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Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
I
Igor Koturbash
High Impact
Professor
Also affiliated: University of Lethbridge (2005–2016); United States Food and Drug Administration (2010–2015); United States Pharmacopeial Convention (2024)
Environmental Health Sciences, College of Public Health
45 h-index
156 pubs
6,316 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Igor Koturbash studies the effects of environmental exposures on biological systems, with a particular focus on radiation and air pollution. His research investigates mechanisms of DNA damage, epigenetic alterations, and the development of cancer following exposure to ionizing radiation and particulate matter. He has examined these effects in both animal models and human tissue, exploring how exposures can lead to DNA double-strand breaks, global DNA hypermethylation, and persistent bystander effects in distant tissues.
Koturbash's work has been supported by grants and has resulted in over 150 publications, earning him recognition as a highly cited researcher. His collaborations include extensive work with colleagues at the University of Arkansas for Medical Sciences, such as Marjan Boerma, Laura Ewing, Charles M. Skinner, and Rupak Pathak. His research group actively investigates the long-term health consequences of environmental exposures, contributing to the understanding of disease mechanisms at the molecular and cellular levels.
Metrics
- h-index: 45
- Publications: 156
- Citations: 6,316
Positions
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Professor and Department Chair 2023–presentUniversity of Arkansas for Medical Sciences Environmental Health Sciences ORCID
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Dietary Supplements Admission Evaluation and Labeling Expert Committee Member 2020–presentUnited States Pharmacopeia ORCID
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Founder and Co-Director of Dietary Supplements Research 2018–presentUniversity of Arkansas for Medical Sciences ORCID
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Professor publications 2013–2026University of Arkansas for Medical Sciences Environmental Health Sciences, College of Public Health Institutional directory
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Associate Professor 2017–2023University of Arkansas for Medical Sciences Environmental Health Sciences ORCID
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Assistant Professor 2012–2017University of Arkansas for Medical Sciences Environmental Health and Occupational Health Sciences ORCID
Selected Publications
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(6S)-5-Methyltetrahydrofolate Dicholine Salt Modulates Methyl-Donor Metabolites and Repetitive-Element DNA Methylation in HepaRG Cells (2026)
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Co-occurring substance use disorders and the compounding effect of kratom on serious mental illness, US, 2021–2023 (2026)
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From kratom to 7-hydroxymitragynine: evolution of a natural remedy into a public-health threat (2025)
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Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice (2025)
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A Systematic and Ethnobotanical Review of Ashwagandha's ( Withania Somnifera ) Teratogenic and Abortifacient Potentials (2025)
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Sex-specific immune alterations in mice following long-term simulated microgravity and chronic irradiation (2025)
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Long-term effects of combined exposures to simulated microgravity and galactic cosmic radiation on the mouse lung: sex-specific epigenetic reprogramming (2025)
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A Combined Approach for Rapid Dereplication of Herb–Drug Interaction Causative Agents in Botanical Extracts─A Molecular Networking Strategy To Identify Potential Pregnane X Receptor (PXR) Modulators in Yohimbe (2024)
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Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading (2024)
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First-year evaluation of a campus-wide, cross-disciplinary scholarly writing development program supported by a center for biomedical research excellence (COBRE) (2024)
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DSHEA 1994 – Celebrating 30 Years of Dietary Supplement Regulation in the United States (2024)
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Developing a Screening Strategy to Identify Hepatotoxicity and Drug Interaction Potential of Botanicals (2024)
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Botanical-induced toxicity: Liver injury and botanical-drug interactions. A report on a society of Toxicology Annual Meeting symposium (2024)
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Phenibut: A drug with one too many “buts” (2024)
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Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract (2024)
Grants & Funding
As listed on this researcher's institutional profile.
- Analysis of hepatotoxicity of the OxyELITE Pro dietary supplement in a mouse model US Department of Justice Principal Investigator
- The Diversity Outbred: A Tool to Improve Preclinical Safety Testing and Pharmacog U.S. Food and Drug Administration Principal Investigator
- Integration of in-silico and in-vivo Models for Determining Preclinical Indicators and/or Integrated Biomarkers of Radiation-Induced Vascular Dysfunction National Aeronautics & Space Administration via Louisiana State University Principal Investigator
- Team Leader for the Radiation Effects Team National Space Biomedical Research Institute via Baylor College of Medicine Co-Investigator
- Center for Studies of Host Response to Cancer Therapy NIH Co-Investigator
- Arkansas Center for Health Disparities (ARCHD): An NIMHD COE NIH Co-Investigator
- Effects of wood burning-associated smoke on satellite DNA NIH/Nat. Inst. for Occupational Safety & Health via University of Alabama at Birmingham Principal Investigator
- In vitro screening of a unique botanical extract collection for herb-drug interaction (HDI) potential NIH/National Center for Complementary and Integrative Health via University of Mississippi Principal Investigator
Collaboration Network
Top Collaborators
Isabelle R. Miousse
University of Arkansas for Medical Sciences
38 shared publications
In database
- Pediatric Exposures to Ionizing Radiation: Carcinogenic Considerations
- Effects of ionizing radiation on DNA methylation: from experimental biology to clinical applications
- Response of transposable elements to environmental stressors
- Short-term exposure to engineered nanomaterials affects cellular epigenome
- In vivoepigenetic effects induced by engineered nanomaterials: A case study of copper oxide and laser printer-emitted engineered nanoparticles
Showing 5 of 38 shared publications
