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Current · Arkansas
Last published
2025
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OpenAlex · ORCID
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2026-10-06
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Xiaobo He
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Also affiliated: Ningbo University (2025); United States Food and Drug Administration (2015–2025); University of North Carolina at Greensboro (2018–2020); Beijing Normal University (2025); China Academy of Engineering Physics (2010–2011); Tianjin Medical University (2014–2015)
16 h-index
45 pubs
564 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Xiaobo He's research focuses on the toxicological evaluation of pyrrolizidine alkaloids and other chemical compounds. He investigates the mechanisms by which these substances can cause DNA damage and contribute to carcinogenesis. His work includes the identification of reactive metabolites, such as 7-glutathione pyrrole adduct and 7-cysteine-pyrrole conjugate, formed from pyrrolizidine alkaloids, and examines their role in potential liver tumor initiation. He also studies the genotoxicity of other compounds, including luteolin and nitrosamine impurities, often utilizing human cell lines engineered to express specific cytochrome P450 enzymes. His research has extended to evaluating DNA damage and repair pathway dysregulation in populations exposed to environmental contaminants like persistent organic pollutants in electronic waste. He has also investigated gene expression changes associated with occupational exposures, such as benzene in workers. He has published 49 papers, with an h-index of 16 and 593 citations, and collaborates with researchers at the National Center for Toxicological Research.
Metrics
- h-index: 16
- Publications: 45
- Citations: 564
Selected Publications
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Mechanistic study of pexidartinib-induced toxicity in human hepatic cells (2025)
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Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing (2025)
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Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes (2025)
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An efficient enzymatic system for studying structure-carcinogenicity relationships: metabolism of pyrrolizidine alkaloids by human liver microsomes in the presence of calf thymus DNA, resulting in the formation of DNA adducts (2024)
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Pharmacokinetic analysis of nicotine and its metabolites (cotinine and trans-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine (2024)
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Use of Lentivirus‐Based Method for Establishing TK6 Human Cell Lines Expressing Cytochrome P450 and its Applications in Genotoxicity Testing (2024)
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Evaluation of a microphysiological human placental barrier model for studying placental drug transfer (2023)
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The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib (2023)
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Formation of DHP-DNA Adducts from Rat Liver Microsomal Metabolism of 1,2-Unsaturated Pyrrolizidine Alkaloid-Containing Plant Extracts and Dietary Supplements (2023)
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Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s (2022)
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Metabolism of carcinogenic pyrrolizidine alkaloids and pyrrolizidine alkaloidN-oxides by rat primary hepatocytes generate the same characteristic DHP-DNA adducts (2021)
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Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta) (2021)
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The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells (2021)
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A UPLC-MRM-MS method for comprehensive profiling of Amadori compound-modified phosphatidylethanolamines in human plasma (2020)
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Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines (2020)
Collaboration Network
Top Collaborators
Qingsu Xia
National Center for Toxicological Research
16 shared publications
In database
- 7-Glutathione Pyrrole Adduct: A Potential DNA Reactive Metabolite of Pyrrolizidine Alkaloids
- Detection of Pyrrolizidine Alkaloid DNA Adducts in Livers of Cattle Poisoned withHeliotropium europaeum
- 7-cysteine-pyrrole conjugate: A new potential DNA reactive metabolite of pyrrolizidine alkaloids
- Pyrrolizidine alkaloid-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N -oxides
- Pyrrolizidine Alkaloid Secondary Pyrrolic Metabolites Construct Multiple Activation Pathways Leading to DNA Adduct Formation and Potential Liver Tumor Initiation
Showing 5 of 16 shared publications
Peter P. Fu
National Center for Toxicological Research (US)
16 shared publications
