Nan Mei Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Research Scientist

National Center for Toxicological Research

staff

42 h-index 188 pubs 9,246 cited

Research Areas

Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Soil and Water Nutrient Dynamics Geological and Geochemical Analysis Analytical Chemistry and Chromatography Receptor Mechanisms and Signaling

Links

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OverviewAI-generated summary

Nan Mei's research focuses on evaluating the genotoxicity and mutagenicity of various chemical compounds, particularly in relation to human health and toxicological assessment. Her work involves in vitro assays using human cell lines, such as TK6 cells, to investigate the potential for DNA damage and mutations. She has studied the influence of specific enzymes, like cytochrome P450s (CYPs), on the genotoxic potential of compounds, including luteolin and nitrosamine impurities. This involves characterizing CYP-overexpressing cell lines to better predict drug and chemical-induced toxicity, especially liver toxicity.

Her recent publications also address environmental toxicology, specifically the assessment of heavy metal pollution in agricultural soils. Mei investigates the sources and contamination levels of heavy metals originating from industrial activities and coal gangue stacking areas. She employs methods such as isotope fingerprints and receptor models to trace and quantify these pollutants. Her research also touches upon the long-term effects of different fertilization practices on soil bacterial communities in agroecosystems.

Mei has a significant publication record with 188 total publications and a citation count of 9,246, achieving an h-index of 42. She is recognized as a highly cited researcher. Key collaborators include Robert H. Heflich, Yuan Le, Ji-Eun Seo, and Xilin Li, all affiliated with the National Center for Toxicological Research, with whom she has co-authored multiple publications.

Metrics

  • h-index: 42
  • Publications: 188
  • Citations: 9,246

Selected Publications

  • Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models (2025) DOI
  • Potential anticancer effects and toxicity of flavones luteolin and apigenin <i>in vivo</i> (2025) DOI
  • Review of black cohosh-induced toxicity and adverse clinical effects (2025) DOI
  • A proposed screening strategy for evaluating the genotoxicity potential of botanicals and botanical extracts (2025) DOI
  • Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells (2024) DOI
  • Optimizing the detection of N-nitrosamine mutagenicity in the Ames test (2024) DOI
  • Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations (2024) DOI
  • Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing (2024) DOI
  • Use of Lentivirus‐Based Method for Establishing TK6 Human Cell Lines Expressing Cytochrome P450 and its Applications in Genotoxicity Testing (2024) DOI
  • Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells (2024) DOI
  • The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib (2023) DOI
  • Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models (2023) DOI
  • Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays (2023) DOI
  • High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing (2023) DOI
  • Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s (2022) DOI

Collaborators

Researchers in the database who share publications

Robert H. Heflich National Center for Toxicological Research 10 shared publications Yuan Le National Center for Toxicological Research 10 shared publications Ji‐Eun Seo National Center for Toxicological Research 8 shared publications Xilin Li National Center for Toxicological Research 7 shared publications Xiaobo He National Center for Toxicological Research 6 shared publications Mugimane G. Manjanatha National Center for Toxicological Research 5 shared publications Matthew Bryant National Center for Toxicological Research 5 shared publications Roberta A. Mittelstaedt National Center for Toxicological Research 4 shared publications

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