Match tier
Confirmed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
N
Nükhet Aykin‐Burns
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Associate Professor
Also affiliated: University of Iowa (2004–2013); Arkansas Children's Hospital (2017); Missouri University of Science and Technology (2002–2006); University of Arkansas Medical Center (2013–2021); Central Arkansas Veterans Healthcare System (2014); ORCID (2021); University of Iowa Health Care (2010); University of Iowa Holden Comprehensive Cancer Center (2004–2011); University of Pennsylvania (2021)
36 h-index
115 pubs
7,642 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Nükhet Aykin‐Burns' research focuses on mitochondrial function and cellular stress responses, particularly in the context of cancer and aging. Her work investigates the roles of key enzymes and proteins, such as Sirtuin 3 (SIRT3), in maintaining mitochondrial integrity and cellular metabolism under various stress conditions, including glucose deprivation. Aykin‐Burns has explored how reactive oxygen species, including superoxide and hydrogen peroxide, mediate differential susceptibility between cancer cells and normal cells, and how mutations in metabolic enzymes like succinate dehydrogenase can lead to increased oxidative stress and genomic instability.
Her research also extends to the clearance of senescent cells and its potential to rejuvenate aged stem cells, as demonstrated in studies involving mice. Aykin‐Burns has examined the interaction of SIRT3 with transcription factors like FOXO3a, influencing gene expression related to cellular stress and longevity. Her publications cover a range of topics from the biochemical pathways of enzyme activation to the broader implications of oxidative stress in disease models. She has a significant publication record, with over 100 publications and more than 7,000 citations, and is recognized as a highly cited researcher. Aykin‐Burns leads a research group and collaborates with several colleagues at the University of Arkansas for Medical Sciences.
Metrics
- h-index: 36
- Publications: 115
- Citations: 7,642
Positions
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Associate Professor 2011–presentUniversity of Arkansas for Medical Sciences Department of Pharmaceutical Sciences ORCID
Selected Publications
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Assessing Pain Linked to High Metabolic and Glycolytic Shift in Neurofibromatosis Type 1 (NF1) Patients by Using a Bioenergetic Biomarker: A Pilot Study (2026)
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Abstract LB219: Proteomic signatures of doxorubicin-induced lymphatic dysfunction in tumor-bearing rats (2026)
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SIRT3–IDH2 axis is a target of dietary fructose: implication of IDH2 as a key player in dietary carcinogen toxicity in mice colon (2025)
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Sirtuin-3 promotes osteoclast maturation and bone loss by regulating mitochondrial ROS production during ionizing radiation exposure (2025)
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Enhancing Rectal Cancer Radiosensitivity and Gut Protection through Methionine Restriction (2025)
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SIRT3-IDH2 axis is a target of dietary fructose: implication of IDH2 as a key player in dietary carcinogen toxicity in mice colon (2025)
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Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects (2023)
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The Role of Cytochrome P450 3A4-Mediated Metabolism in Sorafenib and Lapatinib Hepatotoxicity (2023)
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466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator (2023)
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Abstract 2839: Methionine restriction radiosensitizes KRAS mutant rectal cancer (2023)
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Effect of Sirt3 on hippocampal MnSOD activity, mitochondrial function, physiology, and cognition in an aged murine model (2023)
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Effect of Sirt3 on Hippocampal MnSOD Activity, Mitochondrial Function, Physiology, And Cognition in an Aged Murine Model (2022)
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Effect of Sirt3 on Hippocampal MnSOD Activity, Mitochondrial Function, Physiology, and Cognition in an Aged Murine Model (2022)
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Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice (2022)
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Chemotherapy induced oxidative stress in the ovary: drug-dependent mechanisms and potential interventions (2022)
Collaboration Network
Top Collaborators
Kimberly J. Krager
University of Arkansas for Medical Sciences
44 shared publications
In database
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
- Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors
- Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Radiation-Induced Alterations in Mitochondria of the Rat Heart
Showing 5 of 44 shared publications
Martin Hauer‐Jensen
University of Arkansas for Medical Sciences
14 shared publications
In database
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
- Radiation-Induced Alterations in Mitochondria of the Rat Heart
- Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction
- In VitroToxicity and Epigenotoxicity of Different Types of Ambient Particulate Matter
- A Tocotrienol-Enriched Formulation Protects against Radiation-Induced Changes in Cardiac Mitochondria without Modifying Late Cardiac Function or Structure
Showing 5 of 14 shared publications
Francesca V. LoBianco
University of Arkansas for Medical Sciences
11 shared publications
In database
- Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells
- The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury
- The Role of Cytochrome P450 3A4-Mediated Metabolism in Sorafenib and Lapatinib Hepatotoxicity
