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Confirmed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
N
Nan Mei
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Research Scientist
Also affiliated: United States Food and Drug Administration (2004–2026); Institute of Cancer Research (2011); Iowa State University (2021); University of Occupational and Environmental Health Japan (1996–2007); Tianjin Medical University General Hospital (2015); Cross Cancer Institute (2003); Tianjin Medical University (2015)
42 h-index
148 pubs
9,201 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Nan Mei's research focuses on the assessment of toxicological potential and the development of reliable methods for gene expression analysis. Her work has contributed to understanding the genotoxicity of various substances, including pyrrolizidine alkaloids and graphene family nanomaterials. Mei has participated in significant consortia such as the MicroArray Quality Control (MAQC) project and the Sequencing Quality Control Consortium, which have evaluated the reproducibility and accuracy of gene expression measurement platforms like microarrays and RNA-sequencing across different laboratories and technologies.
Her publications include studies on the toxic potential of nanomaterials, the genotoxicity of specific chemical compounds, and comprehensive assessments of RNA-seq and microarray technologies. Mei has also been involved in creating transcriptomic atlases, such as a rat RNA-Seq transcriptomic BodyMap. Her research interests encompass both the evaluation of chemical safety and the refinement of molecular biology techniques used in toxicological research, investigating gene expression changes in response to various exposures and conditions.
Mei's scholarly contributions are reflected in her h-index of 42 and over 9,000 citations across nearly 200 publications. She has a strong network of collaborators at the National Center for Toxicological Research, including Xilin Li, Xiaoqing Guo, Robert H. Heflich, and Ji‐Eun Seo, with whom she has co-authored numerous publications. Mei is identified as a highly cited researcher, indicating a significant impact within her field.
Metrics
- h-index: 42
- Publications: 148
- Citations: 9,201
Positions
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Research Scientist 2002–presentNational Center for Toxicological Research Division of Genetic and Molecular Toxicology ORCID
Selected Publications
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OS03-08 Integrated genotoxicity testing of multiple endpoints in human TK6 cells (2026)
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Adjusting the Preincubation Conditions to Enhance the Ames Test for Detecting the Mutagenicity of N ‐Nitrosamines (2026)
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Mutagenicity of EAT-positive NDSRIs in HepaRG spheroids (2026)
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S03-04 Induction of genomic damage by natural plant constituents: development of genotoxicity testing strategies (2025)
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Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models (2025)
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Potential anticancer effects and toxicity of flavones luteolin and apigenin in vivo (2025)
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Review of black cohosh-induced toxicity and adverse clinical effects (2025)
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Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing (2025)
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A proposed screening strategy for evaluating the genotoxicity potential of botanicals and botanical extracts (2025)
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Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells (2024)
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Optimizing the detection of N-nitrosamine mutagenicity in the Ames test (2024)
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Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations (2024)
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Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing (2024)
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Use of Lentivirus‐Based Method for Establishing TK6 Human Cell Lines Expressing Cytochrome P450 and its Applications in Genotoxicity Testing (2024)
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Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells (2024)
Collaboration Network
Top Collaborators
Lei Guo
National Center for Toxicological Research
41 shared publications
In database
- A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium
- A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
- Rat toxicogenomic study reveals analytical consistency across microarray platforms
- The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies
- Review of Ginkgo biloba -induced toxicity, from experimental studies to human case reports
Showing 5 of 41 shared publications
Xiaoqing Guo
National Center for Toxicological Research
41 shared publications
In database
- Assessment of the toxic potential of graphene family nanomaterials
- Aloe vera: A review of toxicity and adverse clinical effects
- Review of Ginkgo biloba -induced toxicity, from experimental studies to human case reports
- Silver nanoparticle‐induced mutations and oxidative stress in mouse lymphoma cells
- The Genotoxicity of Acrylamide and Glycidamide in Big Blue Rats
Showing 5 of 41 shared publications
Robert H. Heflich
National Center for Toxicological Research
23 shared publications
In database
- DNA adduct formation and mutation induction by aristolochic acid in rat kidney and liver
- Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice
