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Confirmed
Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-08-08
X
Xilin Li
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Scientist
Also affiliated: United States Food and Drug Administration (2022–2025); Indiana University Bloomington (2024)
Faculty Researcher
4 h-index
15 pubs
92 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Xilin Li's research investigates the genotoxicity and mutagenicity of various chemical compounds, with a particular focus on nitrosamine impurities in drug substances. Utilizing human cell lines, such as TK6 and HepaRG models, Li evaluates the potential DNA damage and mutagenic effects of these impurities. This work has involved the development and application of methods to assess genotoxicity in both 2D and 3D cell culture systems. Additionally, Li's research extends to the metabolism and toxicity of compounds like cannabidiol, examining its transcriptomic profiles in human and mouse cells. Further studies explore the mechanisms of somatic cell mutation accumulation and the relationship between nonsteroidal anti-inflammatory drug use and pancreatic cancer risk. Li has authored 15 publications and has a h-index of 4, with recent work published in 2025.
Metrics
- h-index: 4
- Publications: 15
- Citations: 92
Selected Publications
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Contribution of cytochrome P450-mediated metabolism to clavulanic acid-induced cytotoxicity in TK6-derived cytochrome P450-overexpressing cell lines (2026)
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Comparative genotoxicity assessment of ortho-phthalaldehyde using human in vitro organotypic airway epithelial cultures and standard in vitro genotoxicity assays (2026)
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Background Mutation Frequencies in <scp>TK6</scp> and <scp>L5178Y</scp> Cells: Implications for Error‐Corrected Sequencing (2025)
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Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models (2025)
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Potential anticancer effects and toxicity of flavones luteolin and apigenin <i>in vivo</i> (2025)
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Review of black cohosh-induced toxicity and adverse clinical effects (2025)
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Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing (2025)
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7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells (2025)
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Comparing the cannabidiol-induced transcriptomic profiles in human and mouse Sertoli cells (2025)
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Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells (2024)
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Optimizing the detection of N-nitrosamine mutagenicity in the Ames test (2024)
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Investigation of cannabidiol-induced cytotoxicity in human hepatic cells (2024)
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Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations (2024)
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Metabolism and liver toxicity of cannabidiol (2024)
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Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells (2024)
Collaboration Network
Top Collaborators
Nan Mei
United States Food and Drug Administration
19 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Optimizing the detection of N-nitrosamine mutagenicity in the Ames test
Showing 5 of 19 shared publications
Si Chen
National Center for Toxicological Research
15 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells
Showing 5 of 15 shared publications
Lei Guo
National Center for Toxicological Research
15 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells
- Metabolism and liver toxicity of cannabidiol
Showing 5 of 15 shared publications
Yuxi Li
National Center for Toxicological Research
13 shared publications
In database
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells
- Metabolism and liver toxicity of cannabidiol
- Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells
Showing 5 of 13 shared publications
Xiaoqing Guo
National Center for Toxicological Research
12 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
Showing 5 of 12 shared publications
Yuan Le
National Center for Toxicological Research
10 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing
- Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells
Showing 5 of 10 shared publications
Robert H. Heflich
National Center for Toxicological Research
8 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Optimizing the detection of N-nitrosamine mutagenicity in the Ames test
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells
Showing 5 of 8 shared publications
Qiangen Wu
National Center for Toxicological Research
7 shared publications
In database
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Metabolism and liver toxicity of cannabidiol
- Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells
- Investigation of cannabidiol-induced cytotoxicity in human hepatic cells
Showing 5 of 7 shared publications
Ji‐Eun Seo
National Center for Toxicological Research
7 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells
Showing 5 of 7 shared publications
Supratim Choudhuri
United States Food and Drug Administration (US)
7 shared publications
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells
- Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells
- Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells
- Investigation of cannabidiol-induced cytotoxicity in human hepatic cells
Showing 5 of 7 shared publications
Aisar Atrakchi
Center for Drug Evaluation and Research (US)
6 shared publications
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Optimizing the detection of N-nitrosamine mutagenicity in the Ames test
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells
Showing 5 of 6 shared publications
Timothy J. McGovern
United States Food and Drug Administration (US)
6 shared publications
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Optimizing the detection of N-nitrosamine mutagenicity in the Ames test
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells
Showing 5 of 6 shared publications
Xiaobo He
United States Food and Drug Administration
5 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Use of Lentivirus‐Based Method for Establishing TK6 Human Cell Lines Expressing Cytochrome P450 and its Applications in Genotoxicity Testing
- Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing
Mugimane G. Manjanatha
National Center for Toxicological Research
5 shared publications
In database
- Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells
- Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells
- Actein contributes to black cohosh extract‐induced genotoxicity in human TK6 cells
- Review of black cohosh-induced toxicity and adverse clinical effects
- Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing
Patrick Cournoyer
United States Food and Drug Administration (US)
5 shared publications
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells
- Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells
- Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells
- Comparing the cannabidiol-induced transcriptomic profiles in human and mouse Sertoli cells
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