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Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
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2026-10-06
K
Kimberly J. Krager
This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.
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Also affiliated: University of Iowa (2003–2015); Arkansas Children's Hospital (2017); University of Arkansas Medical Center (2021); University of Iowa Hospitals and Clinics (2007); University of Iowa Health Care (2003)
21 h-index
76 pubs
3,034 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Kimberly J. Krager investigates the molecular mechanisms underlying bone loss, particularly in the context of aging and estrogen deficiency. Her research has explored the role of mitochondrial Sirtuin 3 (Sirt3) in age-related bone loss and bone loss due to estrogen deficiency. Krager has also studied the impact of transferrin receptor 1-mediated iron uptake on bone mass, examining its effects via osteoclast mitochondria and cytoskeleton. Her work has extended to the effects of ionizing radiation on bone health, specifically in young adult male mice, where she observed activation of mitochondrial function in osteoclasts leading to bone loss. Further research has examined simulated galactic cosmic rays' impact on osteoclast mitochondrial metabolism, osteoclastogenesis, and trabecular bone loss.
Beyond bone health, Krager's research has touched upon radiation-induced heart disease, investigating the role of Toll-like receptor 4 (TLR4). She has also examined the sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in various mouse tissues, including the heart, small intestine, and skin. Additionally, her work has included investigating the mechanism of parthenolide-induced ferroptosis in hepatocellular carcinoma cells.
Krager's scholarship metrics include an h-index of 21, with 73 total publications and 2,888 total citations. She is recognized as a highly cited researcher. Her key collaborators include Nükhet Aykin‐Burns, Francesca V. LoBianco, Ha‐Neui Kim, and Marjan Boerma, with whom she has multiple shared publications.
Metrics
- h-index: 21
- Publications: 76
- Citations: 3,034
Selected Publications
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Mitochondrial-targeted SS-31 peptide attenuates radiation-induced cardiomyocyte senescence (2026)
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Assessing Pain Linked to High Metabolic and Glycolytic Shift in Neurofibromatosis Type 1 (NF1) Patients by Using a Bioenergetic Biomarker: A Pilot Study (2026)
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Beneficial effects of an indole derivative melatonin analogue in estrogen receptor positive breast cancer (2026)
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SIRT3–IDH2 axis is a target of dietary fructose: implication of IDH2 as a key player in dietary carcinogen toxicity in mice colon (2025)
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Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models (2025)
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Enhancing Rectal Cancer Radiosensitivity and Gut Protection through Methionine Restriction (2025)
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SIRT3-IDH2 axis is a target of dietary fructose: implication of IDH2 as a key player in dietary carcinogen toxicity in mice colon (2025)
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Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects (2023)
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TLR4—A Pertinent Player in Radiation-Induced Heart Disease? (2023)
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Abstract No. 106 Where are Women in Academic Interventional Radiology? (2023)
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Effect of Sirt3 on hippocampal MnSOD activity, mitochondrial function, physiology, and cognition in an aged murine model (2023)
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Effects of Whole and Partial Heart Irradiation on Collagen, Mast Cells, and Toll-like Receptor 4 in the Mouse Heart (2023)
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Effect of Sirt3 on Hippocampal MnSOD Activity, Mitochondrial Function, Physiology, And Cognition in an Aged Murine Model (2022)
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Effect of Sirt3 on Hippocampal MnSOD Activity, Mitochondrial Function, Physiology, and Cognition in an Aged Murine Model (2022)
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Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice (2022)
Collaboration Network
Top Collaborators
Nükhet Aykin‐Burns
University of Arkansas for Medical Sciences
48 shared publications
In database
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
- Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors
- Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Radiation-Induced Alterations in Mitochondria of the Rat Heart
Showing 5 of 48 shared publications
Martin Hauer‐Jensen
University of Arkansas for Medical Sciences
14 shared publications
In database
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
- Radiation-Induced Alterations in Mitochondria of the Rat Heart
- Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction
- In VitroToxicity and Epigenotoxicity of Different Types of Ambient Particulate Matter
- A Tocotrienol-Enriched Formulation Protects against Radiation-Induced Changes in Cardiac Mitochondria without Modifying Late Cardiac Function or Structure
Showing 5 of 14 shared publications
Marjan Boerma
University of Arkansas for Medical Sciences
10 shared publications
In database
- Radiation-Induced Alterations in Mitochondria of the Rat Heart
- TLR4—A Pertinent Player in Radiation-Induced Heart Disease?
