Valentina K. Todorova

Assistant Professor

University of Arkansas for Medical Sciences

faculty

Internal Med, College of Medicine

18 h-index 39 pubs 775 cited

Research Areas

Cancer Treatment and Pharmacology MicroRNA in disease regulation Extracellular vesicles in disease Pharmacological Effects and Toxicity Studies Immune Response and Inflammation Cancer-related molecular mechanisms research Cardiovascular Function and Risk Factors Meta-analysis and systematic reviews

Links

Research Group UAMS TRI Profile

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OverviewAI-generated summary

Valentina K. Todorova's research focuses on identifying and validating biomarkers for predicting treatment response and toxicity in cancer patients. Her work has investigated circulating exosomal microRNAs and protein profiles as potential indicators of response to neoadjuvant chemotherapy in breast cancer and as markers for hepatitis B virus-related hepatocellular carcinoma. She has also studied neutrophil biomarkers and metabolic phenotypes to predict doxorubicin-induced cardiotoxicity in breast cancer patients, a significant side effect of anthracycline chemotherapy. Additionally, her research has explored the transcriptomic information obtainable from formalin-fixed paraffin-embedded heart tissue for studying chemotherapy-induced cardiotoxicity. Todorova has published 39 papers, accumulating 775 citations, and holds an h-index of 18. She collaborates with researchers at the University of Arkansas for Medical Sciences, including Jeanne Y. Wei, Dr. Stephanie Byrum, and Allen Gies, as well as Nathan S. Reyna from Ouachita Baptist University.

Metrics

h-index: 18
Publications: 39
Citations: 775

Selected Publications

Neutrophil Biomarkers Can Predict Cardiotoxicity of Anthracyclines in Breast Cancer (2024) DOI
RNA sequencing of formalin fixed paraffin-embedded heart tissue provides transcriptomic information about chemotherapy-induced cardiotoxicity (2024) DOI
Abstract 3625: Metabolic phenotypes of doxorubicin-induced cardiotoxicity in breast cancer patients (2024) DOI
Review of: "Effect of neutrophil-to-lymphocyte ratio and vitamin D3 levels on the pathological complete response after neoadjuvant treatment in TNBC and HER2-positive early breast cancer – results of a prospective study" (2023) DOI
Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells (2023) DOI
Circulating Exosomal microRNAs as Predictive Biomarkers of Neoadjuvant Chemotherapy Response in Breast Cancer (2022) DOI

Grants & Funding

Center for Studies of Host Response to Cancer Therapy NIH Co-Investigator
No FP attached UAMS Executive Breast Committee Principal Investigator
Advancing Breast Cancer Treatment through Suppression of Chemo-Resistance UAMS Executive Breast Committee Principal Investigator
Arkansas Claude Pepper Older Americans Independence Center at UAMS NIH Co-Investigator
TCIA Sustainment and Scalability - Platforms for Quantitative Imaging Informatics in Precision Medicine NIH Co-Investigator
Advancing Breast Cancer Treatment through Suppression of Chemo-Resistance UAMS Executive Breast Committee Principal Investigator
Dietary glutamine and protection against doxorubicin and cyclophosphamide toxicity Susan G. Komen for the Cure Principal Investigator
No FP attached UAMS Executive Breast Committee Principal Investigator