Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
M
Megan R. Reed
Postdoc
Also affiliated: Virginia Commonwealth University (2016); University of Arkansas Medical Center (2016–2023); Saint Louis University (2019)
13 h-index
42 pubs
667 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Megan R. Reed's research focuses on cancer treatment strategies, particularly for glioblastoma. She has investigated the use of CAR-T therapies in solid tumors, exploring both their opportunities and challenges. Reed's work also includes the development of functional precision medicine pipelines that combine comparative transcriptomics and tumor organoid modeling to identify tailored treatment approaches for glioblastoma. Additionally, her research has explored the anti-glioblastoma activity of specific compounds like monensin and its analogs within organoid models. Her publications also touch upon broader areas of molecular biology, including the genetic encoding of photocaged amino acids for light-controlled protein activity and the development of genetically encoded biosensors for tracking the biosynthesis of semisynthetic antibiotics. Reed's scholarship metrics include an h-index of 15, with 47 total publications and 708 total citations.
Metrics
- h-index: 13
- Publications: 42
- Citations: 667
Positions
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Postdoc 2021–presentUniversity of Arkansas for Medical Sciences Biochemistry and Molecular Biology ORCID
Selected Publications
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Abstract 6545: Characterizing ATF6 activation-driven mechanisms improving ICB efficacy (2026)
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Abstract 5189: Generating EZH2-inhibitor resistant CAR-T cells to sustain function for combination therapy (2026)
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685 EZH2 inhibition impairs CD8+ CAR-T cell persistence (2025)
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691 ATF6 activation promotes ICB response in melanoma (2025)
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Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models (2025)
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Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model (2025)
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EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma (2025)
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Abstract 1488: DNA polymerase kappa slows replication fork speed by promoting fork reversal in glioblastoma (2025)
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1132 Enhancing melanoma therapy efficacy by protecting EZH2 activity in T cells (2024)
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538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response (2024)
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Abstract 1333 DNA polymerase kappa (Pol k) promotes replication gap suppression by preventing PrimPol mediated repriming and safeguards genomic stability in Glioblastoma Multiforme (GBM) (2024)
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Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity (2024)
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536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma (2023)
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Abstract LB041: EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma (2023)
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CAR-T Therapies in Solid Tumors: Opportunities and Challenges (2023)
Collaboration Network
Top Collaborators
Robert L. Eoff
Cancer Institute (WIA)
23 shared publications
In database
- LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation
- Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
- A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
Showing 5 of 23 shared publications
Alan J. Tackett
University of Arkansas for Medical Sciences
15 shared publications
In database
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models
Showing 5 of 15 shared publications
Billie Heflin
University of Arkansas for Medical Sciences
15 shared publications
In database
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models
- Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer
Showing 5 of 15 shared publications
Leena Maddukuri
University of Arkansas for Medical Sciences
12 shared publications
In database
- Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
- A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma
- Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
Showing 5 of 12 shared publications
Brian Koss
University of Arkansas for Medical Sciences
11 shared publications
In database
- CAR-T Therapies in Solid Tumors: Opportunities and Challenges
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract LB041: EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
- Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity
Showing 5 of 11 shared publications
Daniel Fil
University of Arkansas for Medical Sciences
10 shared publications
In database
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
- Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
Showing 5 of 10 shared publications
Amit Ketkar
University of Arkansas for Medical Sciences
9 shared publications
In database
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
- Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
Showing 5 of 9 shared publications
Alicja Urbaniak
Cancer Institute (WIA)
8 shared publications
In database
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways
- Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models
- Novel Salinomycin Analogs Show Improved Selectivity Towards Breast Cancer Stem Cells
Showing 5 of 8 shared publications
Timothy C. Chambers
University of Arkansas for Medical Sciences
8 shared publications
In database
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways
- Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models
- Novel Salinomycin Analogs Show Improved Selectivity Towards Breast Cancer Stem Cells
Showing 5 of 8 shared publications
Maroof K. Zafar
University of Arkansas for Medical Sciences
7 shared publications
In database
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
- Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
Showing 5 of 7 shared publications
Adam Huczyński
Adam Mickiewicz University in Poznań (PL)
7 shared publications
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models
- Novel Salinomycin Analogs Show Improved Selectivity Towards Breast Cancer Stem Cells
- Abstract PS18-46: Inhibition of breast cancer stem cells in 2- and 3-dimensional culture by novel salinomycin analogs
Showing 5 of 7 shared publications
Angus M. MacNicol
Cancer Institute (WIA)
7 shared publications
In database
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models
- Novel Salinomycin Analogs Show Improved Selectivity Towards Breast Cancer Stem Cells
- Abstract PS18-46: Inhibition of breast cancer stem cells in 2- and 3-dimensional culture by novel salinomycin analogs
Showing 5 of 7 shared publications
Analiz Rodriguez
University of Arkansas for Medical Sciences
7 shared publications
In database
- CAR-T Therapies in Solid Tumors: Opportunities and Challenges
- A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- CAR T-cells to treat brain tumors
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
Showing 5 of 7 shared publications
Jacob L Edmondson
University of Arkansas for Medical Sciences
6 shared publications
In database
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
- Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
- 1132 Enhancing melanoma therapy efficacy by protecting EZH2 activity in T cells
- 691 ATF6 activation promotes ICB response in melanoma
Showing 5 of 6 shared publications
Justin Leung
University of Arkansas for Medical Sciences (US)
5 shared publications
- LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation
- Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
- DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
- Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
- Deletion of putative xenobiotic response elements (XREs) in hpol κ alters the replication stress response and overall genomic instability in glioblastoma cells
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