- A Tocotrienol-Enriched Formulation Protects against Radiation-Induced Changes in Cardiac Mitochondria without Modifying Late Cardiac Function or Structure
- Characterization of Transgenic Gfrp Knock-In Mice: Implications for Tetrahydrobiopterin in Modulation of Normal Tissue Radiation Responses
- Dietary Methionine Supplementation Exacerbates Gastrointestinal Toxicity in a Mouse Model of Abdominal Irradiation
Showing 5 of 10 shared publications
Francesca V. LoBianco
University of Arkansas for Medical Sciences
10 shared publications
In database
- Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells
- The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury
- Effect of Sirt3 on hippocampal MnSOD activity, mitochondrial function, physiology, and cognition in an aged murine model
- Assessment of Cellular Oxidation using a Subcellular Compartment-Specific Redox-Sensitive Green Fluorescent Protein
- Abstract No. 428 Parthenolide induces thiol oxidation-mediated cytotoxicity in human and rat hepatocellular carcinoma cell lines
Showing 5 of 10 shared publications
Snehalata A. Pawar
SUNY Upstate Medical University (US)
8 shared publications
- Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction
- TLR4—A Pertinent Player in Radiation-Induced Heart Disease?
- Characterization of Transgenic Gfrp Knock-In Mice: Implications for Tetrahydrobiopterin in Modulation of Normal Tissue Radiation Responses
- Small animal models of localized heart irradiation
- Effects of Whole and Partial Heart Irradiation on Collagen, Mast Cells, and Toll-like Receptor 4 in the Mouse Heart
Showing 5 of 8 shared publications
Rupak Pathak
University of Arkansas for Medical Sciences
7 shared publications
In database
- In VitroToxicity and Epigenotoxicity of Different Types of Ambient Particulate Matter
- Characterization of Transgenic Gfrp Knock-In Mice: Implications for Tetrahydrobiopterin in Modulation of Normal Tissue Radiation Responses
- Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
- Modulation of Radiation Response by the Tetrahydrobiopterin Pathway
- Dietary Methionine Supplementation Exacerbates Gastrointestinal Toxicity in a Mouse Model of Abdominal Irradiation
Showing 5 of 7 shared publications
Vijayalakshmi Sridharan
University of Arkansas for Medical Sciences
7 shared publications
In database
- Radiation-Induced Alterations in Mitochondria of the Rat Heart
- TLR4—A Pertinent Player in Radiation-Induced Heart Disease?
- A Tocotrienol-Enriched Formulation Protects against Radiation-Induced Changes in Cardiac Mitochondria without Modifying Late Cardiac Function or Structure
- Characterization of Transgenic Gfrp Knock-In Mice: Implications for Tetrahydrobiopterin in Modulation of Normal Tissue Radiation Responses
- Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin
Showing 5 of 7 shared publications
Antiño R. Allen
University of Arkansas for Medical Sciences
7 shared publications
In database
- Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells
- Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice
- Behavioral Effects of Focal Irradiation in a Juvenile Murine Model
- Effect of Sirt3 on hippocampal MnSOD activity, mitochondrial function, physiology, and cognition in an aged murine model
- The sex-dependent impact of SIRT3 on cognition
Showing 5 of 7 shared publications
Ha‐Neui Kim
Central Arkansas Veterans Healthcare System
6 shared publications
In database
- Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors
- Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
- Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
- Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice
- Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice
Showing 5 of 6 shared publications
Haibo Zhao
Southern California Institute for Research and Education (US)
5 shared publications
- Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Author response: Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- The Murine Osteoclasts Lacking Transferrin Receptor 1 have Altered Mitochondrial Metabolism, Cytoskeletal Organization and Increased Trabecular Bone Mass
Samuel G. Mackintosh
University of Arkansas for Medical Sciences
5 shared publications
In database
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Author response: Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Abstract 1029: Epigenetic control of tumor-infiltrating lymphocyte metabolic-exhaustion
César M. Compadre
University of Arkansas for Medical Sciences
4 shared publications
In database
- Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans)
- Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells
- Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
- Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity
Qiang Fu
University of Arkansas for Medical Sciences
4 shared publications
In database
- Characterization of Transgenic Gfrp Knock-In Mice: Implications for Tetrahydrobiopterin in Modulation of Normal Tissue Radiation Responses
- Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
- De Novo Biosynthesis of Tetrahydrobiopterin is Critical in Protecting against Ionizing Radiation
- The Role of Tetrahydrobiopterin (BH4) Bioavailability in Radiation-Induced Skin Injury
Stepan B. Melnyk
Arkansas Children's Hospital (US)
4 shared publications
- The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes
- Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction
- A Tocotrienol-Enriched Formulation Protects against Radiation-Induced Changes in Cardiac Mitochondria without Modifying Late Cardiac Function or Structure
- Trifluoperazine inhibits acetaminophen-induced hepatotoxicity and hepatic reactive nitrogen formation in mice and in freshly isolated hepatocytes
Daohong Zhou
University of Florida (US)
4 shared publications
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
- Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice
- Investigating the effects of hyperbaric oxygen on mitochondrial function of endothelial progenitor cells.
- Hem1 promotes osteoclast fusion and bone resorption in mice
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