Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-09
Lin‐Xi Li
Federal Grant PI
Associate Professor
Also affiliated: University of Minnesota (2010–2011); University of Arkansas Medical Center (2024); University of California, Davis (2012–2017)
Microbiology & Immunology, College of Medicine
13 h-index
34 pubs
731 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Lin-Xi Li studies the mechanisms of immune protection against bacterial infections, with a particular focus on Chlamydia.
As Principal Investigator on two NIH grants totaling over $558,000, Li is investigating the role of memory CD4 T cells in mediating immunity to Chlamydia and exploring early protective immune responses to this pathogen. His research group utilizes mouse models to understand the complex interactions between host immunity and microbial infections.
Li's work has resulted in publications examining T cell subsets, B cell contributions to immunity, and the signaling pathways that regulate immune responses. Collaborations with researchers at the University of Arkansas for Medical Sciences, including Miguel A. B. Mercado, Yejin Kim, J. Tucker Andrews, and Lu Huang, contribute to his research network. Li has an h-index of 13 and has published 34 papers with over 700 citations.
Metrics
- h-index: 13
- Publications: 34
- Citations: 731
Positions
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Associate Professor publications 2016–2026University of Arkansas for Medical Sciences Microbiology & Immunology, College of Medicine Institutional directory
Selected Publications
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CXCR6 marks polyfunctional effector CD4 T cells required for anti- Chlamydia immunity in the female reproductive tract (2026)
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β-glucan-induced monocyte-derived alveolar macrophages confer protection against Mycobacterium tuberculosis 4395 (2025)
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The roles of TGFb signaling in CD4 T cell responses to Chlamydia infection in the female reproductive tract 9284 (2025)
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CXCR6+ polyfunctional CD4 T cells are essential for protective immunity against Chlamydia in the female reproductive tract (2024)
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Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis (2024)
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BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia (2024)
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P2X7 -Mediated Antigen-Independent Activation of CD8 + T Cells Promotes Salt-Sensitive Hypertension (2024)
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BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia (2023)
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Transcription factor Bhlhe40 plays a protective role during intravaginal Chlamydia muridarum infection in mice (2023)
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Metabolism and ontogeny of alveolar macrophages contribute to peripheral trained immunity and confer protection against Mycobacterium tuberculosis (2023)
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IFNγ and Antibody Synergize To Enhance Protective Immunity against Chlamydia Dissemination and Female Reproductive Tract Reinfections (2022)
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IFNγ and antibody synergize to enhance protective immunity against Chlamydia dissemination and female reproductive tract reinfections (2022)
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The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension (2022)
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Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10 (2021)
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Innate IFN-γ Is Essential for Systemic Chlamydia muridarum Control in Mice, While CD4 T Cell-Dependent IFN-γ Production Is Highly Redundant in the Female Reproductive Tract (2020)
Federal Grants 2 $558,240 total
NIH
Contact PI
May 2024 - Mar 2027
NIH
Contact PI
May 2018 - Apr 2024
Mechanisms of memory CD4 T cell-mediated immune protection against Chlamydia
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- T cell homing to the kidney contributes to salt retention and blood pressure regulation - Continuation NIH/Nat. Heart, Lung & Blood Institute Co-Investigator
- Mechanisms of memory CD4 T cell-mediated immune protection against Chlamydia - Continuation NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
Collaboration Network
Top Collaborators
Miguel A. B. Mercado
University of Arkansas for Medical Sciences
9 shared publications
In database
- Innate IFN-γ Is Essential for Systemic Chlamydia muridarum Control in Mice, While CD4 T Cell-Dependent IFN-γ Production Is Highly Redundant in the Female Reproductive Tract
- Antibody, but not B‐cell–dependent antigen presentation, plays an essential role in preventing Chlamydia systemic dissemination in mice
- IFNγ and Antibody Synergize To Enhance Protective Immunity against Chlamydia Dissemination and Female Reproductive Tract Reinfections
- BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia
- Innate IFNγ is essential for systemic Chlamydia control while CD4 T cell-dependent IFNγ production is highly redundant in the female reproductive tract
Showing 5 of 9 shared publications
Lu Huang
University of Arkansas for Medical Sciences
8 shared publications
In database
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis
- P2X7 -Mediated Antigen-Independent Activation of CD8 + T Cells Promotes Salt-Sensitive Hypertension
- BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia
