Dennis Province

Researcher

Last publication 2026 Last refreshed 2026-05-16

unknown

4 h-index 9 pubs 29 cited

Research Areas

OverviewAI-generated summary

Dennis Province's research investigates mechanisms underlying disease progression and potential diagnostic markers. His recent publications explore the role of extracellular vesicles in detecting high-grade serous ovarian cancer and diffuse large B-cell lymphoma, utilizing proteomic and microRNA analyses. He has also studied proteome turnover dynamics to identify factors enhancing T-cell persistence during exhaustion and examined how anthrax toxins impact sepsis-induced coagulopathy and endothelial dysfunction in baboon models.

Further work includes investigating cell cycle progression and cholesterol metabolism in calcific aortic valve disease using a valve-on-chip system. Province also studies the protective effects of factor XI inhibition in a baboon model of Staphylococcus aureus sepsis and tracks hemopexin intracellularly, defining its protein interactomes in human immune and liver cells. His work involves collaborations with Rick D. Edmondson, Brian Koss, Samuel G. Mackintosh, and Lora J. Rogers at the University of Arkansas for Medical Sciences.

Metrics

h-index: 4
Publications: 9
Citations: 29

Selected Publications

Circulating Extracellular Vesicle Protein Biomarkers for the Early Detection of High-Grade Serous Ovarian Cancer (2026)

DOI OpenAlex
Tracking hemopexin intracellularly and defining hemopexin protein “interactomes” in human immune and liver cell models (2025)

DOI OpenAlex
277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion (2025)

DOI OpenAlex
Anthrax toxins exacerbate sepsis-induced coagulopathy and endothelial dysfunction in a baboon model of anthrax (2025)

DOI OpenAlex
Protective effects of factor XI inhibition by abelacimab in a baboon model of live Staphylococcus aureus sepsis (2025)

2 citations DOI OpenAlex
Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion (2025)

DOI OpenAlex
Abstract B017: MicroRNA and proteomic analyses of plasma extracellular vesicles detect diffuse large B-cell lymphoma (2024)

DOI OpenAlex
319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion (2024)

DOI OpenAlex
A three-dimensional valve-on-chip microphysiological system implicates cell cycle progression, cholesterol metabolism and protein homeostasis in early calcific aortic valve disease progression (2024)

8 citations DOI OpenAlex