Maria Almeida

Federal Grant PI High Impact

Professor

University of Arkansas for Medical Sciences

faculty

53 h-index 156 pubs 11,388 cited

Research Areas

Bone Metabolism and Diseases Mitochondrial Function and Pathology Geriatric Care and Nursing Homes Estrogen and related hormone effects Bone health and treatments Orthopedic Surgery and Rehabilitation Cellular Mechanics and Interactions Health and Medical Research Impacts

Links

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OverviewAI-generated summary

Maria Almeida is a Professor at the University of Arkansas for Medical Sciences. Her research focuses on the mechanisms of bone loss associated with aging and estrogen deficiency, as well as the role of cellular aging in different types of bone tissue. Almeida investigates the contribution of mitochondrial function, specifically Sirt3, and metabolic changes, such as decreases in NAD+, to age-related bone deterioration.

Her work also examines the involvement of reactive oxygen species in bone cell physiology and pathophysiology. Almeida has secured significant federal funding to support her investigations, including three awards totaling over $1.2 million from the NIH/National Institute on Aging and the NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases. These grants support research into mechanisms of decreased bone formation with aging and the antagonism of RANKL signaling by estrogen in osteoclasts.

Almeida's publication record includes studies on mesenchymal cell types in bone, the impact of Mmp13 deletion on bone mass, and the role of oxidized phospholipids in attenuating age-associated bone loss. She has a highly cited researcher designation, with an h-index of 53 and over 11,000 citations. She actively collaborates with researchers at her institution, including Charles A. O’Brien, Elena Ambrogini, Olivia Reyes‐Castro, and Hayley M. Sabol.

Metrics

h-index: 53
Publications: 156
Citations: 11,388

Selected Publications

IRE1 signaling in osteoprogenitors augments β-catenin activity and physiologic bone accrual (2026) DOI
The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone (2025) DOI
Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness (2025) DOI
CRISPR activation of <i>Tfeb</i> , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength (2024) DOI
Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice (2024) DOI
Single cell RNA sequencing of mesenchymal populations from murine knees reveals distinct pathways altered in age-associated versus post-traumatic osteoarthritis (2024) DOI
Senolytics deplete senescent osteocytes and improve bone health in metastatic breast cancer (2024) DOI
Oestradiol and osteoclast differentiation: Effects on p53 and mitochondrial metabolism (2024) DOI
Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis (2024) DOI
Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone (2024) DOI
A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone (2023) DOI
RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression (2023) DOI
The NAD salvage pathway in mesenchymal cells is indispensable for skeletal development in mice (2023) DOI
ECSIT is essential for RANKL-induced stimulation of mitochondria in osteoclasts and a target for the anti-osteoclastogenic effects of estrogens (2023) DOI
The effect of estradiol during the early stages of osteoclast differentiation is associated with the accumulation of phosphorylated p53 in mitochondria and the inhibition of mitochondrial metabolism (2023) DOI