- Metabolism and ontogeny of alveolar macrophages contribute to peripheral trained immunity and confer protection against Mycobacterium tuberculosis
Showing 5 of 8 shared publications
Yejin Kim
University of Arkansas for Medical Sciences
6 shared publications
In database
- BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia
- Transcription factor Bhlhe40 plays a protective role during intravaginal Chlamydia muridarum infection in mice
- BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia
- CXCR6+ polyfunctional CD4 T cells are essential for protective immunity against Chlamydia in the female reproductive tract
- The roles of TGFb signaling in CD4 T cell responses to Chlamydia infection in the female reproductive tract 9284
Showing 5 of 6 shared publications
Priyangi A. Malaviarachchi
University of Arkansas for Medical Sciences
5 shared publications
In database
- Innate IFN-γ Is Essential for Systemic Chlamydia muridarum Control in Mice, While CD4 T Cell-Dependent IFN-γ Production Is Highly Redundant in the Female Reproductive Tract
- Antibody, but not B‐cell–dependent antigen presentation, plays an essential role in preventing Chlamydia systemic dissemination in mice
- IFNγ and Antibody Synergize To Enhance Protective Immunity against Chlamydia Dissemination and Female Reproductive Tract Reinfections
- Innate IFNγ is essential for systemic Chlamydia control while CD4 T cell-dependent IFNγ production is highly redundant in the female reproductive tract
- IFNγ and antibody synergize to enhance protective immunity against Chlamydia dissemination and female reproductive tract reinfections
J. Tucker Andrews
University of Arkansas for Medical Sciences
5 shared publications
In database
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis
- P2X7 -Mediated Antigen-Independent Activation of CD8 + T Cells Promotes Salt-Sensitive Hypertension
- Metabolism and ontogeny of alveolar macrophages contribute to peripheral trained immunity and confer protection against Mycobacterium tuberculosis
- β-glucan-induced monocyte-derived alveolar macrophages confer protection against Mycobacterium tuberculosis 4395
Stephen J. McSorley
University of California, Davis (US)
4 shared publications
- Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential
- Antibody, but not B‐cell–dependent antigen presentation, plays an essential role in preventing Chlamydia systemic dissemination in mice
- CCR7 Deficiency Allows Accelerated Clearance of Chlamydia from the Female Reproductive Tract
- Adhesion Molecules Associated with Female Genital Tract Infection
Wuying Du
University of Arkansas for Medical Sciences
4 shared publications
In database
- Innate IFN-γ Is Essential for Systemic Chlamydia muridarum Control in Mice, While CD4 T Cell-Dependent IFN-γ Production Is Highly Redundant in the Female Reproductive Tract
- IFNγ and Antibody Synergize To Enhance Protective Immunity against Chlamydia Dissemination and Female Reproductive Tract Reinfections
- Innate IFNγ is essential for systemic Chlamydia control while CD4 T cell-dependent IFNγ production is highly redundant in the female reproductive tract
- IFNγ and antibody synergize to enhance protective immunity against Chlamydia dissemination and female reproductive tract reinfections
Jessica I. Gann
University of Arkansas for Medical Sciences
3 shared publications
In database
- Innate IFN-γ Is Essential for Systemic Chlamydia muridarum Control in Mice, While CD4 T Cell-Dependent IFN-γ Production Is Highly Redundant in the Female Reproductive Tract
- IFNγ and Antibody Synergize To Enhance Protective Immunity against Chlamydia Dissemination and Female Reproductive Tract Reinfections
- Innate IFNγ is essential for systemic Chlamydia control while CD4 T cell-dependent IFNγ production is highly redundant in the female reproductive tract
Shengyu Mu
University of Arkansas for Medical Sciences
3 shared publications
In database
- The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
- Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis
- P2X7 -Mediated Antigen-Independent Activation of CD8 + T Cells Promotes Salt-Sensitive Hypertension
Charles M. Quick
University of Arkansas for Medical Sciences
3 shared publications
In database
- BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia
- Transcription factor Bhlhe40 plays a protective role during intravaginal Chlamydia muridarum infection in mice
- BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia
Rachel S. Palmer
University of Arkansas for Medical Sciences
3 shared publications
In database
- BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia
- Transcription factor Bhlhe40 plays a protective role during intravaginal Chlamydia muridarum infection in mice
- BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia
Qiang Li
University of Arkansas for Medical Sciences (US)
3 shared publications
- BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia
- BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia
- CXCR6+ polyfunctional CD4 T cells are essential for protective immunity against Chlamydia in the female reproductive tract
Jamal Qualai
IrsiCaixa (ES)
2 shared publications
- Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential
- Adhesion Molecules Associated with Female Genital Tract Infection
Jon Cantero-Pérez
IrsiCaixa (ES)
2 shared publications
- Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential
- Adhesion Molecules Associated with Female Genital Tract Infection
Lauro Sumoy
Institute of Predictive and Personalized Medicine of Cancer (ES)
2 shared publications
- Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential
- Adhesion Molecules Associated with Female Genital Tract Infection
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