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Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-15
I
Igor Koturbash
High Impact
Professor
Also affiliated: University of Lethbridge (2005–2016); United States Food and Drug Administration (2010–2012); University of Occupational and Environmental Health Japan (2015); Center for Environmental Health (2015); Office of Dietary Supplements (2024); Arkansas Department of Health (2014–2019)
Faculty Researcher
Environmental Health Sciences, College of Public Health
45 h-index
155 pubs
6,250 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Igor Koturbash's research focuses on the cytogenetic and epigenetic effects of environmental exposures, particularly concerning DNA damage and its implications for health. His work investigates mechanisms of toxicity, including hepatotoxicity from herbal supplements and the impact of dietary deficiencies. He has published on the effects of ionizing radiation, environmental factors like particulate matter, and the analysis of supplement usage in the context of public health challenges such as the COVID-19 pandemic.
His research utilizes animal models, specifically mice, as well as human peripheral lymphocytes to study genetic instability and epigenetic aberrations. Koturbash has received funding for and published on studies related to radiation therapy and dietary interventions, as well as the regulation of dietary supplements. He maintains an active research group and collaborates with colleagues at the University of Arkansas for Medical Sciences, with multiple shared publications with Marjan Boerma, Laura Ewing, Charles M. Skinner, and Rupak Pathak.
With a significant publication record (155 publications, 6,190 citations, h-index of 44), Koturbash is recognized as a highly cited researcher. His scholarship extends to public health issues, including the health impacts of climate change on rural communities and the potential drug interactions of botanicals.
Metrics
- h-index: 45
- Publications: 155
- Citations: 6,250
Selected Publications
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(6S)-5-Methyltetrahydrofolate Dicholine Salt Modulates Methyl-Donor Metabolites and Repetitive-Element DNA Methylation in HepaRG Cells (2026)
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Co-occurring substance use disorders and the compounding effect of kratom on serious mental illness, US, 2021–2023 (2026)
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From kratom to 7-hydroxymitragynine: evolution of a natural remedy into a public-health threat (2025)
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Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice (2025)
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A Systematic and Ethnobotanical Review of Ashwagandha's ( <scp> <i>Withania Somnifera</i> </scp> ) Teratogenic and Abortifacient Potentials (2025)
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Sex-specific immune alterations in mice following long-term simulated microgravity and chronic irradiation (2025)
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Long-term effects of combined exposures to simulated microgravity and galactic cosmic radiation on the mouse lung: sex-specific epigenetic reprogramming (2025)
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A Combined Approach for Rapid Dereplication of Herb–Drug Interaction Causative Agents in Botanical Extracts─A Molecular Networking Strategy To Identify Potential Pregnane X Receptor (PXR) Modulators in Yohimbe (2024)
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Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading (2024)
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First-year evaluation of a campus-wide, cross-disciplinary scholarly writing development program supported by a center for biomedical research excellence (COBRE) (2024)
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DSHEA 1994 – Celebrating 30 Years of Dietary Supplement Regulation in the United States (2024)
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Developing a Screening Strategy to Identify Hepatotoxicity and Drug Interaction Potential of Botanicals (2024)
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Botanical-induced toxicity: Liver injury and botanical-drug interactions. A report on a society of Toxicology Annual Meeting symposium (2024)
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Phenibut: A drug with one too many “buts” (2024)
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Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract (2024)
Grants & Funding
As listed on this researcher's institutional profile.
