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Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-20
Melanie C MacNicol
High Impact
Associate Professor
Also affiliated: Arkansas Children's Hospital (2002–2025); University of Chicago (1995–2000); Center for Neurosciences (2019); Winthrop Rockefeller Foundation (2008); Center for Translational Molecular Medicine (2019); Arkansas Department of Agriculture (2002–2011); Health and Human Development (2HD) Research Network (2019); Daiichi Sankyo (United States) (1995); Stanford University (1990–1992)
Faculty Researcher
Neurobiology & Developmental Science, College of Medicine
24 h-index
79 pubs
1,656 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Melanie C MacNicol's research focuses on the post-transcriptional regulation of gene expression, particularly within the pituitary gland and its role in reproductive and metabolic processes. Her work investigates how RNA-binding proteins, such as Musashi, control the translation of specific messenger RNAs, influencing cell function and plasticity. This research is supported by multiple NIH grants totaling over $1.7 million, including funding to study the molecular mechanisms of pituitary plasticity and the impact of obesity on somatotrope function.
Her recent publications explore these themes through various biological models, including breast cancer cell lines and mouse models. Specific studies examine the role of Musashi proteins in regulating gonadotrope target mRNAs during the estrous cycle, the impact of oxidative stress on anterior pituitary transcriptomics following a high-fat diet, and how maternal undernutrition affects offspring gene expression. MacNicol also investigates mechanisms of pituitary cell plasticity through regulated mRNA translation, with recent work exploring the association of Musashi with LSM14B. Her scholarship metrics include an h-index of 23 and over 1,600 citations, with 78 total publications. She actively collaborates with researchers at the University of Arkansas for Medical Sciences.
Metrics
- h-index: 24
- Publications: 79
- Citations: 1,656
Selected Publications
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ELAVL1 and ELAVL4 Are Required for Musashi-Dependent Translational Activation (2026)
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ELAVL1 and ELAVL4 are required for Musashi-dependent translational activation (2026)
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Gonadotrope remodeling in sustained low estrogen states: single-cell transcriptomic analysis reveals gonadotrope subtypes and activation of stem cell populations (2026)
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Secretogranin II–derived peptide secretoneurin differentially stimulates luteinizing hormone secretion by age and sex in ex vivo murine pituitaries (2026)
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OR13-08 Secretoneurin Modulates Gonadotrope Function Cyclically to Regulate LH Secretion (2025)
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SAT-001 Impact of VCD-induced Menopause on Gonadotrope Transcriptomics Reveals Estrogen-dependent Genes in the GnRH Signaling Pathway (2025)
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SAT-016 Musashi Contributes to the Specification and Maintenance of Distinct Pituitary Cell Lineages. (2025)
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Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models (2025)
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High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes (2025)
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Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model (2025)
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Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B (2025)
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Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice (2025)
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8572 A 30% Maternal Caloric Restriction Alters Expression of Musashi Targets in the Neonatal and Adult Pituitary Proteomes of FVB Mice (2024)
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8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells (2024)
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The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs (2024)
Federal Grants 3 $1,783,459 total
NIH
Co-PI
Sep 2024 - May 2029
NIH
Co-PI
Jul 2021 - Jun 2026
NIH
Co-PI
Sep 2018 - Jun 2025
Control of pituitary cell plasticity through regulated mRNA translation
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Center for Translational Neuroscience NIH Co-Investigator
- Maternal gene regulation in early vertebrate development NIH Co-Investigator
- TEST OF THE RECEPTOR DOMAIN OF CAM KINASE IN VIVO NIH/NIGMS Principal Investigator
- Tropic Roles for Leptin in the Maturation of Somatotropes NIH Co-Principal Investigator
- Post-transcriptional Pathways that Signal Leptin Regulation of Gonadotropes NIH Co-Investigator
Collaboration Network
Top Collaborators
Angus M. MacNicol
University of Arkansas for Medical Sciences
25 shared publications
In database
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
Showing 5 of 25 shared publications
Gwen V. Childs
University of Arkansas for Medical Sciences
21 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B
Showing 5 of 21 shared publications
Angela K. Odle
University of Arkansas for Medical Sciences
19 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
Showing 5 of 19 shared publications
Anessa Haney
University of Arkansas for Medical Sciences
13 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
Showing 5 of 13 shared publications
Alex Lagasse
University of Arkansas for Medical Sciences
13 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
Showing 5 of 13 shared publications
Tiffany K. Miles
Arkansas Children's Hospital
12 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- Leptin: A Metabolic Signal for the Differentiation of Pituitary Cells
Showing 5 of 12 shared publications
Jewel Banik
Stanford University
8 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B
- The Musashi1 RNA-Binding Protein Functions as a Leptin-Regulated Enforcer of Pituitary Cell Fate and Hormone Production
Showing 5 of 8 shared publications
Stephanie D. Byrum
St. Jude Children's Research Hospital
8 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- OR20-03 Leptin-mediated Regulation Of Gene Regulatory Networks In Gonadotropes
- FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes
Showing 5 of 8 shared publications
Ashley Herdman
University of Arkansas for Medical Sciences
8 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes
- 8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells
- High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes
Showing 5 of 8 shared publications
Ulrich Boehm
Saarland University (DE)
6 shared publications
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Musashi as a Regulator of the Follicle-Stimulating Hormone in the Gonadotropes
- OR20-03 Leptin-mediated Regulation Of Gene Regulatory Networks In Gonadotropes
- OR13-08 Secretoneurin Modulates Gonadotrope Function Cyclically to Regulate LH Secretion
Showing 5 of 6 shared publications
Alicja Urbaniak
Cancer Institute (WIA)
5 shared publications
In database
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- Abstract PS18-46: Inhibition of breast cancer stem cells in 2- and 3-dimensional culture by novel salinomycin analogs
- Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model
- Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models
Juchan Lim
Symbiosis International University
5 shared publications
In database
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B
- The Musashi1 RNA-Binding Protein Functions as a Leptin-Regulated Enforcer of Pituitary Cell Fate and Hormone Production
- SAT-016 Musashi Contributes to the Specification and Maintenance of Distinct Pituitary Cell Lineages.
Linda Hardy
University of Arkansas for Medical Sciences
5 shared publications
In database
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B
- The Cell Fate Determinant Musashi Is Controlled Through Dynamic Protein:Protein Interactions
- SAT-016 Musashi Contributes to the Specification and Maintenance of Distinct Pituitary Cell Lineages.
Victoria G Ortega
University of Arkansas for Medical Sciences
5 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- 8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells
- 8572 A 30% Maternal Caloric Restriction Alters Expression of Musashi Targets in the Neonatal and Adult Pituitary Proteomes of FVB Mice
- High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes
Megan R. Reed
University of Arkansas for Medical Sciences
4 shared publications
In database
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Abstract PS18-46: Inhibition of breast cancer stem cells in 2- and 3-dimensional culture by novel salinomycin analogs
- Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model
- Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models
Similar Researchers
Based on overlapping research topics
Angela K. Odle
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