S
Si Chen Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Researcher
faculty
40 h-index
191 pubs
4,819 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Si Chen's research focuses on understanding the molecular mechanisms underlying disease and the potential therapeutic effects of natural compounds. Chen has investigated the protective roles of compounds like lupeol against cardiac hypertrophy, examining its impact on key signaling pathways such as TLR4-PI3K-Akt-NF-κB. Further work has explored the function of USP28 in mitigating mitochondrial defects and cardiac dysfunction in diabetic hearts.
Chen's publications also address chemotherapy resistance in colorectal cancer stem cells and the genotoxicity of luteolin, particularly its interaction with cytochrome P450 enzymes (CYP1A1 and CYP1A2) in human lymphoblastoid TK6 cells. This line of research includes the characterization of CYP-overexpressing HepG2 cells for toxicity assessments. Additionally, Chen has examined the roles of long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) in sheep estrous stages and investigated how LINC00941 promotes non-small cell lung cancer progression by regulating VEGFA expression.
With a career marked by 191 publications and 4,729 citations, Si Chen holds an h-index of 39. Chen leads a research group and collaborates with several colleagues at the National Center for Toxicological Research, including Nan Mei, Qiangen Wu, Matthew Bryant, and Xiaobo He, with whom multiple shared publications exist.
Metrics
- h-index: 40
- Publications: 191
- Citations: 4,819
Selected Publications
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Translating in vitro mechanistic findings to in vivo toxicity outcomes: A case study of Usnic acid hepatotoxicity (2026)
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Potential anticancer effects and toxicity of flavones luteolin and apigenin <i>in vivo</i> (2025)
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Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing (2025)
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Comparing the cannabidiol-induced transcriptomic profiles in human and mouse Sertoli cells (2025)
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Metabolism and liver toxicity of cannabidiol (2024)
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Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells (2024)
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Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells (2024)
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Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells (2023)
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The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib (2023)
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Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays (2023)
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Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells (2022)
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Development of benchmark datasets for text mining and sentiment analysis to accelerate regulatory literature review (2022)
Collaboration Network
Top Collaborators
Lei Guo
National Center for Toxicological Research
15 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- Roles of CYP3A4, CYP3A5 and CYP2C8 drug-metabolizing enzymes in cellular cytostatic resistance
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells
Showing 5 of 15 shared publications
Yuxi Li
National Center for Toxicological Research (US)
11 shared publications
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells
- Metabolism and liver toxicity of cannabidiol
- Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells
Showing 5 of 11 shared publications
Xilin Li
Genetic Analysis (Norway) (NO)
9 shared publications
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells
- Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
Showing 5 of 9 shared publications
Nan Mei
National Center for Toxicological Research
8 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- The expression of Phase II drug-metabolizing enzymes in human B-lymphoblastoid TK6 cells
Showing 5 of 8 shared publications
Patrick Cournoyer
United States Food and Drug Administration (US)
5 shared publications
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells
- Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells
- Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells
- Comparing the cannabidiol-induced transcriptomic profiles in human and mouse Sertoli cells
Supratim Choudhuri
Center for Food Safety and Applied Nutrition (US)
5 shared publications
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells
- Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells
- Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells
- Comparing the cannabidiol-induced transcriptomic profiles in human and mouse Sertoli cells
Qiangen Wu
United States Food and Drug Administration
4 shared publications
In database
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Metabolism and liver toxicity of cannabidiol
- Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells
Xuan Qin
Baylor College of Medicine (US)
4 shared publications
- Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Study of the roles of cytochrome P450 (CYPs) in the metabolism and cytotoxicity of perhexiline
- Mechanistic study of pexidartinib-induced toxicity in human hepatic cells
Feng Li
Baylor College of Medicine (US)
4 shared publications
- Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Study of the roles of cytochrome P450 (CYPs) in the metabolism and cytotoxicity of perhexiline
- Mechanistic study of pexidartinib-induced toxicity in human hepatic cells
Xiaobo He
National Center for Toxicological Research
3 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Mechanistic study of pexidartinib-induced toxicity in human hepatic cells
Yuan Le
National Center for Toxicological Research
3 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Actein contributes to black cohosh extract‐induced genotoxicity in human TK6 cells
Matthew Bryant
National Center for Toxicological Research
3 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Mechanistic study of pexidartinib-induced toxicity in human hepatic cells
Qizhu Tang
Zunyi Medical University (CN)
3 shared publications
- Lupeol protects against cardiac hypertrophy via TLR4-PI3K-Akt-NF-κB pathways
- USP28 Serves as a Key Suppressor of Mitochondrial Morphofunctional Defects and Cardiac Dysfunction in the Diabetic Heart
- Corrigendum to “Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting I<i>κ</i>B<i>α</i>/NF<i>κ</i>B and Enhancing Nrf2/HO‐1”
Xiaoqing Guo
United States Food and Drug Administration
3 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Actein contributes to black cohosh extract‐induced genotoxicity in human TK6 cells
Kun Lu
Southwest University (CN)
3 shared publications
- Multi-omics analysis reveals the mechanism of seed coat color formation in Brassica rapa L.
- BnbHLH92a negatively regulates anthocyanin and proanthocyanidin biosynthesis in Brassica napus
- Comparative transcriptome analysis identifies candidate genes related to seed coat color in rapeseed
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