- Analysis of hepatotoxicity of the OxyELITE Pro dietary supplement in a mouse model US Department of Justice Principal Investigator
- The Diversity Outbred: A Tool to Improve Preclinical Safety Testing and Pharmacog U.S. Food and Drug Administration Principal Investigator
- Integration of in-silico and in-vivo Models for Determining Preclinical Indicators and/or Integrated Biomarkers of Radiation-Induced Vascular Dysfunction National Aeronautics & Space Administration via Louisiana State University Principal Investigator
- Team Leader for the Radiation Effects Team National Space Biomedical Research Institute via Baylor College of Medicine Co-Investigator
- Center for Studies of Host Response to Cancer Therapy NIH Co-Investigator
- Arkansas Center for Health Disparities (ARCHD): An NIMHD COE NIH Co-Investigator
- Effects of wood burning-associated smoke on satellite DNA NIH/Nat. Inst. for Occupational Safety & Health via University of Alabama at Birmingham Principal Investigator
- In vitro screening of a unique botanical extract collection for herb-drug interaction (HDI) potential NIH/National Center for Complementary and Integrative Health via University of Mississippi Principal Investigator
Collaboration Network
Top Collaborators
Marjan Boerma
University of Arkansas for Medical Sciences
8 shared publications
In database
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model
- Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading
- A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment
Showing 5 of 8 shared publications
Bill J. Gurley
University of Mississippi
6 shared publications
In database
- Hepatotoxicity due to herbal dietary supplements: Past, present and the future
- Developing a Screening Strategy to Identify Hepatotoxicity and Drug Interaction Potential of Botanicals
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
- Phenibut: A drug with one too many “buts”
- A Combined Approach for Rapid Dereplication of Herb–Drug Interaction Causative Agents in Botanical Extracts─A Molecular Networking Strategy To Identify Potential Pregnane X Receptor (PXR) Modulators in Yohimbe
Showing 5 of 6 shared publications
Isabelle R. Miousse
University of Arkansas for Medical Sciences
5 shared publications
In database
- Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells
- Climate Change and New Challenges for Rural Communities: Particulate Matter Matters
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model
- Methylsulfonylmethane Serves as a Donor of Methyl Groups for Methylation of DNA in Human Liver HepaRG Cells
- Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice
Rupak Pathak
University of Arkansas for Medical Sciences
5 shared publications
In database
- Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- Methods for induction and assessment of intestinal permeability in rodent models of radiation injury
- Sex-specific immune alterations in mice following long-term simulated microgravity and chronic irradiation
- Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice
Laura Ewing
University of Arkansas for Medical Sciences
5 shared publications
In database
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model
- Methods for induction and assessment of intestinal permeability in rodent models of radiation injury
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
- Inter-strain variability in responses to a single administration of the cannabidiol-rich cannabis extract in mice
Charles M. Skinner
University of Arkansas for Medical Sciences
5 shared publications
In database
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
- Inter-strain variability in responses to a single administration of the cannabidiol-rich cannabis extract in mice
- Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice
Mitchell R. McGill
University of Arkansas for Medical Sciences
5 shared publications
In database
- Hepatotoxicity due to herbal dietary supplements: Past, present and the future
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
- Natural Products That Protect Against Acetaminophen Hepatotoxicity: A Call for Increased Rigor in Preclinical Studies of Dietary Supplements
- Methylsulfonylmethane Serves as a Donor of Methyl Groups for Methylation of DNA in Human Liver HepaRG Cells
- (6S)-5-Methyltetrahydrofolate Dicholine Salt Modulates Methyl-Donor Metabolites and Repetitive-Element DNA Methylation in HepaRG Cells
Martin Hauer‐Jensen
University of Arkansas for Medical Sciences
4 shared publications
In database
- Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- Methods for induction and assessment of intestinal permeability in rodent models of radiation injury
- Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice
Kirsten Clement
University of Arkansas for Medical Sciences
4 shared publications
In database
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
- Inter-strain variability in responses to a single administration of the cannabidiol-rich cannabis extract in mice
- Methylsulfonylmethane Serves as a Donor of Methyl Groups for Methylation of DNA in Human Liver HepaRG Cells
- (6S)-5-Methyltetrahydrofolate Dicholine Salt Modulates Methyl-Donor Metabolites and Repetitive-Element DNA Methylation in HepaRG Cells
Jeffrey S. Willey
Wake Forest University (US)
4 shared publications
- A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment
- Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading
- A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment
- Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice
Stepan Melnyk
University of Arkansas for Medical Sciences
3 shared publications
In database
- Methods for induction and assessment of intestinal permeability in rodent models of radiation injury
- Methylsulfonylmethane Serves as a Donor of Methyl Groups for Methylation of DNA in Human Liver HepaRG Cells
- Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice
Reid D. Landes
University of Arkansas for Medical Sciences
3 shared publications
In database
- Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model
- First-year evaluation of a campus-wide, cross-disciplinary scholarly writing development program supported by a center for biomedical research excellence (COBRE)
Vijayalakshmi Sridharan
University of Arkansas for Medical Sciences
3 shared publications
In database
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model
- Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading
- Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice
Malcolm D. Mattes
Rutgers Cancer Institute of New Jersey
3 shared publications
- A Phase I Trial of a Methionine Restricted Diet with Concurrent Radiation Therapy
- Safety and Feasibility of the Addition of a Radiosensitizing Methionine-Restricted Diet to Radiation Therapy
- Safety and feasibility of the addition of a radiosensitizing methionine-restricted diet to radiation therapy.
Calvin N. Leung
Rutgers, The State University of New Jersey (US)
3 shared publications
- A Phase I Trial of a Methionine Restricted Diet with Concurrent Radiation Therapy
- Safety and Feasibility of the Addition of a Radiosensitizing Methionine-Restricted Diet to Radiation Therapy
- Safety and feasibility of the addition of a radiosensitizing methionine-restricted diet to radiation therapy.
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