- The Genotoxicity of Acrylamide and Glycidamide in Big Blue Rats
- Mutagenicity of comfrey (Symphytum Officinale) in rat liver
- Nitroxide TEMPO: A genotoxic and oxidative stress inducer in cultured cells
Showing 5 of 23 shared publications
Mugimane G. Manjanatha
National Center for Toxicological Research
17 shared publications
In database
- In vivo genotoxicity testing strategies: Report from the 7th International workshop on genotoxicity testing (IWGT)
- Mutagenicity of Acrylamide and Glycidamide in the Testes of Big Blue Mice
- Mechanistic Evaluation of Ginkgo biloba Leaf Extract-Induced Genotoxicity in L5178Y Cells
- Gene expression changes associated with xenobiotic metabolism pathways in mice exposed to acrylamide
- Performance of high-throughput CometChip assay using primary human hepatocytes: a comparison of DNA damage responses with in vitro human hepatoma cell lines
Showing 5 of 17 shared publications
Martha M. Moore
17 shared publications
- Silver nanoparticle‐induced mutations and oxidative stress in mouse lymphoma cells
- Genotoxic effects of acrylamide and glycidamide in mouse lymphoma cells
- The Mouse Lymphoma Assay Detects Recombination, Deletion, and Aneuploidy
- Mechanistic Evaluation of Ginkgo biloba Leaf Extract-Induced Genotoxicity in L5178Y Cells
- Nitroxide TEMPO: A genotoxic and oxidative stress inducer in cultured cells
Showing 5 of 17 shared publications
Si Chen
National Center for Toxicological Research
15 shared publications
In database
- Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells
- Sertraline, an Antidepressant, Induces Apoptosis in Hepatic Cells Through the Mitogen-Activated Protein Kinase Pathway
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- Mechanism study of goldenseal-associated DNA damage
- The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p
Showing 5 of 15 shared publications
James C. Fuscoe
National Center for Toxicological Research
13 shared publications
In database
- A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium
- A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
- The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies
- Metabolism, Genotoxicity, annd Carcinogenicity of Comfrey
- Gene Expression Profiles Distinguish the Carcinogenic Effects of Aristolochic Acid in Target (Kidney) and Non-target (Liver) Tissues in Rats
Showing 5 of 13 shared publications
Peter P. Fu
13 shared publications
- Genotoxicity of pyrrolizidine alkaloids
- Metabolism, Genotoxicity, annd Carcinogenicity of Comfrey
- Photodecomposition of Vitamin A and Photobiological Implications for the Skin†
- Mutagenicity of comfrey (Symphytum Officinale) in rat liver
- Ginkgo Biloba Extract Induces Gene Expression Changes in Xenobiotics Metabolism and the Myc-Centered Network
Showing 5 of 13 shared publications
Ji‐Eun Seo
National Center for Toxicological Research
13 shared publications
In database
- Genetic toxicity assessment using liver cell models: past, present, and future
- Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Performance of HepaRG and HepG2 cells in the high-throughput micronucleus assay for in vitro genotoxicity assessment
- Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells
Showing 5 of 13 shared publications
Xilin Li
National Center for Toxicological Research
13 shared publications
In database
- Genetic toxicity assessment using liver cell models: past, present, and future
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- The role of hepatic cytochrome P450s in the cytotoxicity of sertraline
- Optimizing the detection of N-nitrosamine mutagenicity in the Ames test
Showing 5 of 13 shared publications
Tao Chen
National Center for Toxicological Research (US)
10 shared publications
- Metabolism, Genotoxicity, annd Carcinogenicity of Comfrey
- Genotoxic effects of acrylamide and glycidamide in mouse lymphoma cells
- The Mouse Lymphoma Assay Detects Recombination, Deletion, and Aneuploidy
- Photomutagenicity of Retinyl Palmitate by Ultraviolet A Irradiation in Mouse Lymphoma Cells
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
Showing 5 of 10 shared publications
Stacey L. Dial
National Center for Toxicological Research (US)
10 shared publications
- Mechanistic Evaluation of Ginkgo biloba Leaf Extract-Induced Genotoxicity in L5178Y Cells
- Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale)
- Gene expression changes associated with xenobiotic metabolism pathways in mice exposed to acrylamide
- Quantitative analysis of the relative mutagenicity of five chemical constituents of tobacco smoke in the mouse lymphoma assay
- Gene expression profiling in male B6C3F1 mouse livers exposed to kava identifies – Changes in drug metabolizing genes and potential mechanisms linked to kava toxicity
Showing 5 of 10 shared publications
Yuan Le
National Center for Toxicological Research
10 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
Showing 5 of 10 shared publications
Baitang Ning
National Center for Toxicological Research
9 shared publications
In database
- A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium
- A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
- MicroRNA hsa-miR-29a-3p modulates CYP2C19 in human liver cells
- The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p
- Activation of the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells
Showing 5 of 9 shared publications
Leming Shi
Fudan University (CN)
8 shared publications
- The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements
- The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements
- The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- Gene Expression Profiles Distinguish the Carcinogenic Effects of Aristolochic Acid in Target (Kidney) and Non-target (Liver) Tissues in Rats
Showing 5 of 8 shared publications
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