- 7-Glutathione Pyrrole Adduct: A Potential DNA Reactive Metabolite of Pyrrolizidine Alkaloids
- Detection of Pyrrolizidine Alkaloid DNA Adducts in Livers of Cattle Poisoned withHeliotropium europaeum
- 7-cysteine-pyrrole conjugate: A new potential DNA reactive metabolite of pyrrolizidine alkaloids
- Pyrrolizidine alkaloid-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N -oxides
- Pyrrolizidine Alkaloid Secondary Pyrrolic Metabolites Construct Multiple Activation Pathways Leading to DNA Adduct Formation and Potential Liver Tumor Initiation
Showing 5 of 16 shared publications
Matthew Bryant
National Center for Toxicological Research
11 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Pharmacokinetic analysis of nicotine and its metabolites (cotinine and trans-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine
Showing 5 of 11 shared publications
Nan Mei
Genetic Analysis (Norway)
8 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta)
Showing 5 of 8 shared publications
Ge Lin
Chinese University of Hong Kong (HK)
6 shared publications
- Pyrrolizidine alkaloid-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N -oxides
- Quantitation of DNA reactive pyrrolic metabolites of senecionine – A carcinogenic pyrrolizidine alkaloid by LC/MS/MS analysis
- Primary and secondary pyrrolic metabolites of pyrrolizidine alkaloids form DNA adducts in human A549 cells
- 1-Formyl-7-hydroxy-6,7-dihydro-5H-pyrrolizine (1-CHO-DHP): A Potential Proximate Carcinogenic Metabolite of Pyrrolizidine Alkaloids
- Formation of DHP-DNA Adducts from Rat Liver Microsomal Metabolism of 1,2-Unsaturated Pyrrolizidine Alkaloid-Containing Plant Extracts and Dietary Supplements
Showing 5 of 6 shared publications
Xiaoqing Guo
National Center for Toxicological Research
6 shared publications
In database
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta)
- Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes
Showing 5 of 6 shared publications
Si Chen
Biochemical Society
5 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Mechanistic study of pexidartinib-induced toxicity in human hepatic cells
- Use of Lentivirus‐Based Method for Establishing TK6 Human Cell Lines Expressing Cytochrome P450 and its Applications in Genotoxicity Testing
Lei Guo
Biochemical Society
5 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Mechanistic study of pexidartinib-induced toxicity in human hepatic cells
- Use of Lentivirus‐Based Method for Establishing TK6 Human Cell Lines Expressing Cytochrome P450 and its Applications in Genotoxicity Testing
Liang Ma
National Center for Toxicological Research (US)
4 shared publications
- 7-Glutathione Pyrrole Adduct: A Potential DNA Reactive Metabolite of Pyrrolizidine Alkaloids
- 7-cysteine-pyrrole conjugate: A new potential DNA reactive metabolite of pyrrolizidine alkaloids
- Pyrrolizidine Alkaloid Secondary Pyrrolic Metabolites Construct Multiple Activation Pathways Leading to DNA Adduct Formation and Potential Liver Tumor Initiation
- 7- N -Acetylcysteine-pyrrole conjugate—A potent DNA reactive metabolite of pyrrolizidine alkaloids
Qiangen Wu
National Center for Toxicological Research
3 shared publications
In database
- Primary and secondary pyrrolic metabolites of pyrrolizidine alkaloids form DNA adducts in human A549 cells
- Pharmacokinetic analysis of nicotine and its metabolites (cotinine and trans-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine
- Use of Lentivirus‐Based Method for Establishing TK6 Human Cell Lines Expressing Cytochrome P450 and its Applications in Genotoxicity Testing
Qiang Shi
National Center for Toxicological Research
3 shared publications
In database
- Quantitation of DNA reactive pyrrolic metabolites of senecionine – A carcinogenic pyrrolizidine alkaloid by LC/MS/MS analysis
- Effects of glutathione and cysteine on pyrrolizidine alkaloid-induced hepatotoxicity and DNA adduct formation in rat primary hepatocytes
- Metabolism of carcinogenic pyrrolizidine alkaloids and pyrrolizidine alkaloidN-oxides by rat primary hepatocytes generate the same characteristic DHP-DNA adducts
Xilin Li
Genetic Analysis (Norway)
3 shared publications
In database
- Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Mechanistic study of pexidartinib-induced toxicity in human hepatic cells
Ji‐Eun Seo
National Center for Toxicological Research
3 shared publications
In database
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta)
- Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes
Xilin Li
National Center for Toxicological Research
3 shared publications
In database
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Use of Lentivirus‐Based Method for Establishing TK6 Human Cell Lines Expressing Cytochrome P450 and its Applications in Genotoxicity Testing
- Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing
Mugimane G. Manjanatha
National Center for Toxicological Research
2 shared publications
In database
- Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines
- Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing
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