Match tier
Confirmed
Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-08-20
N
Nicholas P. Greene
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Federal Grant PI
High Impact
Associate Professor
Also affiliated: University of South Carolina (2006); Texas A&M University System (2012–2016); Michigan Public Health Institute (2009); Fred Hutch Cancer Center (2019); Texas A&M Health Science Center (2012); Development Fund (2007); Stavros (2015); Crouse Hospital (2009–2018); Arkansas Department of Health (2017); University of Virginia (2011–2013); Southern Illinois University Edwardsville (2016); Texas A&M University (2007–2016); SPX Corporation (United States) (2007)
Faculty Researcher
29 h-index
180 pubs
3,973 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Nicholas P. Greene's research investigates the molecular and physiological mechanisms underlying skeletal muscle atrophy and weakness, with a particular focus on conditions such as cancer cachexia and disuse atrophy. His work has explored the role of mitochondrial stress in muscle weakness preceding atrophy in cancer cachexia and has identified molecular signatures associated with exercise adaptation and aging in skeletal muscle. Greene has also examined sex-based differences in the development of disuse atrophy and cancer cachexia, noting potentially exacerbated catabolic signaling in female mice and distinct transcriptional disruptions in female skeletal muscle during cancer cachexia onset.
His federally funded research, supported by a $313,850 grant from the NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases, focuses on developing targeted approaches for the prevention of cancer cachexia. Greene's publication record includes 180 works with an h-index of 29 and over 3,930 citations, reflecting significant contributions to his field. He collaborates extensively with researchers at the University of Arkansas at Fayetteville, including Francielly Morena da Silva, Tyrone A. Washington, Ana Regina Cabrera, and Eleanor R. Schrems, with whom he has co-authored numerous publications.
Metrics
- h-index: 29
- Publications: 180
- Citations: 3,973
Selected Publications
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The Age‐Dependent Resident Myonuclear Multi‐Omic Response to an Acute Skeletal Muscle Hypertrophic Stimulus in Mice (2026)
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Exercise-induced antioxidant programming in oxidative muscle: a critical IL1β-NBR1-p62 axis (2026)
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Skeletal muscle methylome-transcriptome disruptions during the onset and progression of colorectal cancer-induced cachexia (2025)
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The Age-Dependent Resident Myonuclear Multi-Omic Response to a Skeletal Muscle Hypertrophic Stimulus (2025)
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Transcriptomic analysis demonstrates moderators of muscle quality are altered in age-related sarcopenic obesity (2025)
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Promoting mitochondrial fusion is protective against cancer-induced muscle detriments in males and females (2025)
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Landscape of clinical trials in cancer cachexia: assessment of trends from 1995–2024 (2025)
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Mitochondrial-targeted plastoquinone therapy prevents early onset muscle weakness that occurs before atrophy during ovarian cancer (2025)
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Sustained Accumulation of Molecular Clock Suppressors Period 1 and Period 2 Promotes C2C12 Myotube Atrophy Through an Autocrine-Mediated Mechanism With Relevance to Androgen Deprivation-Induced Limb Muscle Mass Loss (2025)
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Global mitophagy inhibition via BNIP3 ablation is not sufficient to alleviate skeletal muscle impairments in male and female tumor-bearing mice (2025)
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Myocellular adaptations to short‐term weighted wheel‐running exercise are largely conserved during C26‐tumour induction in male and female mice (2025)
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Landscape of Clinical Trials in Cancer Cachexia: Assessment of Trends From 1995-2024 (2025)
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The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth (2024)
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Transcriptional analysis of cancer cachexia: conserved and unique features across preclinical models and biological sex (2024)
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Mitochondrial-targeted plastoquinone therapy ameliorates early onset muscle weakness that precedes ovarian cancer cachexia in mice (2024)
Federal Grants 1 $313,850 total
NIH
Contact PI
Jul 2020 - Jun 2026
DEVELOPMENT OF TARGETED APPROACHES IN PREVENTION OF CANCER-CACHEXIA