- Effect of Sirt3 on hippocampal MnSOD activity, mitochondrial function, physiology, and cognition in an aged murine model
- Assessment of Cellular Oxidation using a Subcellular Compartment-Specific Redox-Sensitive Green Fluorescent Protein
Showing 5 of 11 shared publications
Rupak Pathak
University of Arkansas for Medical Sciences
8 shared publications
In database
- In VitroToxicity and Epigenotoxicity of Different Types of Ambient Particulate Matter
- Liver Metabolomics Reveals Increased Oxidative Stress and Fibrogenic Potential in Gfrp Transgenic Mice in Response to Ionizing Radiation
- Characterization of Transgenic Gfrp Knock-In Mice: Implications for Tetrahydrobiopterin in Modulation of Normal Tissue Radiation Responses
- Utilization of Vitamin E Analogs to Protect Normal Tissues While Enhancing Antitumor Effects
- Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
Showing 5 of 8 shared publications
Antiño R. Allen
University of Arkansas for Medical Sciences
7 shared publications
In database
- Chemotherapy induced oxidative stress in the ovary: drug-dependent mechanisms and potential interventions
- Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells
- Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice
- Effect of Sirt3 on hippocampal MnSOD activity, mitochondrial function, physiology, and cognition in an aged murine model
- The sex-dependent impact of SIRT3 on cognition
Showing 5 of 7 shared publications
Ha‐Neui Kim
University of Arkansas for Medical Sciences
7 shared publications
In database
- Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors
- Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
- Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
- Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice
- Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice
Showing 5 of 7 shared publications
Marjan Boerma
University of Arkansas for Medical Sciences
6 shared publications
In database
- Radiation-Induced Alterations in Mitochondria of the Rat Heart
- A Tocotrienol-Enriched Formulation Protects against Radiation-Induced Changes in Cardiac Mitochondria without Modifying Late Cardiac Function or Structure
- Characterization of Transgenic Gfrp Knock-In Mice: Implications for Tetrahydrobiopterin in Modulation of Normal Tissue Radiation Responses
- Utilization of Vitamin E Analogs to Protect Normal Tissues While Enhancing Antitumor Effects
- Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin
Showing 5 of 6 shared publications
César M. Compadre
University of Arkansas for Medical Sciences
5 shared publications
In database
- Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans)
- Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells
- Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
- Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity
- 466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator
Haibo Zhao
Southern California Institute for Research and Education (US)
5 shared publications
- Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Author response: Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- The Murine Osteoclasts Lacking Transferrin Receptor 1 have Altered Mitochondrial Metabolism, Cytoskeletal Organization and Increased Trabecular Bone Mass
Samuel G. Mackintosh
University of Arkansas for Medical Sciences
5 shared publications
In database
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Author response: Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- Abstract 1029: Epigenetic control of tumor-infiltrating lymphocyte metabolic-exhaustion
Kimberly Richardson
University of Arkansas for Medical Sciences (US)
5 shared publications
- Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency
- Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
- Simulated Galactic Cosmic Rays Modify Mitochondrial Metabolism in Osteoclasts, Increase Osteoclastogenesis and Cause Trabecular Bone Loss in Mice
- Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice
- Sirtuin-3 promotes osteoclast maturation and bone loss by regulating mitochondrial ROS production during ionizing radiation exposure
Philip J. Breen
University of Arkansas for Medical Sciences
4 shared publications
In database
- Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans)
- Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
- Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity
- 466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator
Snehalata A. Pawar
University of Arkansas for Medical Sciences (US)
4 shared publications
- Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction
- Characterization of Transgenic Gfrp Knock-In Mice: Implications for Tetrahydrobiopterin in Modulation of Normal Tissue Radiation Responses
- C/EBPδ Modulates Reactive Oxygen Species to Protect againstIR-Induced Cell Death
- C/EBPS Regulates Oxidative Stress and Mitochondrial Dysfunction to Promote Post-Radiation Survival
Qiang Fu
University of Arkansas for Medical Sciences
4 shared publications
In database
- Characterization of Transgenic Gfrp Knock-In Mice: Implications for Tetrahydrobiopterin in Modulation of Normal Tissue Radiation Responses
- Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice
- Sirtuin-3 promotes osteoclast maturation and bone loss by regulating mitochondrial ROS production during ionizing radiation exposure
- The Role of Tetrahydrobiopterin (BH4) Bioavailability in Radiation-Induced Skin Injury
Sarita Garg
University of Arkansas for Medical Sciences
4 shared publications
In database
- Characterization of Transgenic Gfrp Knock-In Mice: Implications for Tetrahydrobiopterin in Modulation of Normal Tissue Radiation Responses
- Recombinant Thrombomodulin (Solulin) Ameliorates Early Intestinal Radiation Toxicity in a Preclinical Rat Model
- Abstract 2839: Methionine restriction radiosensitizes KRAS mutant rectal cancer
- Enhancing Rectal Cancer Radiosensitivity and Gut Protection through Methionine Restriction
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