Eric U. Yee

High Impact

Associate Professor

UAMS

Also affiliated: Beth Israel Deaconess Medical Center (2012–2023); Berkeley College (1990); Harvard University (2012–2017); Hadassah Medical Center (2013–2014); University of Oklahoma Medical Center (2017); Stony Brook School (2020–2021); Statistical Research (United States) (2016); University of Oklahoma Health Sciences Center (2017–2023); Stony Brook University (2020–2021); University of Colorado Denver (2010)

Faculty Researcher

Pathology, College of Medicine

23 h-index 94 pubs 1,595 cited

Research Areas

Biomedical Subjects

Links

ORCID Research Group UAMS TRI Profile

OverviewAI-generated summary

Eric U. Yee's research focuses on understanding and modeling disease processes, particularly in the liver, and investigating the effects of various substances on biological systems. His work has explored the metabolic pathways critical for liver function and antioxidant capacity, as demonstrated in studies on pyruvate and alanine metabolism and their role in resistance to oxidative insult. He has also investigated the mechanisms behind liver injury, including the role of exogenous phosphatidic acid in mitigating acetaminophen-induced liver damage and the contribution of adenosine deaminase 2 to liver fibrosis in nonalcoholic fatty liver disease.

Yee's research extends to the use of animal models and in vitro systems to study toxicology and pharmacology. This includes studies on how certain drugs, such as budesonide, can exacerbate conditions like clostridioides difficile colitis in mice, and the effects of radiation on drug pharmacokinetics in rats. Furthermore, his group is developing and utilizing advanced techniques, such as human quad liver-on-chip systems, to bridge the gap between animal and human responses in toxicological and pharmacological assessments, and exploring machine learning for predicting pathologist attention in whole slide imaging for cancer evaluation.

His work is supported by a network of collaborators, including Felicia D. Allard from the University of Arkansas at Fayetteville, and Mitchell R. McGill, Stefanie Kennon‐McGill, and Steven R. Post from the University of Arkansas for Medical Sciences. With a career marked by 94 publications and over 1,574 citations, and an h-index of 22, Yee is recognized as a highly cited researcher.

Metrics

h-index: 23
Publications: 94
Citations: 1,595

Selected Publications

Repurposing Monensin and Its Derivatives as Immune-Modulatory Candidates for Metastatic Breast Cancer (Abstract ID: 231537) (2026)

Journal of Pharmacology and Experimental Therapeutics DOI OpenAlex
Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models (2025)

ACS Pharmacology & Translational Science 1 citation DOI OpenAlex
Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model (2025)

bioRxiv (Cold Spring Harbor Laboratory) DOI OpenAlex
Monensin and Its Analogs Offer a Multi-Targeted Approach to Enhancing Metastatic Breast Cancer Immunogenicity and Cell Death (Abstract ID: 163059) (2025)

Journal of Pharmacology and Experimental Therapeutics DOI OpenAlex
474 Repositioning monensin: Enhancing anti-cancer activity and immune modulation in breast cancer cells (2025)

Journal of Clinical and Translational Science DOI OpenAlex
Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract (2024)

Drug and Chemical Toxicology 3 citations DOI OpenAlex
Inter-strain variability in responses to a single administration of the cannabidiol-rich cannabis extract in mice (2024)

Food and Chemical Toxicology 2 citations DOI OpenAlex
Targeting Tri-Methyl-Histone H3 (Lys27) in Rectal Cancer: A Novel Strategy to Enhance Radiosensitivity and Predict Response to Neoadjuvant Therapy (2023)

International Journal of Radiation Oncology*Biology*Physics DOI OpenAlex
Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult (2023)

Molecular Metabolism 28 citations DOI OpenAlex
Budesonide, an anti-inflammatory drug, exacerbate clostridioides difficile colitis in mice (2023)

Biomedicine & Pharmacotherapy 3 citations DOI OpenAlex
S2431 A Rare Case of Esophageal Kaposi Sarcoma Causing Dysphagia (2022)

The American Journal of Gastroenterology DOI OpenAlex
Predicting the Visual Attention of Pathologists Evaluating Whole Slide Images of Cancer (2022)

Lecture notes in computer science 4 citations DOI OpenAlex
Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult in mice (2022)

bioRxiv (Cold Spring Harbor Laboratory) 2 citations DOI OpenAlex
Radiation Effects on Methamphetamine Pharmacokinetics and Pharmacodynamics in Rats (2022)

European Journal of Drug Metabolism and Pharmacokinetics 3 citations DOI OpenAlex
Adenosine deaminase 2 produced by infiltrative monocytes promotes liver fibrosis in nonalcoholic fatty liver disease (2021)

Cell Reports 17 citations DOI OpenAlex