Collaboration Network
Top Collaborators
Francielly Morena da Silva
University of Arkansas at Fayetteville
24 shared publications
In database
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Inflammation o'clock: interactions of circadian rhythms with inflammation‐induced skeletal muscle atrophy
Showing 5 of 24 shared publications
Tyrone A. Washington
University of Arkansas at Fayetteville
23 shared publications
In database
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- Exercise Counteracts the Deleterious Effects of Cancer Cachexia
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
Showing 5 of 23 shared publications
Ana Regina Cabrera
University of Arkansas at Fayetteville
22 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- The mechanosensitive gene <i>arrestin domain containing 2</i> regulates myotube diameter with direct implications for disuse atrophy with aging
Showing 5 of 22 shared publications
Eleanor R. Schrems
University of Arkansas at Fayetteville
18 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
Showing 5 of 18 shared publications
Kevin A. Murach
University of Arkansas at Fayetteville
18 shared publications
In database
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- Exercise Counteracts the Deleterious Effects of Cancer Cachexia
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Inflammation o'clock: interactions of circadian rhythms with inflammation‐induced skeletal muscle atrophy
- The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
Showing 5 of 18 shared publications
Seongkyun Lim
University of Arkansas at Fayetteville
17 shared publications
In database
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
Showing 5 of 17 shared publications
Megan E. Rosa‐Caldwell
University of Arkansas at Fayetteville
15 shared publications
In database
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
Showing 5 of 15 shared publications
Ronald G. Jones
University of Arkansas at Fayetteville
11 shared publications
In database
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
- Muscle weakness and mitochondrial stress occur before severe metastasis in a novel mouse model of ovarian cancer cachexia
- The 24-Hour Time Course of Integrated Molecular Responses to Resistance Exercise in Human Skeletal Muscle Implicates <i>MYC</i> as a Hypertrophic Regulator That is Sufficient for Growth
Showing 5 of 11 shared publications
J. William Deaver
University of Arkansas at Fayetteville (US)
9 shared publications
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration
Showing 5 of 9 shared publications
Landen W. Saling
University of Arkansas at Fayetteville
8 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- Growth Differentiation Factor 5 Is A Paracrine Regulator In Sarcopenic Obesity
Showing 5 of 8 shared publications
Stavroula Tsitkanou
University of Arkansas at Fayetteville
7 shared publications
In database
- Exercise Counteracts the Deleterious Effects of Cancer Cachexia
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- Biological sex divergence in transcriptomic profiles during the onset of hindlimb unloading-induced atrophy
- Myocellular adaptations to short‐term weighted wheel‐running exercise are largely conserved during C26‐tumour induction in male and female mice
Showing 5 of 7 shared publications
Michael P. Wiggs
Baylor University (US)
6 shared publications
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Males, But Not Females, Demonstrate Mitochondrial Dysfunction In The C26 Model Of Cancer Cachexia
Showing 5 of 6 shared publications
Luca J. Delfinis
York University (CA)
6 shared publications
- Muscle weakness and mitochondrial stress occur before severe metastasis in a novel mouse model of ovarian cancer cachexia
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- Muscle weakness and mitochondrial stress occur before metastasis in a novel mouse model of ovarian cancer cachexia
- Mitochondrial-targeted plastoquinone therapy prevents early onset muscle weakness that occurs before atrophy during ovarian cancer
- Mitochondrial-targeted plastoquinone therapy ameliorates early onset muscle weakness that precedes ovarian cancer cachexia in mice
Showing 5 of 6 shared publications
Wesley S. Haynie
University of Arkansas at Fayetteville
5 shared publications
In database
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The effect of autologous repair and voluntary wheel running on force recovery in a rat model of volumetric muscle loss
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- Leucine Supplementation Exacerbates Morbidity in Male but Not Female Mice with Colorectal Cancer-Induced Cachexia
David E. Lee
University of Arkansas at Fayetteville (US)
5 shared publications
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- MicroRNA control of the myogenic cell transcriptome and proteome: the role of miR-16
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