Dennis Province

Researcher

UAMS

Unknown Researcher

2 h-index 9 pubs 15 cited

Research Areas

Biomedical Subjects

OverviewAI-generated summary

Dennis Province's research investigates mechanisms underlying disease progression, utilizing both in vivo models and advanced microphysiological systems. His work includes studying the progression of calcific aortic valve disease, employing a three-dimensional valve-on-chip system to identify factors such as cell cycle progression, cholesterol metabolism, and protein homeostasis. Province also examines the protective effects of Factor XI inhibition in sepsis models, specifically using abelacimab in baboons challenged with Staphylococcus aureus. Further research explores how anthrax toxins impact sepsis-induced coagulopathy and endothelial dysfunction in baboons. Additionally, his work touches on proteome turnover dynamics to uncover E3 ligases influencing T-cell persistence during exhaustion and investigates circulating extracellular vesicle protein biomarkers for early cancer detection, including diffuse large B-cell lymphoma and high-grade serous ovarian cancer. He also studies the intracellular tracking and protein interactomes of hemopexin in human immune and liver cell models.

Metrics

h-index: 2
Publications: 9
Citations: 15

Selected Publications

Proteomic consequences of male mate preference learning and female phenotype in the butterfly <i>Bicyclus anynana</i> (2026)

bioRxiv (Cold Spring Harbor Laboratory) DOI OpenAlex
Scaling of Neuronal Growth and Excitability Through Separable mTORC1 and mTORC2 Pathways (2026)

bioRxiv (Cold Spring Harbor Laboratory) DOI OpenAlex
A Suspension-Trapping Protocol for Bottom-Up Proteomics Sample Preparation (2026)

BIO-PROTOCOL DOI OpenAlex
Circulating Extracellular Vesicle Protein Biomarkers for the Early Detection of High-Grade Serous Ovarian Cancer (2026)

Molecular & Cellular Proteomics 2 citations DOI OpenAlex
Tracking hemopexin intracellularly and defining hemopexin protein “interactomes” in human immune and liver cell models (2025)

Frontiers in Physiology DOI OpenAlex
277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion (2025)

Regular and Young Investigator Award Abstracts DOI OpenAlex
Anthrax toxins exacerbate sepsis-induced coagulopathy and endothelial dysfunction in a baboon model of anthrax (2025)

Journal of Thrombosis and Haemostasis DOI OpenAlex
Protective effects of factor XI inhibition by abelacimab in a baboon model of live Staphylococcus aureus sepsis (2025)

Journal of Thrombosis and Haemostasis 2 citations DOI OpenAlex
Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion (2025)

SSRN Electronic Journal DOI OpenAlex
Abstract B017: MicroRNA and proteomic analyses of plasma extracellular vesicles detect diffuse large B-cell lymphoma (2024)

Clinical Cancer Research DOI OpenAlex
319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion (2024)

Regular and Young Investigator Award Abstracts DOI OpenAlex
A three-dimensional valve-on-chip microphysiological system implicates cell cycle progression, cholesterol metabolism and protein homeostasis in early calcific aortic valve disease progression (2024)

Acta Biomaterialia 10 citations DOI OpenAlex
Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics (2020)

Drug Metabolism and Disposition 12 citations DOI OpenAlex
DISINFECTION OF B. SUBTILIS CELLS IN SUSPENSION USING ULTRAVIOLET LIGHT EMITTING DIODES (LEDS) IN THE PRESENCE OF TiO[sub 2] (2011)

AIP conference proceedings 1 citation DOI OpenAlex