Katherine Wallis
Research Assistant
Also affiliated: University of California, Irvine (1980)
Graduate Student Researcher
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Katherine Wallis's research focuses on the intersection of diet, metabolism, and cancer treatment, particularly investigating the role of nutrient restriction in enhancing responses to immune checkpoint inhibitors. Her work has explored the impact of methionine depletion on tumor-bearing mice, demonstrating increased sensitivity to immunotherapies in colorectal cancer models. Wallis has also investigated the effects of caloric restriction mimetics and compounds like resveratrol on melanoma treatment, examining their influence on antigen presentation and immune responses. Her experimental approaches include cell culture, in vitro assays, and studies in animal models, involving techniques such as western blots, Seahorse assays, and tissue collection. Wallis has also processed clinical patient samples for research purposes and optimized tumor models. She has a publication record that includes studies on cell death mechanisms, immune checkpoint inhibitors, and melanoma treatment strategies.
Metrics
- h-index: 5
- Publications: 20
- Citations: 160
Selected Publications
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Metabolic phenotypes of doxorubicin-induced cardiotoxicity among patients with breast cancer (2026)
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Abstract 6545: Characterizing ATF6 activation-driven mechanisms improving ICB efficacy (2026)
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685 EZH2 inhibition impairs CD8+ CAR-T cell persistence (2025)
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691 ATF6 activation promotes ICB response in melanoma (2025)
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762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments (2025)
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236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response (2025)
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538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response (2024)
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929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells (2024)
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932 Defining the role for PCK2 in T-cell metabolic plasticity (2024)
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Abstract 3625: Metabolic phenotypes of doxorubicin-induced cardiotoxicity in breast cancer patients (2024)
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Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma (2023)
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Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model (2023)
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Increased response to immune checkpoint inhibitors with dietary methionine restriction (2023)
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Abstract P3-08-08: Establishment of a Breast Cancer Rat Model of Chemotherapy-Induced Cardiotoxicity (2023)
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Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction (2023)
Collaboration Network
Top Collaborators
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- Abstract 1577: Caloric restriction mimetics as adjuvant to immune checkpoint inhibitors for treatment of melanoma
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
Showing 5 of 9 shared publications
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
- 236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response
Showing 5 of 8 shared publications
- Differences in cell death in methionine versus cysteine depletion
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction
- Increased response to immune checkpoint inhibitors with dietary methionine restriction
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
Showing 5 of 7 shared publications
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction
- Increased response to immune checkpoint inhibitors with dietary methionine restriction
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- Abstract 1577: Caloric restriction mimetics as adjuvant to immune checkpoint inhibitors for treatment of melanoma
Showing 5 of 7 shared publications
- Differences in cell death in methionine versus cysteine depletion
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction
- Increased response to immune checkpoint inhibitors with dietary methionine restriction
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
Showing 5 of 6 shared publications
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells
- 236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response
- 762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments
- 691 ATF6 activation promotes ICB response in melanoma
Showing 5 of 6 shared publications
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction
- Increased response to immune checkpoint inhibitors with dietary methionine restriction
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
- 691 ATF6 activation promotes ICB response in melanoma
- 685 EZH2 inhibition impairs CD8+ CAR-T cell persistence
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
- 762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments
- 691 ATF6 activation promotes ICB response in melanoma
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response
- 762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments
- 685 EZH2 inhibition impairs CD8+ CAR-T cell persistence
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells
- 236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response
- 762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction
- Increased response to immune checkpoint inhibitors with dietary methionine restriction
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
- 691 ATF6 activation promotes ICB response in melanoma
- 685 EZH2 inhibition impairs CD8+ CAR-T cell persistence
- 236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response
- 762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments
- 685 EZH2 inhibition impairs CD8+ CAR-T cell persistence
- Abstract P3-08-08: Establishment of a Breast Cancer Rat Model of Chemotherapy-Induced Cardiotoxicity
- Abstract 3625: Metabolic phenotypes of doxorubicin-induced cardiotoxicity in breast cancer patients
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