Martin Hauer‐Jensen
University of Arkansas for Medical Sciences
24 shared publications
In database
- Effects of ionizing radiation on the heart
- Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome
- Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
- Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart
- Densely ionizing radiation affects DNA methylation of selective LINE-1 elements
Showing 5 of 24 shared publications
Marjan Boerma
University of Arkansas for Medical Sciences
21 shared publications
In database
- Effects of ionizing radiation on the heart
- Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome
- Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart
- Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice
- A priming dose of protons alters the early cardiac cellular and molecular response to 56Fe irradiation
Showing 5 of 21 shared publications
Charles M. Skinner
University of Arkansas for Medical Sciences
21 shared publications
In database
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
- Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart
- Densely ionizing radiation affects DNA methylation of selective LINE-1 elements
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
Showing 5 of 21 shared publications
Rupak Pathak
University of Arkansas for Medical Sciences
17 shared publications
In database
- Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
- Densely ionizing radiation affects DNA methylation of selective LINE-1 elements
- Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation
- The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage
- Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome
Showing 5 of 17 shared publications
Laura Ewing
University of Arkansas for Medical Sciences
17 shared publications
In database
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- MicroRNAs as biomarkers for liver injury: Current knowledge, challenges and future prospects
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Potential Probiotic or Trigger of Gut Inflammation – The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract
- Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome
Showing 5 of 17 shared publications
Bill J. Gurley
University of Mississippi
15 shared publications
In database
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- MicroRNAs as biomarkers for liver injury: Current knowledge, challenges and future prospects
- Hepatotoxicity due to herbal dietary supplements: Past, present and the future
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Cannabidiol (CBD) in Dietary Supplements: Perspectives on Science, Safety, and Potential Regulatory Approaches
Showing 5 of 15 shared publications
Igor P. Pogribny
National Center for Toxicological Research
12 shared publications
In database
- Role of epigenetic events in chemical carcinogenesis—a justification for incorporating epigenetic evaluations in cancer risk assessment
- Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay
- Epigenetic Mechanisms of Mouse Interstrain Variability in Genotoxicity of the Environmental Toxicant 1,3-Butadiene
- Interstrain differences in the severity of liver injury induced by a choline‐ and folate‐deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism
- Epigenetic Alterations in Liver of C57BL/6J Mice after Short-Term Inhalational Exposure to 1,3-Butadiene
Showing 5 of 12 shared publications
Vijayalakshmi Sridharan
University of Arkansas for Medical Sciences
12 shared publications
In database
- Effects of ionizing radiation on the heart
- Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome
- Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart
- Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice
- A priming dose of protons alters the early cardiac cellular and molecular response to 56Fe irradiation
Showing 5 of 12 shared publications
Frederick A. Beland
National Center for Toxicological Research
11 shared publications
In database
- Role of epigenetic events in chemical carcinogenesis—a justification for incorporating epigenetic evaluations in cancer risk assessment
- Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay
- Epigenetic Mechanisms of Mouse Interstrain Variability in Genotoxicity of the Environmental Toxicant 1,3-Butadiene
- Interstrain differences in the severity of liver injury induced by a choline‐ and folate‐deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism
- Epigenetic Alterations in Liver of C57BL/6J Mice after Short-Term Inhalational Exposure to 1,3-Butadiene
Showing 5 of 11 shared publications
Stepan Melnyk
University of Arkansas for Medical Sciences
11 shared publications
In database
- Short-term exposure to engineered nanomaterials affects cellular epigenome
- Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
- Interstrain differences in the severity of liver injury induced by a choline‐ and folate‐deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism
- Role of epigenetic and miR‐22 and miR‐29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2‐acetylaminofluorene
- One-carbon metabolism and ionizing radiation: a multifaceted interaction
Showing 5 of 11 shared publications
Kristy Kutanzi
University of Arkansas for Medical Sciences
11 shared publications
In database
- Pediatric Exposures to Ionizing Radiation: Carcinogenic Considerations
- Effects of ionizing radiation on DNA methylation: from experimental biology to clinical applications
- Interstrain differences in the severity of liver injury induced by a choline‐ and folate‐deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism
- Densely ionizing radiation affects DNA methylation of selective LINE-1 elements
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
Showing 5 of 11 shared publications
Gregory A. Nelson
Loma Linda University (US)
9 shared publications
- Effects of ionizing radiation on the heart
- Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome
- Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart
- Densely ionizing radiation affects DNA methylation of selective LINE-1 elements
- Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice
Showing 5 of 9 shared publications
Mahmoud A. ElSohly
University of Mississippi (US)
9 shared publications
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Cannabidiol (CBD) in Dietary Supplements: Perspectives on Science, Safety, and Potential Regulatory Approaches
- Potential Probiotic or Trigger of Gut Inflammation – The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract
- Safety assessment of the dietary supplement OxyELITE™ Pro (New Formula) in inbred and outbred mouse strains
Showing 5 of 9 shared publications
Mitchell R. McGill
University of Arkansas for Medical Sciences
9 shared publications
In database
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- Hepatotoxicity due to herbal dietary supplements: Past, present and the future
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F1 Mice
- Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration
Showing 5 of 9 shared publications
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