHYDROXY VITAMIN D3 AND CELLULAR IMMUNITY NIH Principal Investigator
Collaboration Network
Top Collaborators
Horacio Gómez-Acevedo
University of Arkansas for Medical Sciences
11 shared publications
In database
- Neutralization of oxidized phospholipids attenuates age‐associated bone loss in mice
- Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency
- Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass
- RETRACTED: Deletion of the scavenger receptor Scarb1 in myeloid cells does not affect bone mass
- Retraction: Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass
Showing 5 of 11 shared publications
Michela Palmieri
University of Arkansas for Medical Sciences
9 shared publications
In database
- Neutralization of oxidized phospholipids attenuates age‐associated bone loss in mice
- Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass
- RETRACTED: Deletion of the scavenger receptor Scarb1 in myeloid cells does not affect bone mass
- Retraction: Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass
- Blocking Oxidized Phospholipids Attenuates the Age-Associated, but Not the Ovariectomy- or Unloading- Induced, Bone Loss in Mice
Showing 5 of 9 shared publications
Elena Ambrogini
University of Arkansas for Medical Sciences
9 shared publications
In database
- Neutralization of oxidized phospholipids attenuates age‐associated bone loss in mice
- Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass
- RETRACTED: Deletion of the scavenger receptor Scarb1 in myeloid cells does not affect bone mass
- Retraction: Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass
- Blocking Oxidized Phospholipids Attenuates the Age-Associated, but Not the Ovariectomy- or Unloading- Induced, Bone Loss in Mice
Showing 5 of 9 shared publications
Ha‐Neui Kim
University of Arkansas for Medical Sciences
8 shared publications
In database
- Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
- Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency
- RETRACTED: Deletion of the scavenger receptor Scarb1 in myeloid cells does not affect bone mass
- <i>Mmp-13</i> deletion in cells of the mesenchymal lineage increases bone mass, decreases endocortical osteoclast number, and attenuates the cortical bone loss caused by estrogen deficiency in mice
- Mmp13 deletion in mesenchymal cells increases bone mass and attenuates the cortical bone loss caused by estrogen deficiency
Showing 5 of 8 shared publications
Teenamol E. Joseph
Central Arkansas Veterans Healthcare System
8 shared publications
In database
- Neutralization of oxidized phospholipids attenuates age‐associated bone loss in mice
- Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass
- RETRACTED: Deletion of the scavenger receptor Scarb1 in myeloid cells does not affect bone mass
- Retraction: Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass
- Blocking Oxidized Phospholipids Attenuates the Age-Associated, but Not the Ovariectomy- or Unloading- Induced, Bone Loss in Mice
Showing 5 of 8 shared publications
Maria Almeida
Central Arkansas Veterans Healthcare System
6 shared publications
In database
- Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
- Neutralization of oxidized phospholipids attenuates age‐associated bone loss in mice
- RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression
- Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency
- <i>Mmp-13</i> deletion in cells of the mesenchymal lineage increases bone mass, decreases endocortical osteoclast number, and attenuates the cortical bone loss caused by estrogen deficiency in mice
Showing 5 of 6 shared publications
Charles A. O’Brien
Central Arkansas Veterans Healthcare System
6 shared publications
In database
- Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass
- RETRACTED: Deletion of the scavenger receptor Scarb1 in myeloid cells does not affect bone mass
- Retraction: Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass
- Deletion of the Scavenger Receptor Scarb1 in Myeloid Cells Does Not Affect Bone Mass
- Retraction notice to “Deletion of the scavenger receptor Scarb1 in myeloid cells does not affect bone mass” [Bone 170(2023) 116702]
Showing 5 of 6 shared publications
Aaron Warren
University of Arkansas for Medical Sciences
5 shared publications
In database
- Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
- Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency
- Blocking Oxidized Phospholipids Attenuates the Age-Associated, but Not the Ovariectomy- or Unloading- Induced, Bone Loss in Mice
- <i>Mmp-13</i> deletion in cells of the mesenchymal lineage increases bone mass, decreases endocortical osteoclast number, and attenuates the cortical bone loss caused by estrogen deficiency in mice
- Mmp13 deletion in mesenchymal cells increases bone mass and attenuates the cortical bone loss caused by estrogen deficiency
Filipa Ponte
University of Arkansas for Medical Sciences
5 shared publications
In database
- Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
- RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression
- Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency
- <i>Mmp-13</i> deletion in cells of the mesenchymal lineage increases bone mass, decreases endocortical osteoclast number, and attenuates the cortical bone loss caused by estrogen deficiency in mice
- Mmp13 deletion in mesenchymal cells increases bone mass and attenuates the cortical bone loss caused by estrogen deficiency
Intawat Nookaew
University of Arkansas for Medical Sciences
5 shared publications
In database
- Neutralization of oxidized phospholipids attenuates age‐associated bone loss in mice
- Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency
- <i>Mmp-13</i> deletion in cells of the mesenchymal lineage increases bone mass, decreases endocortical osteoclast number, and attenuates the cortical bone loss caused by estrogen deficiency in mice
- Mmp13 deletion in mesenchymal cells increases bone mass and attenuates the cortical bone loss caused by estrogen deficiency
- OR27-02 The Bone Anabolic Effect Of An Antibody Blocking Oxidized Phospholipids Is Associated With An Increase In Wnt10b In Osteoblasts.
Srividhya Iyer
University of Arkansas for Medical Sciences (US)
3 shared publications
- Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency
- <i>Mmp-13</i> deletion in cells of the mesenchymal lineage increases bone mass, decreases endocortical osteoclast number, and attenuates the cortical bone loss caused by estrogen deficiency in mice
- Mmp13 deletion in mesenchymal cells increases bone mass and attenuates the cortical bone loss caused by estrogen deficiency
Erin M. Mannen
University of Arkansas for Medical Sciences (US)
3 shared publications
- Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency
- <i>Mmp-13</i> deletion in cells of the mesenchymal lineage increases bone mass, decreases endocortical osteoclast number, and attenuates the cortical bone loss caused by estrogen deficiency in mice
- Mmp13 deletion in mesenchymal cells increases bone mass and attenuates the cortical bone loss caused by estrogen deficiency
Joseph L. Witztum
University of California, San Diego (US)
2 shared publications
- Neutralization of oxidized phospholipids attenuates age‐associated bone loss in mice
- Blocking Oxidized Phospholipids Attenuates the Age-Associated, but Not the Ovariectomy- or Unloading- Induced, Bone Loss in Mice
Wen Ling
1 shared publication
In database
- Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
Kimberly J. Krager
University of Arkansas for Medical Sciences
1 shared publication
In database
- Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
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