Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-15
J
Jacob L Edmondson
Researcher
Faculty Researcher
3 h-index
14 pubs
133 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Jacob L. Edmondson's research focuses on the molecular mechanisms underlying cancer progression and the development of anti-tumor immunity. His work investigates the role of specific proteins, such as NEK2 and EZH2, in tumorigenesis and how their modulation can impact cancer development. Edmondson also studies the activation of cellular pathways, like ATF6, and their influence on the immune response to cancer, particularly in the context of melanoma.
Further research areas include the dynamics of proteome turnover in T cell exhaustion, aiming to identify factors that enhance T cell persistence. He also examines the impact of metabolic stress on cancer cells and the immune machinery. Edmondson has published 14 works, with a total of 130 citations and an h-index of 3. He has collaborated with several researchers at the University of Arkansas for Medical Sciences, including Brian Koss, Daniel Fil, Megan R. Reed, and Billie Heflin.
Metrics
- h-index: 3
- Publications: 14
- Citations: 133
Selected Publications
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Abstract 6545: Characterizing ATF6 activation-driven mechanisms improving ICB efficacy (2026)
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691 ATF6 activation promotes ICB response in melanoma (2025)
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762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments (2025)
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277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion (2025)
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Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion (2025)
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EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma (2025)
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1132 Enhancing melanoma therapy efficacy by protecting EZH2 activity in T cells (2024)
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538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response (2024)
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319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion (2024)
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932 Defining the role for PCK2 in T-cell metabolic plasticity (2024)
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Role of NEK2 in tumorigenesis and tumor progression (2024)
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Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity (2024)
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536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma (2023)
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Abstract LB041: EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma (2023)
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Proteogenomic analysis of melanoma brain metastases from distinct anatomical sites identifies pathways of metastatic progression (2020)
Collaboration Network
Top Collaborators
Brian Koss
University of Arkansas for Medical Sciences
13 shared publications
In database
- Role of NEK2 in tumorigenesis and tumor progression
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract LB041: EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
- Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity
Showing 5 of 13 shared publications
Daniel Fil
University of Arkansas for Medical Sciences
10 shared publications
In database
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
- Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
Showing 5 of 10 shared publications
Alan J. Tackett
University of Arkansas for Medical Sciences
9 shared publications
In database
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract LB041: EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
- Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity
- 319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion
Showing 5 of 9 shared publications
Megan R. Reed
University of Arkansas for Medical Sciences
7 shared publications
In database
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract LB041: EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
- Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
Showing 5 of 7 shared publications
Billie Heflin
University of Arkansas for Medical Sciences
7 shared publications
In database
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract LB041: EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
- Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
Showing 5 of 7 shared publications
Sydnye L. Shuttleworth
University of Arkansas for Medical Sciences
6 shared publications
In database
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion
- Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion
- 277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion
- 762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments
Showing 5 of 6 shared publications
Lora J. Rogers
University of Arkansas for Medical Sciences
5 shared publications
In database
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion
- Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion
- 277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion
- 762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments
Jessica L Kelliher
University of Arkansas for Medical Sciences
5 shared publications
In database
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion
- Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion
- 277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion
- 762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments
Katherine Wallis
University of Arkansas for Medical Sciences
4 shared publications
In database
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
- 762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments
- 691 ATF6 activation promotes ICB response in melanoma
Michael Bauer
University of Arkansas for Medical Sciences
4 shared publications
In database
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion
- 277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion
Aaron J. Storey
Arkana Laboratories
3 shared publications
In database
- 319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion
- Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion
- 277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion
Dennis Province
University of Arkansas for Medical Sciences
3 shared publications
In database
- 319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion
- Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion
- 277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion
Nathan L. Avaritt
University of Arkansas for Medical Sciences
3 shared publications
In database
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
- 691 ATF6 activation promotes ICB response in melanoma
Lauren C. Morehead
University of Arkansas for Medical Sciences
2 shared publications
In database
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract LB041: EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma
Rick D. Edmondson
University of Arkansas for Medical Sciences
2 shared publications
In database
- 319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion
- 277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion
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